Deletion of chromosome 5 (5q-) in leukemia: current knowledge

  • Lalitha Nagarajan
Part of the Cancer Treatment and Research book series (CTAR, volume 84)


Chromosomal abnormalities associated with distinct subsets of human leukemia suggest a link between specific genetic alterations and clinical outcome. A tight correlation between the cytogenetic anomaly and the progression of the disease indicates a direct cause and effect relationship between the genotype and the disease phenotype. In recent years, molecular cloning of genes residing at chromosomal translocation breakpoints of t(15:17), t(8:21), and inv(16), inv(3) has led to an understanding of the wide phenotypic variations observed in acute myelogenous leukemia.


Acute Myelogenous Leukemia Refractory Anemia Excess Blast Early Growth Response Gene Refractory Anemia With Ringed Sideroblasts 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Kluwer Academic Publishers, Boston 1996

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  • Lalitha Nagarajan

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