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MLL fusion genes in the 11q23 acute leukemias

  • James R. Downing
  • A. Thomas Look
Part of the Cancer Treatment and Research book series (CTAR, volume 84)

Abstract

Remarkable progress has been made over the last five years in defining the molecular pathogenesis of the acute leukemias. Of the many leukemia-specific cytogenetic abnormalities that have been identified to date, structural lesions within the 11q23 chromosomal band are among the most common [1–4]. Translocations, deletions, and inversions within 11q23 have been detected in a variety of hematopoietic malignancies, including 7%–10% of the acute lymphoblastic leukemias (ALLs), 5%–6% of the acute myeloblasts leukemias (AMLs), and as many as 85% of secondary leukemias occurring in patients treated with topoisomerase II inhibitors [2,3,5–8]. Incidence rates of 11q23 translocations are strikingly high in infants (80% of ALL cases and 45% of AML), making these rearrangements the most common cytogenetic abnormalities in acute leukemias of this age group [9–11]. A number of different reciprocal chromosome bands have been shown to participate in balanced 11q23 translocations, including 1p32, 1q21, 2p21, 4q21, 5q31, 6q27, 7p15, 9p22, 10q12, 15q15, 16p13, 17q21, 19pl3, and Xql3, with the most common translocations being t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23; p13) [1]. Although some of these rearrangements are found almost exclusively in ALL (e.g., t(4;11)) or AML (e.g., t(9;11)), the majority have been observed in both myeloid and lymphoid leukemias, suggesting transformation of a pluripotent progenitor cell [1,12–16].

Keywords

Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Acute Leukemia Breakpoint Cluster Region 11q23 Translocation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Kluwer Academic Publishers, Boston 1996

Authors and Affiliations

  • James R. Downing
  • A. Thomas Look

There are no affiliations available

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