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Mammary Tumor Cell Cycle, Differentiation, and Metastasis pp 353–367Cite as

Stromelysin-3 and other stromelysins in breast cancer: Importance of epithelial-stromal interactions during tumor progression

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 83))

Abstract

Stromelysins belong to the matrix metalloproteinase (MMP, also known as matrixin) family, extracellular proteolytic enzymes that are believed to be physiological mediators of tissue remodeling processes during development, involution, and tissue repair [1,2]. In agreement with this concept, MMPs are capable of degrading most macromolecular components found in or associated with the extracellular matrix (ECM) [1–4]. MMPs have also been implicated in pathological tissue remodeling processes, including those associated with cancer progression [5]. Although it has been proposed that they may be involved in the initiation of oncogenesis [6], MMPs should be better regarded as modulators of cancerous processes, thus contributing to tumor invasion and metastasis [5,7–9].

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  1. Paul Basset
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  2. Jean-Pierre Bellocq
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  3. Patrick Anglard
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  4. Marie-Pierre Chenard
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Editor information

Editors and Affiliations

  1. Departments of Cell Biology and Pharmacology, Lombardi Cancer Center, The Research Building, 3970 Reservoir Road, 20007, Washington, DC, USA

    Robert B. Dickson PHD

  2. Departments of Medicine and Pharmacology, Lombardi Cancer Center, The Research Building, 20007, 3970 Reservoir Road, Washington, CD, USA

    Marc E. Lippman MD

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© 1996 Kluwer Academic Publishers

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Basset, P. et al. (1996). Stromelysin-3 and other stromelysins in breast cancer: Importance of epithelial-stromal interactions during tumor progression. In: Dickson, R.B., Lippman, M.E. (eds) Mammary Tumor Cell Cycle, Differentiation, and Metastasis. Cancer Treatment and Research, vol 83. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1259-8_17

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