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Mammary Tumor Cell Cycle, Differentiation, and Metastasis pp 141–170Cite as

Cyclins and breast cancer

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 83))

Abstract

There is unequivocal evidence that cancer is a disease resulting from abnormal gene function [1]. In the past 20 years, up to 100 positively acting oncogenes [2] have been identified, along with a dozen negatively acting tumor suppressor genes [3]. The proteins encoded by the majority of these genes are components of growth regulatory pathways, that is, they are growth factor receptors, signaling molecules, transcription factors, and proteins involved in entry into, progression through, and exit from the cell cycle. It is not surprising, therefore, that the cyclins, a family of molecules that play a central role in regulating progression through the cell cycle, have been implicated in oncogenesis.

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Authors
  1. Kimberley J. E. Sweeney
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  2. Elizabeth A. Musgrove
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  3. Colin K. W. Watts
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  4. Robert L. Sutherland
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Editors and Affiliations

  1. Departments of Cell Biology and Pharmacology, Lombardi Cancer Center, The Research Building, 3970 Reservoir Road, 20007, Washington, DC, USA

    Robert B. Dickson PHD

  2. Departments of Medicine and Pharmacology, Lombardi Cancer Center, The Research Building, 20007, 3970 Reservoir Road, Washington, CD, USA

    Marc E. Lippman MD

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© 1996 Kluwer Academic Publishers

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Sweeney, K.J.E., Musgrove, E.A., Watts, C.K.W., Sutherland, R.L. (1996). Cyclins and breast cancer. In: Dickson, R.B., Lippman, M.E. (eds) Mammary Tumor Cell Cycle, Differentiation, and Metastasis. Cancer Treatment and Research, vol 83. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1259-8_8

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  • DOI: https://doi.org/10.1007/978-1-4613-1259-8_8

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