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Deletion of chromosome 5 (5q-) in leukemia: current knowledge

  • Lalitha Nagarajan
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 84)

Abstract

Chromosomal abnormalities associated with distinct subsets of human leukemia suggest a link between specific genetic alterations and clinical outcome. A tight correlation between the cytogenetic anomaly and the progression of the disease indicates a direct cause and effect relationship between the genotype and the disease phenotype. In recent years, molecular cloning of genes residing at chromosomal translocation breakpoints of t(15:17), t(8:21), and inv(16), inv(3) has led to an understanding of the wide phenotypic variations observed in acute myelogenous leukemia.

Keywords

Acute Myelogenous Leukemia Refractory Anemia Excess Blast Early Growth Response Gene Refractory Anemia With Ringed Sideroblasts 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Knudson AG (1978). Retinoblastoma: a prototypic hereditary neoplasm. Semin Oncol 5:57–60.PubMedGoogle Scholar
  2. 2.
    Knudson AG (1993). Antioncogenes and human cancer. Proc Natl Acad Sci USA 90:10914–10921.PubMedCrossRefGoogle Scholar
  3. 3.
    Van den Berghe H, Cassiman JJ, David G, Fryns JP, Sokal G (1974). Distinct haematological disorder with deletion of long arm of No. 5 chromosome. Nature 251:437–438.PubMedCrossRefGoogle Scholar
  4. 4.
    Le Beau MM, Albain KS, Larson RA, Vardiman JW, Davis EM, Blough RR, Golomb HM, Rowley JD (1986). Clinical and cytogenetic correlations in 63 patients with therapy related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes No. 5 and 7. J Clin Oncol 4:325.PubMedGoogle Scholar
  5. 5.
    Van den Berghe H, Vermaelen K, Mecucci C, Barbieri D, Tricot G (1985). The 5q- anomaly. Cancer Genet Cytogenet 17:189–255.PubMedCrossRefGoogle Scholar
  6. 6.
    Nimer SD, Golde DW (1987). The 5q- abnormality. Blood 70:1705–1712.PubMedGoogle Scholar
  7. 7.
    Mecucci C, van den Berghe H (1992). Cytogenetics. Hematol/Oncol Clin North Am 6:523–541.Google Scholar
  8. 8.
    Boultwood J, Lewis S, Wainscoat JS (1994). The 5q- syndrome. Blood 84:3253–3260.PubMedGoogle Scholar
  9. 9.
    Nagarajan L (in press). Molecular analysis of 5q- chromosome. Leukemia Lymphoma.Google Scholar
  10. 10.
    Estey EH, Keating MJ, Dixon DO, Trujillo JM, McCredie KB, Freireich EJ (1987). Karyotype is prognostically more important than the FAB system’s distinction between myelodysplastic syndrome and acute myelogenous leukemia. Hematol Pathol 1:203–208.PubMedGoogle Scholar
  11. 11.
    Keating MJ, Cork A, Broach Y, Smith T, Walters RS, McCredie KB, Trujillo ∫, Freireich EJ (1987). Towards a clinically relevant cytogenetic classification of acute myelogenous leukemia. Leukemia Res 11:119–133.CrossRefGoogle Scholar
  12. 12.
    Pedersen B, Jensen IM (1991). Clinical and prognostic implications of chromosome 5q deletions: 96 high resolution studied patients. Leukemia 5:566–573.PubMedGoogle Scholar
  13. 13.
    Warrington JA, Hall LV, Hinton LM, Miller JN, Wasmuth JJ, Lovett M (1991). A radiation hybrid map of 13 loci on the long arm of chromosome 5. Genomics 11:701–708.PubMedCrossRefGoogle Scholar
  14. 14.
    Warrington JA, Bailey SK, Armstrong E, Aprelikova O, Alitalo K, Dolganov GM, Wilcox A, Sikela J, Wolf SF, Lovett M, Wasmuth JJ (1992). A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor or neurotransmitter receptor genes to the distal region of the long arm of chromosome 5. Genomics 13:803–808.PubMedCrossRefGoogle Scholar
  15. 15.
    Nagarajan L, Lange B, Cannizzaro L, Finan J, Nowell PC, Huebner K (1990). Molecular anatomy of a 5q interstitial deletion. Blood 75:82–87.PubMedGoogle Scholar
  16. 16.
    Huebner K, Nagarajan L, Besa E, Angert E, Lange BJ, Cannizzaro LA, van den Berghe H, Santoli D, Finan J, Croce CM, Nowell PC (1990). Order of genes on human chromosome 5q with respect to 5q interstitial deletions. Am J Hum Genet 46:26–36.PubMedGoogle Scholar
  17. 17.
    Nagarajan L, Zavadil J, Claxton D, Lu X, Fairman J, Warrington JA, Wasmuth JJ, Chinault AC, Sever CE, Slovak ML, Willman CL, Deisseroth AB (1994). Consistent loss of the D5S89 locus mapping telomeric to the interleukin gene cluster and centromeric to EGR-1 in patients with 5q- chromosome. Blood 83:199–208.PubMedGoogle Scholar
  18. 18.
    Fairman J, Claxton D, Willman CL, Deisseroth AB, Nagarajan L (1994). Development of a sensitive PCR to detect allele loss in a model hematopoietic neoplasm. PCR Meth Appl 4:6–12.Google Scholar
  19. 19.
    Le Beau MM, Espinosa R III, Neuman WL, Stock W, Roulston D, Larson RA, Keinanen M, Westbrook CA (1993). Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases. Proc Natl Acad Sci USA 90:5484–5488.PubMedCrossRefGoogle Scholar
  20. 20.
    Boultwood J, Fidler C, Lewis S, Kelly S, Sheridan H, Littlewood TJ, Buckle VJ, Wainscoat JS (1994). Molecular mapping of uncharacteristically small 5q deletions in two patients with the 5q- syndrome: delineation of the critical region on 5q and identification of a 5q- breakpoint. Genomics 19:425–432.PubMedCrossRefGoogle Scholar
  21. Nagarajan L, Zhao L, Lu X, Warrington JA, Wasmuth JJ, Siciliano M, Deisseroth AB, Liang JC (1994). 5q- chromosome: evidence for complex interstitial breaks in a case of refractory anemia with excess blasts. Cancer Genet Cytogenet 74:8–12.Google Scholar
  22. 22.
    Saltman DL, Dolganov GM, Warrington JA, Wasmuth JJ, Lovett M (1993). A physical map of 15 loci on human chromosome 5q23–33 by two-color fluorescent in situ hybridization. Genomics 16:726–732.PubMedCrossRefGoogle Scholar
  23. 23.
    Kroef MJPL, Fibbe WE, Mout R, Jansen RPM, Haak HL, Wessels JW, Van Kamp H, Willemze R, Landegent JE (1993). Myeloid but not lymphoid cells carry the 5q deletion: polymerase chain reaction analysis of loss of heterozygosity using mini-repeat sequences on highly purified cell fractions. Blood 81:1849–1854.PubMedGoogle Scholar
  24. 24.
    Rosenbloom B, Schreck R, Koeffler HP (1992). Therapy-related myelodysplastic syndromes. Hematol/Oncol Clin North Am 6:707–722.Google Scholar
  25. 25.
    Gilliland DG, Perrin S, Sakamoto KM, Bunn HF (1991). Analysis of EGR-1 and other relevant genes in patients with 5q- syndrome. Blood 78:333a.Google Scholar
  26. 26.
    Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA (1991). Interferon regulatory factor 1 is myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition. Cell Growth Differ 2:401–407.PubMedGoogle Scholar
  27. 27.
    Harada H, Kitagawa M, Tanaka N, Yamamoto H, Kharada K, Ishihara M, Taniguchi T (1993). Anti-oncogenic potentials of interferon regulatory factors -1 and -2. Science 259:971–973.PubMedCrossRefGoogle Scholar
  28. 28.
    Willman C, Sever C, Pallavicini M, Harada H, Tanaka N, Slovak M, Yamamoto H, Harada K, List A, Taniguchi T (1993). Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science 259:968–971.PubMedCrossRefGoogle Scholar
  29. 29.
    Boultwood J, Fidler C, Lewis S, MacCarthy A, Sheridan H, Kelly S, Oscier D, Buckle, VJ, Wainscoat JS (1993). Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q-chromosome in some patients with 5q- syndrome. Blood 82:2611–2616.PubMedGoogle Scholar
  30. 30.
    Boultwood J, Rack K, Kelly S, Madden J, Sakaguchi AY, Wang LM, Oscier DG, Buckle VJ, Wainscoat JS (1991). Loss of both FMS alleles in patients with preleukemia and a chromosome 5 deletion. Proc Natl Acad Sci USA 88:6176–6180.PubMedCrossRefGoogle Scholar
  31. 31.
    Golub TR, Barker GF, Lovett M, Gilliland DG (1994). Fusion of PDGF receptor to β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307–316.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1996

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  • Lalitha Nagarajan

There are no affiliations available

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