Effect of Diabetes on Protein Synthesis in the Myocardium
Protein turnover in muscle represents the net result of synthesis of new protein from a precursor pool of amino acids and the degradation of contractile, regulatory and other proteins into their constituent amino acids. In muscle, an array of hormonal, mechanical, and metabolic factors influence protein synthesis and degradation. Insulin, for example, is a potent stimulus of protein turnover increasing synthesis and attenuating degradation [1,2]. Fractional synthesis (Ks) and degradation (Kd) rate represent the fraction of the available precursor that is synthesized into protein or the protein product which is degraded into amino acids, respectively. Fractional synthesis rate is often expressed as a percent of the amino acid precursor pool utilized over time.
KeywordsProtein Turnover Diabetic Cardiomyopathy Diabetic Heart Precursor Pool Fractional Synthesis Rate
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