Primitive hematopoietic stem and progenitor cells in human umbilical cord blood: an alternative source of transplantable cells

  • Hal E. Broxmeyer
Part of the Cancer Treatment and Research book series (CTAR, volume 84)

Abstract

All the circulating blood cell elements are produced by a set of primitive cells termed hematopoietic stem and progenitor cells. Each category is considered to be hierarchical in nature, with cells from the most immature to mature being produced in a catenated fashion. Conceptually, the earliest subset of cells would be the long-term marrow-repopulating stem cell (LTMRSC). This cell would be considered to have the greatest degree of self-renewal capacity and would be the cell type that one would like to make sure was in the tissue source of transplantable cells for long-term repopulation of the blood system of the recipient. It is also this cell that would be the one investigators would like to use in a gene therapy setting for long-term expression of newly integrated genetic material by gene transfer. While the LTMRSC is inferred from animal studies, particularly those studies in mice in which serial transplantation of marrow cells from mouse to mouse to repopulate the blood system is assessed, it is not clear yet whether there is a quantitative assay for this cell in the human system [1]. The LTMRSC gives rise to more mature cells within the stem cell compartment, which can be defined by more limited cell renewal capacity.

Keywords

Clay Lymphoma Leukemia Sedimentation Adenosine 

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© Kluwer Academic Publishers, Boston 1996

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  • Hal E. Broxmeyer

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