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Interleukin-6: biologic properties and role in lymphoproliferative disorders

  • John F. Seymour
  • Razelle Kurzrock
Part of the Cancer Treatment and Research book series (CTAR, volume 84)

Abstract

Interleukin-6 (IL-6) is a cytokine that exemplifies the multifunctional nature common to all interleukins [1]. Due to its broad range of actions in many systems, IL-6 has been and remains the focus of intense investigation in a number of diverse research fields. Indeed, prior to its complete characterization, the molecule was variously referred to as interferon (IFN) — β2 [2], B-cell stimulatory factor 2 [3], human hybridomaplasmacytoma growth factor [4], or hepatocyte-stimulatory factor [5]. Although such functional designations clearly and succintly conveyed a single specific action and were historically very useful, they initially led to some confusion among researchers, and it was not until the determination of the amino-acid sequence of each of these ‘factors’ that their common identity was recognized and the uniform use of the designation IL-6 was adopted (reviewed in [6]). With the more rapid cloning and production of recombinant molecules, such confusion with terminology rarely exists with cytokines and growth factors discovered in more recent years.

Keywords

Multiple Myeloma Lymphoproliferative Disorder Human Myeloma Cell Diffuse Large Cell Lymphoma Autocrine Role 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers, Boston 1996

Authors and Affiliations

  • John F. Seymour
  • Razelle Kurzrock

There are no affiliations available

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