Abstract
In the United States, the use of platelet transfusions increased progressively during the 1980’s [1]. However, in many centres including our own at the Perm-Jersey Region of the American Red Cross, this use has maintained a plateau during the first half of the 1990’s. Part of the explanation for this change may be the gradual adoption of a more stringent trigger for prophylactic platelet transfusion. The purpose of this paper is to review what is known about the pathophysiology of severe thrombocytopenia and the clinical data relevant to its management.
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References
Surgenor DM, Wallace EL, Hao SH, Chapman RH. Collection and transfusion of blood in the United States, 1982–1988. N Engl J Med 1990;322:1646–51.
Hirsch Gardner FH. The transfusion of human blood platelets: With a note on the transfusion of granulocytes. J Lab Clin Med 1952;39:556–59.
Slichter SJ. Controversies in platelet transfusion therapy. Ann Rev Med 1980;31:509–50.
Hanson SR, Slichter SJ. Platelet kinetics in patients with bone marrow hypoplasia: Evidence for fixed platelet requirement. Blood 1985;56:1105–9.
Aursnes I. Blood platelet production and red cell leakage to lymph during thrombocytopenia. Scand J Haematol 1974;13:184–95.
Roy A J, Djerassi I. Effects of platelet transfusions: Plug formation and maintenance of vascular integrity. Proc Soc Exp Bio and Med 1972;139:137–42.
Gaydos LA, Freireich EJ, Mantel N. The quantitative relation between platelet count and hemorrhage in patients with acute leukemia. N Engl J Med 1962;266:905–9.
Freireich EJ, Kliman A, Gaydos LA, et al. Response to repeated platelet transfusion from the same donor. Ann Intern Med 1963;59:277–87.
Beutler E. Platelet transfusions: The 20000/μl trigger. Blood 1993;81:1411–13.
Gmur J, Burger J, Schanz U, et al. Safety of stringent prophylactic platelet transfusion policy for patients with acute leukemia. Lancet 1991;338:1223–26.
McVay PA, Toy PTCY. Lack of increased bleeding after liver biopsy in patients with mild hemostatic abnormalities. Amer J Clin Path 1990;94:747–53.
McVay PA, Toy PTCY. Lack of increased bleeding after paracentesis and thoracentesis in patients with mild coagulation abnormalities. Transfusion 1991;31:164–71.
Murphy S. Platelet transfusion. Prog Haemostasis and Thrombosis 1976;3:289–310.
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© 1996 Kluwer Academic Publishers
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Murphy, S. (1996). Platelets: What Qualities and Characteristics do Justify the Need for Transfusion?. In: Sibinga, C.T.S., Das, P.C., Snyder, E.L. (eds) Trigger Factors in Transfusion Medicine. Developments in Hematology and Immunology, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1287-1_9
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DOI: https://doi.org/10.1007/978-1-4613-1287-1_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8550-2
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