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Nuclear oncogenes in breast cancer

  • Chapter
Mammary Tumor Cell Cycle, Differentiation, and Metastasis

Part of the book series: Cancer Treatment and Research ((CTAR,volume 83))

Abstract

The prevailing view of cancer is that it is a disease resulting from a number of sequential mutations in critical growth regulatory genes [1]. In the past 20 years it has been discovered that retroviral transforming genes, oncogenes, were actually modified growth regulatory genes derived from the viral host genome. In all cases the modifications in the viral oncogene yielded a growth regulatory gene that exhibited enhanced or unregulated activity when compared with its normal cellular counterpart. Growth regulatory genes may act to enhance or inhibit growth and encompass transactivators, including the steroid/retinoid/thyroid hormone receptors, cell cycle regulators, tumor suppressors, growth factors, and growth factor receptors.

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Authors
  1. Don Dubik
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  2. Peter H. Watson
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  3. Marcello Venditti
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  4. Robert P. C. Shiu
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Editor information

Editors and Affiliations

  1. Departments of Cell Biology and Pharmacology, Lombardi Cancer Center, The Research Building, 3970 Reservoir Road, 20007, Washington, DC, USA

    Robert B. Dickson PHD

  2. Departments of Medicine and Pharmacology, Lombardi Cancer Center, The Research Building, 20007, 3970 Reservoir Road, Washington, CD, USA

    Marc E. Lippman MD

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© 1996 Kluwer Academic Publishers

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Dubik, D., Watson, P.H., Venditti, M., Shiu, R.P.C. (1996). Nuclear oncogenes in breast cancer. In: Dickson, R.B., Lippman, M.E. (eds) Mammary Tumor Cell Cycle, Differentiation, and Metastasis. Cancer Treatment and Research, vol 83. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1259-8_9

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  • DOI: https://doi.org/10.1007/978-1-4613-1259-8_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8536-6

  • Online ISBN: 978-1-4613-1259-8

  • eBook Packages: Springer Book Archive

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