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Fine Needle Aspiration Biopsy in Clinical Renal Transplantation

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International Yearbook of Nephrology 1990

Part of the book series: International Yearbooks of Nephrology ((IYNE,volume 2))

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Abstract

Fine needle aspiration biopsy (FNAB) is a new technique which is being applied with increasing frequency as a clinical and investigational tool in kidney transplantation. FNAB is a means of sampling cells from the interstitium of the renal cortex in order to analyze the nature of inflammatory and toxic events occurring within the organ (1). The technique is a utilization of our increased understanding of the sequential intragraft events that occur in the rejecting allograft (2–5). FNAB owes its introduction into clinical transplantation to the work of Häyry and Von Willebrand (1, 3–6), who adapted the technique first described for renal transplants by Pasternak (7). Though it is clearly a valuable new adjunct in the diagnostic armamentarium of the transplant physician, its final place in transplant management is yet to be finally determined.

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References

  1. Häyry P, Von Willebrand E, Ahonen T, Lautenschlager I and Neskinen R: Aspiration cytology in organ transplantation. Transpl Rev, 1: 133–157, 1977.

    Article  Google Scholar 

  2. Strom TB, Tilney NL, Carpenter CB and Busch GJ: Identity and cytotoxic capacity of cells infiltrating renal allografts. New Engl J Med, 292: 1257–1263, 1975.

    Article  PubMed  CAS  Google Scholar 

  3. Von Willebrand E, Soots A and Häyry P: In situ effector mechanisms in rat kidney allograft rejection: I. Characterization of host cellular infiltrate in rejecting allograft parenchyma. Cell Immunol, 46: 309–326, 1979.

    Article  Google Scholar 

  4. Häyry P, Von Willebrand E and Soots A: In situ effector mechanisms in rat kidney allograft rejection: III. Kinetics of the inflammation response and generation of donor-directed killer cells. Scand J Immunol, 10: 95–108, 1979.

    Article  PubMed  Google Scholar 

  5. Von Willebrand E and Häyry P: Composition and in vitro cytotoxicity of cellular infiltrates in rejecting human allografts. Cell Immunol, 41: 358–372, 1978.

    Article  Google Scholar 

  6. Häyry P and Von Willebrand E: Transplant aspiration cytology. Transplantation, 38: 7–12, 1984.

    Article  PubMed  Google Scholar 

  7. Paternack A: Fine needle aspiration biopsy of human renal homografts. Lancet, ii: 82–84, 1968.

    Article  Google Scholar 

  8. Von Willebrand E: Fine needle aspiration cytology of human renal transplants. Clin Immunol Immunopathol, 17: 309–322, 1980.

    Article  Google Scholar 

  9. Häyry P and Von Willebrand E: Practical guidelines for fine needle aspiration biopsy of human renal allografts. Ann Clin Res, 13: 288–306, 1981.

    PubMed  Google Scholar 

  10. Häyry P and Von Willebrand E: Monitoring of human renal allograft rejection with fine needle aspiration cytology. Scand J Immunol 13: 87–97, 1981.

    Article  PubMed  Google Scholar 

  11. Belitsky P, Campbell J and Giopta R: Serial biopsy controlled evaluation of fine-needle aspiration in renal allograft rejection. Lab Invest, 53: 580–585, 1985.

    PubMed  CAS  Google Scholar 

  12. Von Willebrand E, Zola H and Häyry P: Thombocyte aggregation in renal allografts. Transplantation, 39: 258–262, 1985.

    Article  Google Scholar 

  13. Cooksey G, Reeve RS, Nicolopoulos N, Burden RP, Cotton RE and Blarney RW: Monitoring the response to treatment of renal allograft rejection with fine needle aspiration cytology. Trans Proc, 17: 2085–2086, 1985.

    Google Scholar 

  14. Tufveson G, Backman V, Claesson K, Frodin L, Stenquist B and Wahlberg J: Renal transplant cytology: impact of different immunosuppressive protocols and biopsy techniques. Trans Proc, 17: 2087–2088, 1985.

    Google Scholar 

  15. Häyry P and Von Willebrand E: Diagnostic evaluation of the in situ inflammatory response of renal allograft rejection. Proc EDTA, 17: 418–423, 1980.

    Google Scholar 

  16. Häyry P: Monitoring of renal allografts by transplant aspiration cytology. Triangle, 21: 111–120, 1982.

    PubMed  Google Scholar 

  17. Nguyen L, Hammer C, Dendorfer U, Castro L, Schleibner C and Land W: Changes in large granular lymphocyte size and number in kidney transplant patients during rejection and viral infection. Trans Proc, 17: 2110–2111, 1985.

    Google Scholar 

  18. Ouziala M, Santelli G, Charpentier B and Fries D: Diagnostic value of fine needle aspiration biopsy during viral infections in renal transplant recipients. Trans Proc, 17: 2098–2099, 1985.

    Google Scholar 

  19. Arndt R, Heinzer P, Huland H, Lohning T and Kramer-Hansen H: Identification of virus DNA in kidney transplants by fine-needle aspiration biopsy. Trans Proc, 20: 581–583, 1988.

    CAS  Google Scholar 

  20. Stadler J, Heidecke C-D, Plorack G and Holscher M: Postischemic injury and acute tubular necrosis: diagnostic and prognostic value of fine-needle aspirates. Trans Proc, 20:687–689, 1988.

    CAS  Google Scholar 

  21. Baumgartner D, Burger HR, Binswanger U and Largiader F: Routine fine needle aspiration biospy adds clinically relevant information for evaluation and treatment of renal transplant recipients with primary oliguria. Trans Proc, 17: 2080–2081, 1985.

    Google Scholar 

  22. Egidi F, Banfi G, Bogetic J, Passerini P and Ponticelli C: Correlation between fine needle aspiration biopsy and renal biopsy in renal transplantation. Trans Proc, 20: 592–594, 1988.

    Google Scholar 

  23. Yussim A, Shapira Z, Shmueli D, Heibronn YD, Kaufman L and Servaclio C: The impact of transplant aspiration cytology in management of cyclosporin-A treated renal transplant recipients. Trans Proc 19: 1658, 1987.

    CAS  Google Scholar 

  24. Von Willebrand E and Häyry P: Cyclosporin-A deposits in renal allografts. Lancet, ii: 189–192, 1983.

    Article  Google Scholar 

  25. Egidi F, Torantino A, DeVecchi A, Zubani R and Ponticelli C: Patterns of inflammation in fine needle aspiration biopsies in renal transplant patients treated with different immunosuppressive regimens. Trans Proc, 17: 2091–2092, 1985.

    Google Scholar 

  26. O’Brien JP, Horsburgh T, Veitch PS and Bell PRF: Experience with fine needle aspiration biopsies from renal transplant patients on different immunosuppressive regimens. Trans Proc, 17: 2089–2090, 1985.

    Google Scholar 

  27. Surackno S, Van Oers MHJ and Wilmink JM: Early diagnosis of bacterial infection of renal allografts by fine needle aspiration biopsy. Lancet, i: 686–687, 1986.

    Article  Google Scholar 

  28. Hernandez JA, Glennie J, Toto R, Sagalowsky A, Davidsen I and Helderman JH: A novel use of fine-needle aspiration biopsy: documentation of acute pyelonephritis of the transplanted kidney. Trans Proc, 20: 632–634, 1988.

    CAS  Google Scholar 

  29. Helderman JH, Hernandez J, Sagalowsky A, Davidson I, Glennie J, Womble D and Toto RD: Confirmation of the utility of fine needle aspiration biopsy of the renal allograft. Kidney Int, 34: 376–381, 1988.

    Article  PubMed  CAS  Google Scholar 

  30. Bishop GA, Hall BM, Waugh J, Phillips T, Horuath JS, Duggin GG, Johnson JR, Ross-Sheil AG and Tiller DJ: Diagnosis of renal allograft rejection by analysis of fine needle aspiration biospy specimens with immunostains and simply cytology. Lancet, ii: 645–649, 1986.

    Article  Google Scholar 

  31. Danovitch GM, Nast C, Rosenthal and Wilkinson A: Fine needle aspiration biopsy in the diagnosis renal transplant dysfunction. Am Soc Transpl Phys, 134: 65, 1988 (Abstract).

    Google Scholar 

  32. Koller C, Hammer C, Govew M, Land W, Hillerbrand D, Castro LA, Badier J and Weber B: Correlation between core biopsy and aspiration cytology. Trans Proc, 16: 1298–1300, 1984.

    CAS  Google Scholar 

  33. Whelchel JD, Delaney VB, O’Brien D, Ling B, Fekete P and Campbell WG: Efficacy and cost of the various tests used in the diagnosis of rejection in cadaveric renal transplant recipients. Kidney Int, 35: 526, 1989.

    Google Scholar 

  34. Boshkos C, Steinmuller DR, Nouick AC, Streem S, Cunningham PJ, Fishleder A and Dlugosa B: Correlation between fine needle aspiration biopsies with core biopsies after renal transplantation. Trans Proc, 20: 592–594, 1988.

    CAS  Google Scholar 

  35. Manalich R, LaGarde M, Wellar C and Jiminez P: Intrarenal inflammation during rejection crises in renal allografts: comparison between fine needle aspiration cytology and renal biopsy. Trans Proc, 20: 601–602, 1988.

    CAS  Google Scholar 

  36. Hammerer P, Arndt R, Krämer-Hansen H, Huland H and Khosterhalfen H: Consecutive selective aspiration cytology of renal cortex and renal medulla in kidney transplants. Trans Proc, 20: 577–578, 1988.

    CAS  Google Scholar 

  37. Yussim A, Kaufman L, Shmuely D and Shapira Z: Aspiration cytology in late cellular rejection. Trans Proc, 20: 621–622, 1988.

    CAS  Google Scholar 

  38. Häyry P, Von Willebrand E, Ahonen J, Eklund B, Calmela K, Hîckerstedt K, Peterson E and Koskinies S: Effects of cyclosporine, azathioprine, and steroids on the renal transplant, on the cytologic patterns of intragraft inflammation, and on the concomitant rejection associated changes in recipient blood. Trans Proc, 20: 153–162, 1988.

    Google Scholar 

  39. Taube D, Welsh K, Hobby P, Williams DG: Human renal allograft and peripheral blood T-lymphocyte subpopulations during the onset and treatment of rejection. Clin Nephrol, 22: 127–132, 1984.

    PubMed  CAS  Google Scholar 

  40. Bolton EM, Thompson JF, Wood RFM, Morris PJ: Immunoperoxidase staining of fine-needle aspiration biopsies and needle core biopsies from renal allografts. Transplantation, 36: 728–730, 1983.

    Article  PubMed  CAS  Google Scholar 

  41. Fuggle SV, McWinnie DL and Morris PJ: Precise specificity of induced tubular HLA-class II antigens in renal allografts. Transplantation, 44: 214–220, 1987.

    Article  PubMed  CAS  Google Scholar 

  42. Helderman JH, Hernandez J, Glennie J and Womble D: The interleukin-2 receptor detected by fine needle aspiration specimens. Trans Proc, 20: 675–676, 1988.

    CAS  Google Scholar 

  43. McKenna RM, Heiman D, Rush DN and Jeffery JR: Limiting dilution analysis of the frequency of functional T cells in human renal allograft fine needle aspirates. Trans Proc, 20: 207–208, 1988.

    CAS  Google Scholar 

  44. Goldman M, Vandervorst P, Abramowicz D, Vereerstraeten P, Kinnaert P, Schandene L, Dupont E, Wybran J, Toussaint C: Interleukin-2 release assay in limiting dilution microcultures: possible application to fine needle aspiration of kidney transplants. Trans Proc, 17: 2117–2118, 1985.

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, CA, 90024-1689, USA

    Gabriel M. Danovitch, Cynthia C. Nast & Alan Wilkinson

Authors
  1. Gabriel M. Danovitch
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  2. Cynthia C. Nast
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  3. Alan Wilkinson
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Editor information

Editors and Affiliations

  1. University of Naples, Naples, Italy

    Vittorio E. Andreucci

  2. Division of Nephrology, University of California, Los Angeles, California, USA

    Leon G. Fine

  3. Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota, USA

    Carl M. Kjellstrand

  4. Department of Medicine Kidney Center, Tokyo Women’s Medical College, Tokyo, Japan

    Nobuhiro Sugino

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© 1990 Kluwer Academic Publishers

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Danovitch, G.M., Nast, C.C., Wilkinson, A. (1990). Fine Needle Aspiration Biopsy in Clinical Renal Transplantation. In: Andreucci, V.E., Fine, L.G., Kjellstrand, C.M., Sugino, N. (eds) International Yearbook of Nephrology 1990. International Yearbooks of Nephrology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1491-2_14

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  • DOI: https://doi.org/10.1007/978-1-4613-1491-2_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8802-2

  • Online ISBN: 978-1-4613-1491-2

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