Abstract
Screening for a malignant disease is an attempt to find an asymptomatic and curable disease before it develops into one that is both symptomatic and incurable. The success of such a venture depends upon the sensitivity and specificity of the screening tool used, the extent to which the target population participates in the screening program, the ease with which the asymptomatic disease may be cured, and the likelihood that the asymptomatic disease will progress into an advanced-stage malignancy. Neuroblastoma is likely to be the only pediatric malignancy subject to a screening trial, since the tumor commonly secretes chemicals that can be detected in urine, the disease is of relatively high frequency (exceeded only by hypothyroidism among diseases currently screened for in the early newborn period), and, when present in advanced form in older infants, it is a disease that is extremely difficult to cure.
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Bernstein, M.L., Woods, W.G. (1996). Screening for Neuroblastoma. In: Miller, A.B. (eds) Advances in Cancer Screening. Cancer Treatment and Research, vol 86. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1265-9_11
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DOI: https://doi.org/10.1007/978-1-4613-1265-9_11
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