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Prospects for NMR Microscopy

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Modern Microscopies
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Abstract

Early interest in the medical applications of magnetic resonance goes back to the late 1950s, when—it was then electron spin resonance (ESR)—differences were found in the signals obtained from tumors and normal tissue due to different concentrations of free radicals in them.(1) Preliminary forays were made into ESR imaging, but the frequencies of electromagnetic radiation required led to too much body absorption and scatter. The prospects for nuclear magnetic resonance (NMR) in medical research were first discussed in 1972.(2)

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References

  1. J. R. Mallard and M. Kent, “Differences observed between electron spin resonance signals from surviving tumor tissues and from their corresponding normal tissues,” Nature 204, 1192 (1964).

    Article  PubMed  CAS  Google Scholar 

  2. R. Damadian, K. Zaner, D. Hor, R. Dimaio, L. Minkoff, and M. Goldsmith, “Nuclear magnetic resonance as a new tool in cancer research: Tumors by NMR,” Ann. N.Y. Acad. Sci. 222, 1048–1076 (1973).

    Article  PubMed  CAS  Google Scholar 

  3. P. Lauterbur, “Image formation by induced local interactions: Examples employing nuclear magnetic resonance,” Nature 242, 190–191 (1973).

    Article  CAS  Google Scholar 

  4. J. M. S. Hutchison, J. R. Mallard, and C. C. Goll, “In vivo imaging of body structures using proton resonance,” in: Proceedings of the 18th Ampere Congress (P. S. Allen, E. R. Andrew and C. A. Bates, eds.), University of Nottingham, pp. 283–284 (1974).

    Google Scholar 

  5. J. Mallard, J. M. S. Hutchison, W. A. Edelstein, C. R. Ling, M. A. Foster, and G. Johnson, “In vivo NMR imaging in medicine: The Aberdeen approach, both physical and biological,” Phil. Trans. Roy. Soc. Lond B289, 519–533 (1980).

    Article  CAS  Google Scholar 

  6. W. A. Edelstein, J. M. S. Hutchison, G. Johnson, and T. W. Redpath, “Spin-warp NMR imaging and applications to human whole-body imaging,” Phys. Med. Biol. 25, 751–756 (1980).

    Article  PubMed  CAS  Google Scholar 

  7. J. R. Mallard, Wellcome Foundation Lecture, 1984. “Nuclear magnetic resonance imaging in medicine: Medical and biological applications and problems,” Proc. Roy. Soc. Lond. B226, 391–419 (1984).

    Google Scholar 

  8. H. Deans, personal communication (1987).

    Google Scholar 

  9. F. W. Smith, “Magnetic resonance imaging of midline brain tumors using inversion-recovery sequences at 0.08 T (3.4 MHz),” Magn. Reson. Med. 5, 118 - 128 (1987).

    Google Scholar 

  10. D. H. Carr, J. Brown, G. M. Bydder, R. E. Steiner, H. J. Weinmann, U. Speck, A. S. Hall, and I. R. Young,“Gadolinium-DTPA as a contrast agent in MRI,” Am. J. Roentg. 143, 215–224 (1984).

    Google Scholar 

  11. R. Felix, “The potential role of contrast media in magnetic resonance imaging,” 3rd Congress. Eur. Soc. Magn. Res. in Med. Biol., University of Aberdeen, pp. 71–72 (1986). Published by European Society for Magnetic Resonance in Medicine and Biology, Geneva, Switzerland.

    Google Scholar 

  12. J. Sadler, personal communication (1987).

    Google Scholar 

  13. M. A. Foster, “Contrast manipulation,” in: NMR Proton Imaging Summer School Lecture Notes, University of Aberdeen (1987).

    Google Scholar 

  14. Medical Research Council Review of Clinical Evaluation of Magnetic Resonance Imaging (1987). Available from Medical Research Council, London.

    Google Scholar 

  15. F. W. Wehrli, J. R. McFall, D. Shutts, R. Breger, and R. T. Herfken, “Mechanisms of contrast in NMR imaging,” J. Comp. Assist. Tomog. 8, 369–380 (1984).

    Article  CAS  Google Scholar 

  16. M. A. Foster, “Tissue characterization by NMR,” in: Functional Studies Using NMR (V. R. McCready, M. Leach, and P. J. Ell, eds.), pp. 147–166, Springer-Verlag, London (1986).

    Google Scholar 

  17. Concerted Research Project of the European Economic Community. Reported in European Quarterly, Nos. 1–15, published by the European Economic Community and available from F. Podo, Instituto Superiore di Sanita, 0016, Rome, Italy.

    Google Scholar 

  18. M. A. Foster and J. R. Mallard, “Biological basis and clinical value of tissue characterization by NMR,” Proc. 9th Ann. Conf. of IEEE Engineering in Medicine and Biology, Boston, p. 1973 (1987).

    Google Scholar 

  19. R. M. Kroeker, E. R. McVeigh, P. Hardy, M. T. Bunskill, and R. M. Henkelman, “In vivo measurements of NMR relaxation times,” Mag. Res. Med. 2, 1–13 (1985).

    Google Scholar 

  20. G. R. Cherryman, A. P. Bayliss, P. W. Brunt, J. F. Calder, J. A. Harvey, J. K. Hussey, A. F. MacDonald, N. A. G. Mowat, E. M. Robertson, P. F. Sharp, J. J. Shrimankar, J. J. Simpson, T. S. Sinclair, F. W. Smith, J. Weir, and J. R. Mallard, “Magnetic resonance imaging of parenchymal liver disease: A comparison with ultrasound, radionuclide scintigraphy, and x-ray computed tomography,” Clin. Radiol. 38, 495–502 (1987).

    Article  Google Scholar 

  21. R. J. Johnson, J. P. R. Jenkins, I. Isherwood, R. D. James, and P. F. Schofield, “Quantitative magnetic resonance imaging in rectal carcinoma,” Brit. J. Radiol. 60, 761–764 (1987).

    Article  PubMed  CAS  Google Scholar 

  22. D. G. Norris, “Phase-encoded NMR flow imaging,” Proc, 3rd Ann. Meet Soc. Magn. Res. in Med., New York, pp. 559–560 (1984).

    Google Scholar 

  23. D. G. Norris and J. M. S. Hutchison, “Gated cardiac imaging using low-field NMR,” Phys. Med. Biol. 31, 779–787 (1986).

    Article  PubMed  CAS  Google Scholar 

  24. T. W. Redpath and R. A. Jones, “FADE—A new fast imaging sequence,” Magn. Res. Med. 6, 224–234 (1988).

    Article  CAS  Google Scholar 

  25. M. J. Metcalfe, T. Redpath, S. Walton, and F. W. Smith, “Low-field cine-MRI in mixed aortic valve disease,” Magn. Res. Imaging 7, Suppl. No. 1, p. 92 (1989).

    Google Scholar 

  26. V. J. Weeden, R. A. Meuli, R. R. Edelman, S. C. Geller, L. R. Frank, T. J. Brady, and B. R. Rosen, “Projective imaging of pulsatile flow with magnetic resonance,” Science 230, 946––948

    Google Scholar 

  27. D. G. Norris, R. A. Jones, and J. M. S. Hutchison, “Projective Fourier angiography,” Proc. 3rd Ann. Meet. Eur. Soc. Magn. Res. in Med. and Biol., University of Aberdeen, pp. 183–184 Published by European Society for Magnetic Resonance in Medicine and Biology, Geneva, Switzerland.

    Google Scholar 

  28. D. G. Norris, “NMR Flow Imaging,” Ph.D. Thesis, University of Aberdeen (1987).

    Google Scholar 

  29. J. P. Ridgway, L. W. Turnbull, and M. A. Smith, “Demonstration of pulsatile cerebrospinal- fluid flow using magnetic resonance phase imaging,” Brit. J. Radiol. 60, 423-–427 (1987).

    Google Scholar 

  30. P. Cook and J. R. Mallard, “An electron-spin resonance cavity for the detection of free radicals in the presence of water,” Nature 198, 145–147 (1963).

    Article  CAS  Google Scholar 

  31. J. R. Mallard and M. Kent, “Electron spin resonance in surviving rat tissues,” Nature 210, 588–591 (1966).

    Article  PubMed  CAS  Google Scholar 

  32. J. R. Mallard and M. Kent, “Electron spin resonance in biological tissues,” Phys. Med. Biol. 14, 373–396 (1969).

    Article  PubMed  CAS  Google Scholar 

  33. J. M. S. Hutchison and J. R. Mallard, “Electron spin resonance spectrometry on the whole mouse in vivo: A 100 MHz spectrometer,” J. Phys. E: Sci. Instrum. 4, 237–239 (1971).

    Article  CAS  Google Scholar 

  34. J. R. Mallard and T. A. Whittingham, “Dielectric absorption of microwaves in human tissues,” Nature 218, 366–367 (1968).

    Article  PubMed  CAS  Google Scholar 

  35. L. J. Berliner and H. Fujii, “EPR imaging of diffusional processes in biologically relevant polymers,” J. Magn. Reson. 69, 68–72 (1986).

    CAS  Google Scholar 

  36. M. M. Maltempo, S. S. Eaton, and G. R. Eaton, “Spectral-spatial two-dimensional EPR imaging,” J. Magn. Reson. 72, 449–455 (1987).

    CAS  Google Scholar 

  37. D. J. Lurie, D. M. Bussell, L. H. Bell, and J. R. Mallard, “Proton-electron double magnetic resonance imaging of free radical solutions,” J. Magn. Reson. 76, 366–370 (1988).

    CAS  Google Scholar 

  38. J. B. Aguayo, S. J. Blackband, J. Schoeniger, M. A. Mattingly, and M. Hintermann, “NMR imaging of a single cell: The NMR microscope,” Nature 322, 190–191 (1986).

    Article  PubMed  CAS  Google Scholar 

  39. .M. A. Foster, personal communication (1987).

    Google Scholar 

  40. Z. H. Cho, C. B. Ahn, S. C. Juh, H. G. Lee, J. H. Yi, and J. M. Jo, “Some experiences on a 4 µm NMR microscopy,” Proc. Soc. of Mag. Reson. in Med. 6th Annual Meeting, New York, p. 233 (1987). Published by Society of Magnetic Resonance in Medicine, Berkeley, California.

    Google Scholar 

  41. G. A. Johnson, S. A. Suddarth, P. B. Roemer, G. P. Cofer, W. A. Edelstein, and R. W. Redington, “MR microscopy at 7.0 T,” Proc. Soc. of Mag. Res. in Med., 6th Annual Meeting, New York, p. 23 (1987). Published by Society of Magnetic Resonance in Medicine, Berkeley, California.

    Google Scholar 

  42. M. D. Hollet, G. P. Cofer, R. R. Maronpot, and G. A. Johnson, “Implanted RF coils for MR microscopy,” Proc. Soc. of Mag. Reson. in Med. 6th Annual Meeting, New York, p. 467 (1987). Published by Society of Magnetic Resonance in Medicine, Berkeley, California.

    Google Scholar 

  43. J. M. S. Hutchison, personal communication (1987).

    Google Scholar 

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© 1990 Plenum Press, New York

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Mallard, J.R. (1990). Prospects for NMR Microscopy. In: Duke, P.J., Michette, A.G. (eds) Modern Microscopies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1467-7_8

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  • DOI: https://doi.org/10.1007/978-1-4613-1467-7_8

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