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Recapitulation of immune ontogeny: A vital component for the success of bone marrow transplantation

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Bone Marrow Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 50))

Abstract

Human bone marrow transplantation (BMT) has become an important treatment for patients with aplastic anemia, hematologic malignancies, immunodeficiency disorders, and inborn errors of metabolism [1–4]. The preparative regimens are designed to eliminate the “last” malignant clone and to suppress the host immune system. Ablation of the host immune system leaves the recipient immunologically crippled and susceptible to infections up to 2 years after BMT, while the donor-derived immune system is developing [5–8]. Therefore, BMT offers unique models of immunodeficiency wherein immunity develops if the recipients do not succumb to graft-versus-host disease (GVHD), infections, or nonmarrow organ toxicity [9–13].

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  1. MD Anderson Cancer Center, Houston, Texas, USA

    Richard Champlin M.D.

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Lum, L.G. (1990). Recapitulation of immune ontogeny: A vital component for the success of bone marrow transplantation. In: Champlin, R. (eds) Bone Marrow Transplantation. Cancer Treatment and Research, vol 50. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1493-6_3

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