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T-cell depletion for bone marrow transplantation: Effects on graft rejection, graft-versus-host disease, graft-versus-leukemia, and survival

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Bone Marrow Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 50))

Abstract

Graft-versus-host disease (GVHD) remains the major problem to be overcome in allogeneic bone marrow transplantation [1–3]. Despite posttransplant immunosuppressive therapy with cyclosporine or methotrexate, moderate to severe acute GVHD develops in approximately 45% of transplant recipients with an HLA-identical sibling donor [4] and in >75% of patients from HLA-nonidentical relatives [5]. Recently, bone marrow transplants have been performed from unrelated HLA-identical or partially matched related donors [6–10]. Preliminary results indicate that even with phenotypically identical unrelated donor-recipient pairs and the use of combination posttransplant immunosuppressive therapy, the incidence of acute GVHD exceeds 75%.

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  1. Richard E. Champlin
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  1. MD Anderson Cancer Center, Houston, Texas, USA

    Richard Champlin M.D.

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© 1990 Kluwer Academic Publishers

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Champlin, R.E. (1990). T-cell depletion for bone marrow transplantation: Effects on graft rejection, graft-versus-host disease, graft-versus-leukemia, and survival. In: Champlin, R. (eds) Bone Marrow Transplantation. Cancer Treatment and Research, vol 50. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1493-6_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1493-6_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8803-9

  • Online ISBN: 978-1-4613-1493-6

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