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Cell motility in breast cancer

  • Jason D. Kantor
  • Bruce R. Zetter
Part of the Cancer Treatment and Research book series (CTAR, volume 83)

Abstract

Tumor growth and metastasis involve a complex interaction between tumor and nontumor cells, characterized by alterations in the regulation of cell behavior. The earliest stage of tumor formation is proliferation. Through genetic mutations, a cell or group of cells becomes refractory to normal growth regulation. The resultant mass of cells exerts pressure on surrounding tissue but does not cross tissue boundaries. Noninvasive tumors have been termed benign and can often be easily removed. The progression from a benign to a malignant tumor entails a series of steps involving both tumor cells and the surrounding tissue.

Keywords

Hepatocyte Growth Factor Breast Tumor Cell Human Breast Tumor Nucleoside Diphosphate Kinase Fetal Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Gimbrone M Jr, Leapman SB, Cotran RS, Folkman J (1972) Tumor dormancy in vivo by prevention of neovascularization. J Exp Med 136:261–276.PubMedGoogle Scholar
  2. 2.
    Butler TP, Gullino PM (1975) Quantitation of cell shedding into efferent blood of mammary adenocarcinoma. Cancer Res 35:512–516.PubMedGoogle Scholar
  3. 3.
    Downey GP (1994). Mechanisms of leukocyte motility and Chemotaxis. Curr Opin Immunol 6:113–124.PubMedGoogle Scholar
  4. 4.
    Cerra RF, Nathanson SD (1989) Organ-specific chemotactic factors present in lung extracellular matrix. J Surg Res 46:422–426.PubMedGoogle Scholar
  5. 5.
    Ozaki T, Yoshida K, Ushijima K, Hayashi H (1971) Studies on the mechanisms of invasion in cancer. II. In Vivo effects of a factor chemotactic for cancer cells.Google Scholar
  6. Ozaki T, Yoshida K, Ushijima K, Hayashi H (1971) Int J Cancer 7:93–100.PubMedGoogle Scholar
  7. 6.
    Hsijanen ES, Terranova VP (1985) Migration of tumor cells to organ-derived chemoattractants. Cancer Res 45:3517–3521.Google Scholar
  8. 7.
    Koch AE, Harlow LA, Haines GK, Amento EP, Unemori EN, Wong WL, Pope RM, Ferrara N (1994) Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol 152:4149–4156.PubMedGoogle Scholar
  9. 8.
    Weidner KM, Hartmann G, Sachs M, Birchmeier W (1993) Properties and functions of scatter factor/hepatocyte growth factor and its receptor c-Met [review]. Am J Respir Cell Mol Biol 8:229–237.PubMedGoogle Scholar
  10. 9.
    Weidner KM, Hartmann G, Naldini L, Comoglio PM, Sachs M, Fonatsch C, Rieder H, Birchmeier W (1993) Molecular characteristics of HGF-SF and its role in cell motility and invasion [review]. EXS 65:311–328.PubMedGoogle Scholar
  11. 10.
    Nabi IR, Watanabe H, Raz A (1992) Autocrine motility factor and its receptor: Role in cell locomotion and metastasis [review]. Cancer Metastasis Rev 11:5–20.PubMedGoogle Scholar
  12. 11.
    Brandley BK, Schnaar RL (1988) Covalent attachment of an Arg-Gly-Asp sequence peptide to derivatizable Polyacrylamide surfaces: Support of fibroblast adhesion and long-term growth. Anal Biochem 172:270–278.PubMedGoogle Scholar
  13. 12.
    Brandley BK, Schnaar RL (1989) Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptide. Dev Biol 135:74–86.PubMedGoogle Scholar
  14. 13.
    Brandley BK, Shaper JH, Schnaar RL (1990) Tumor cell haptotaxis on immobilized N-acetylglucosamine gradients. Dev Biol 140:161–171.PubMedGoogle Scholar
  15. 14.
    Manske M, Bade EG (1994) Growth factor-induced cell migration: Biology and methods of analysis. Int Revi Cyto 155:49–96.Google Scholar
  16. 15.
    Mohler JL, Partin AW, Coffey DS (1987) Prediction of metastatic potential by a new grading system of cell motility: Validation in the Dunning R-3327 prostatic adenocarcinoma model. J Urol 138:168–170.PubMedGoogle Scholar
  17. 16.
    Doyle GM, Sharief Y, Mohler JL (1992) Prediction of metastatic potential by cancer cell motility in the Dunning R-3327 prostatic adenocarcinoma in vivo model. J Ural 147:514–518.Google Scholar
  18. 17.
    Mohler JL, Partin AW, Isaacs WB, Coffey DS (1987) Time lapse videomicroscopic identification of Dunning R-3327 adenocarcinoma and normal rat prostate cells. J Urol 137:544–547.PubMedGoogle Scholar
  19. 18.
    Partin AW, Mohler JL, Coffey DS (1992) Cell motility as an index of metastatic ability in prostate cancers: Results with an animal model and with human cancer cells. Cancer Treat Res 59:121–130.PubMedGoogle Scholar
  20. 19.
    Albrecht-Buehler, G (1977) The phagokinetic tracks of 3T3 cells. Cell 11:395–404.PubMedGoogle Scholar
  21. 20.
    Zigmond, SH, Hirsch JG (1973) Leukocyte locomotion and Chemotaxis: New methods for evaluation, and demonstration of a cell-derived factor. J Exp Med 137:387–410.PubMedGoogle Scholar
  22. 21.
    McCarthy JB, Palm SL, Furcht LT (1983) Migration by haptotaxis of a Schwann cell tumor line to the basement membrane glycoprotein laminin. J Cell Biol 97:772–777PubMedGoogle Scholar
  23. 22.
    Stracke ML, Krutzsch, HC, Unsworth EJ, Arestad A, Cioce V, Schiffmann E, Liotta LA (1992) Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J Biol Chemi 267:2524–2529.Google Scholar
  24. 23.
    Liotta LA, Mandler R, Murano G, Katz DA, Gordon RK, Chiang PK, Schiffmann E (1986) Tumor cell autocrine motility factor. Proc Natl Acad Sci USA 83:3302–3306.PubMedGoogle Scholar
  25. 24.
    Atnip KD, Carter LM, Nicolson GL, Dabbous MK (1987) Chemotactic response of rat mammary adenocarcinoma cell clones to tumor-derived cytokines. Biochem Biophys Res Commun 146:996–1002.PubMedGoogle Scholar
  26. 25.
    Guirguis R, Margulies I, Taraboletti G, Schiffmann E, Liotta L (1987) Cytokine-induced pseudopodial protrusion is coupled to tumour cell migration. Nature 329:261–263.PubMedGoogle Scholar
  27. 26.
    Guirguis R, Schiffmann E, Liu B, Birkbeck D, Engel J, Liotta L (1988) Detection of autocrine motility factor in urine as a marker of bladder cancer. J Natl Cancer Inst 80:1203–1211.PubMedGoogle Scholar
  28. 27.
    Bhargava MM, Li Y, Joseph A, Jin L, Rosen EM, Goldberg ID (1993) HGF-SF: Effects on motility and morphology of normal and tumor cells [review]. EXS 65:341–349.PubMedGoogle Scholar
  29. 28.
    Seslar SP, Nakamura T, Byers SW (1993) Regulation of fibroblast hepatocyte growth factor/scatter factor expression by human breast carcinoma cell lines and peptide growth factors. Cancer Res 53:1233–1238.PubMedGoogle Scholar
  30. Rosen EM, Knesel J, Goldberg ID, Jin L, Bhargava M, Joseph A, Zitnik R, Wines J, Kelley M, Rockwell S (1994) Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor. Int J Cancer 57:706–714.Google Scholar
  31. 30.
    Byers S, Park M, Sommers C, Seslar S (1994) Breast carcinoma: A collective disorder. Breast Cancer Res Treat 31:203–215.PubMedGoogle Scholar
  32. 31.
    Weidner KM, Sachs M, Birchmeier W (1993) The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J Cell Biol 121:145–154.PubMedGoogle Scholar
  33. 32.
    Rosen EM, Grant D, Kleinman H, Jaken S, Donovan MA, Setter E, Luckett PM, Carley W, Bhargava M, Goldberg ID (1991) Scatter factor stimulates migration of vascular endothelium and capillary-like tube formation [review]. EXS 59:76–88.PubMedGoogle Scholar
  34. 33.
    Rosen EM, Grant DS, Kleinman HK, Goldberg ID, Bhargava MM, Nickoloff BJ, Kinsella JL, Polverini P (1993) Scatter factor (hepatocyte growth factor) is a potent angiogenesis factor in vivo. Symp Soc Exp Biol 47:227–234.PubMedGoogle Scholar
  35. 34.
    Bussolino F, Di Renzo MF, Ziehe M, Bocchietto E, Olivero M, Naldini L, Gaudino G, Tamagnone L, Coffer A, Comoglio PM (1992) Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 119:629–641.PubMedGoogle Scholar
  36. 35.
    Grant DS, Kleinman HK, Goldberg ID, Bhargava MM, Nickoloff BJ, Kinsella JL, Polverini P, Rosen EM (1993) Scatter factor induces blood vessel formation in vivo. Proc Natl Acad Sci USA 90:1937–1941.PubMedGoogle Scholar
  37. 36.
    Yamashita J, Ogawa M, Yamashita S, Nomura K, Kuramoto M, Saishoji T, Shin S (1994) Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer. Cancer Res 54:1630–1633.PubMedGoogle Scholar
  38. 37.
    Schor SL, Haggie JA, Durning P, Howell A, Smith L, Sellwood RA, Crowther D (1986) Occurrence of a fetal fibroblast phenotype in familiar breast cancer. Int J Cancer 37:831–836.PubMedGoogle Scholar
  39. 38.
    Haggie JA, Sellwood RA, Howell A, Birch JM, Schor SL (1987) Fibroblasts from relatives of patients with hereditary breast cancer show fetal-like behaviour in vitro. Lancet 1:1455–1457.PubMedGoogle Scholar
  40. 39.
    Schor SL, Schor AM (1990) Characterization of migration-stimulating factor (MSF): Evidence for its role in cancer pathogenesis [review]. Cancer Invest 8:665–667.PubMedGoogle Scholar
  41. 40.
    Sakakura T (1983) Epithelial-mesenchymal interactions in mammary gland development and its perturbation in relation to tumorigenesis. In Understanding Breast Cancer. MA Rich. JC Hager, P Furmanski (eds). New York: Marcel Dekker, pp 261–284.Google Scholar
  42. 41.
    Schor SL, Grey AM, Ellis I, Schor AM, Coles B, Murphy R (1993) Migration stimulating factor (MSF): Its structure, mode of action and possible function in health and disease [review]. Symp Soc Exp Biol 47:235–251.PubMedGoogle Scholar
  43. 42.
    Schor SL, Grey AM, Ellis I, Schor AM, Howell A, Sloan P, Murphy R (1994) Fetal-like fibroblasts: Their production of migration-stimulating factor and role in tumor progression. Cancer Treatm Res 71:277–298.Google Scholar
  44. 43.
    Krueger J, Ray A, Tamm I, Sehgal PB (1991) Expression and function of interleukin-6 in epithelial cells [review]. J Cell Biochem 45:327–334.PubMedGoogle Scholar
  45. 44.
    Tamm I, Cardinale I, Krueger J, Murphy JS, May LT, Sehgal PB (1989) Interleukin-6 decreases cell-cell association and increases motility of ductal breast carcinoma cells. J Exp Med 170:1649–1669.PubMedGoogle Scholar
  46. 45.
    Ebralidze A, Tulchinsky E, Grigorian M, Afanasyeva A, Senin V, Revazova E, Lukanidin E (1989) Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family. Genes Dev 3:1086–1093.PubMedGoogle Scholar
  47. 46.
    Grigorian MS, Tulchinsky EM, Zain S, Ebralidze AK, Kramerov DA, Kriajevska MV, Georgiev GP, Lukanidin EM (1993) The mtsl gene and control of tumor metastasis [review]. Gene 135:229–238.PubMedGoogle Scholar
  48. 47.
    Takenaga K, Nakamura Y, Sakiyama S (1994) Cellular localization of pEL98 protein, an S100-related calcium binding protein, in fibroblasts and its tissue distribution analyzed by monoclonal antibodies. Cell Struct Funct 19:133–141.PubMedGoogle Scholar
  49. 48.
    Barraclough R, Rudland PS (1994) The S-100-related calcium-binding protein, p9Ka, and metastasis in rodent and human mammary cells. Euro J Cancer 30A:1570–1576.Google Scholar
  50. 49.
    Davies BR, Davies MP, Gibbs FE, Barraclough R, Rudland PS (1993) Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1. Oncogene 8:999–1008.PubMedGoogle Scholar
  51. 50.
    Davies BR, Barraclough R, Davies MP, Rudland PS (1993) Production of the metastatic phenotype by DNA transfection in a rat mammary model. Cell Biol Int 17:871–879.PubMedGoogle Scholar
  52. 51.
    Takenaga K, Nakamura Y, Endo H, Sakiyama S (1994) Involvement of S100-related calcium-binding protein pEL98 (or mtsl) in cell motility and tumor cell invasion. Jpn J Cancer Res 85:831–839.PubMedGoogle Scholar
  53. 52.
    Takenaga K, Nakamura Y, Sakiyama S (1994) Expression of a calcium binding protein pEL98 (mtsl) during differentiation of human promyelocytic leukemia HL-60 cells. Biochem Biophys Res Commun 202:94–101.PubMedGoogle Scholar
  54. 53.
    Gibbs FE, Wilkinson MC, Rudland PS, Barraclough R (1994) Interactions in vitro of p9Ka, the rat S-100-related, metastasis-inducing, calcium-binding protein. J Biol Chem 269:18992–18999.PubMedGoogle Scholar
  55. 54.
    Kriajevska MV, Cardenas MN, Grigorian MS, Ambartsumian NS, Georgiev GP, Lukanidin EM (1994) Non-muscle myosin heavy chain as a possible target for protein encoded by metastasis-related mts-1 gene. J Biol Chem 269:19679–19682.PubMedGoogle Scholar
  56. 55.
    Ford HL, Chakravarty R, Salim M, Silver D, Aluiddin V, Sellers J, Zain S (1995) The mtsl gene in metastasis and motility. J Cell Biochem 19b(Suppl):7.Google Scholar
  57. 56.
    Takenaga K, Nakamura Y, Sakiyama S, Hasegawa Y, Sato K, Endo H (1994) Binding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin. J Cell Biol 124:757–768.PubMedGoogle Scholar
  58. 57.
    Steeg PS, Bevilacqua G, Kopper L, Thorgeirsson UP, Talmadge JE, Liotta LA, Sobel ME (1988) Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 80:200–204.PubMedGoogle Scholar
  59. 58.
    Kobayashi S, Iwase H, Itoh Y, Fukuoka H, Yamashita H, Kuzushima T, Iwata H, Masaoka A, Kimura N (1992) Estrogen receptor, c-erbB-2 and nm23/NDP kinase expression in the intraductal and invasive components of human breast cancers. Jpn J Cancer Res 83:859–865.PubMedGoogle Scholar
  60. 59.
    Tokunaga Y, Urano T, Furukawa K, Kondo H, Kanematsu T,. Shiku H (1993) Reduced expression of nm23-Hl, but not of nm23-H2, is concordant with the frequency of lymph-node metastasis of human breast cancer. Int J Cancer 55:66–71.PubMedGoogle Scholar
  61. 60.
    Noguchi M, Earashi M, Ohnishi I, Kinoshita K, Thomas M, Fusida S, Miyazaki I, MizukamiY (1994) nm23 and c-erbB-2 expression in invasive breast cancer. Oncol Rep 1:523–528.PubMedGoogle Scholar
  62. Noguchi M, Earashi M, Ohnishi I, Kinoshita K, Thomas M, Fusida S, Miyazaki I, MizukamiY (1994) nm23 expression versus helix pomatia lectin binding in human breast cancer metastases. Int J Oncol 4:1353–1358.PubMedGoogle Scholar
  63. 62.
    Bevilacqua G, Sobel ME, Liotta LA, Steeg PS (1989) Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res 49:5185–5190.PubMedGoogle Scholar
  64. 63.
    Noguchi M, Earashi M, Ohnishi I, Kitagawa H, Fusida S, Miyazaki I, Mizukami Y (1994) Relationship between nm23 expression and axillary and internal mammary liymph node metastases in invasive breast cancer. Oncol Rep 1:795–799.PubMedGoogle Scholar
  65. 64.
    Hennessy C, Henry JA, May FE, Westley BR, Angus B, Lennard TW (1991) Expression of the antimetastatic gene nm23 in human breast cancer: An association with good prognosis. J Natl Cancer Inst 83:281–285.PubMedGoogle Scholar
  66. 65.
    Hennessy C, Henry JA, May FE, Westley BR, Angus B, Lennard TW (1991) Expression of anti-metastatic gene nm23 [letter; comment]. Br J Cancer 63:1024.PubMedGoogle Scholar
  67. 66.
    Sastre-Garau X, Lacombe ML, Jouve M, Veron M, Magdelenat H (1992) Nucleoside diphosphate kinase/NM23 expression in breast cancer: Lack of correlation with lymph-node metastasis. Int J Cancer 50:533–538.Google Scholar
  68. 67.
    Leone A, Flatow U, VanHoutte K, Steeg PS (1993) Transfection of human nm23-Hl into the human MDA-MB-435 breast carcinoma cell line: Effects on tumor metastatic potential, colonization and enzymatic activity. Oncogene 8:2325–2333.PubMedGoogle Scholar
  69. Leone A, Flatow U, King CR, Sandeen MA, Margulies IM, Liotta LA, Steeg PS (1991) Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell 65:25–35.PubMedGoogle Scholar
  70. 69.
    Kantor JD, McCormick B, Steeg PS, Zetter BR (1993) Inhibition of cell motility after nm23 transfection of human and murine tumor cells. Cancer Res 53:1971–1973.PubMedGoogle Scholar
  71. 70.
    Postel EH, Berberich SJ, Flint SJ, Ferrone CA (1993) Human c-myc transcription factor PuF identified an nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis [see comments]. Science 261:478–480.PubMedGoogle Scholar
  72. 71.
    Postel EH, Ferrone CA (1994) Nucleoside diphosphate kinase enzyme activity of NM23-H2/PuF is not required for its DNA binding and in vitro transcriptional functions. J Biol Chem 269:8627–8630.PubMedGoogle Scholar
  73. 72.
    MacDonald NJ, De la Rosa A, Benedict MA, Freije JM, Krutsch H, Steeg PS (1993) A serine phosphorylation of nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential. J Biol Chem 268:25780–25789.PubMedGoogle Scholar
  74. 73.
    Munoz-Dorado J, Almaula N, Inouye S, Inouye M (1993) Autophosphorylation of nucleoside diphosphate kinase from Myxococcus xanthus. J Bacteriol 175:1176–1181.Google Scholar
  75. 74.
    Bominaar AA, Tepper AD, Veron M (1994) Autophosphorylation of nucleoside diphosphate kinase on non-histidine residues. FEBS Lett 353:5–8.PubMedGoogle Scholar
  76. 75.
    Lakshmi MS, Parker C, Sherbet GV (1993) Metastasis associated MTS1 and NM23 genes affect tubulin polymerisation in B16 melanomas: A possible mechanism of their regulation of metastatic behaviour of tumors. Anticancer Res 13:299–303.PubMedGoogle Scholar
  77. 76.
    Huitorel P, Simon C, Pantaloni D (1984) Nucleoside diphophate kinase from brain — Purification and effect on microtubule assembly in vitro. Eur J Biochem 144:233–241.PubMedGoogle Scholar
  78. 77.
    Melki R, Lascu I, Carlier MF, Veron M (1992) Nucleoside diphosphate kinase does not directly interact with tubulin nor microtubules. Biochem Biophys Res Commun 187:65–72.PubMedGoogle Scholar
  79. 78.
    Weinstat-Saslow D, Steeg PS (1994) Angiogenesis and colonization in the tumor metastatic process: Basic and applied advances [review]. FASEB J 8:401–407.PubMedGoogle Scholar
  80. 79.
    Folkman J (1995) Tumor Angiogenesis. In The Molecular Basis of Cancer. J Mendelsohn, PM Howley, MA Israel, LA Liotta (eds). Phiadelphia: WB Saunders, pp 206–232.Google Scholar
  81. 80.
    Folkman J, Hochberg M (1973) Self-regulation of growth in three dimentions. J Exp Med 138:745–753.PubMedGoogle Scholar
  82. 81.
    Folkman J (1994) Angiogenesis and breast cancer [editorial; comment]. J Clin Oncol 12:441–443.PubMedGoogle Scholar
  83. 82.
    Toi M, Kashitani J, Tominaga T (1993) Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma. Int J Cancer 55:371–374.Google Scholar
  84. 83.
    Toi M, Hoshina S, Takayanagi T, Tominaga T (1994) Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn J Cancer Res 85:1045–1049.PubMedGoogle Scholar
  85. 84.
    Visscher DW, Smilanetz S, Drozdowicz S, Wykes SM (1993) Prognostic significance of image morphometric microvessel enumeration in breast carcinoma. Anal Quant Cyiol Histol 15:88–92.Google Scholar
  86. 85.
    Horak ER, Leek R, Klenk N, LeJeune S, Smith K, Stuart N, Greenall M, Stepniewska K, Harris AL (1992) Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as an indicator of node metastases and survival in breast cancer. Lancet 340:1120–1124.PubMedGoogle Scholar
  87. 86.
    Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini G (1992) Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma [see comments]. J Natl Cancer Inst 84:1875–1887.Google Scholar
  88. 87.
    Gasparini G, Weidner N, Bevilacqua P, Maluta S, Dalla Palma P, Caffo O, Barbareschi M, Boracchi P, Marubini E, Pozza F (1994) Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma [see comments], J Clin Oncol 12:454–466.PubMedGoogle Scholar
  89. 88.
    Weidner N, Semple JP, Welch WR, Folkman J (1991) Tumor angiogenesis and metastasis — correlation in invasive breast carcinoma. N Engl J Med 324:1–8.Google Scholar
  90. 89.
    Harris AL, Fox S, Bicknell R, Leek R, Reif M, LeJeune S, Kaklamanis L (1994) Gene therapy through signal transduction pathways and angiogenic growth factors as therapeutic targets in breast cancer [review]. Cancer 74(Suppl): 1021–1025.PubMedGoogle Scholar
  91. 90.
    Blood CH, Zetter BR (1990) Tumor interactions with the vasculature: Angiogenesis and tumor metastasis [review]. Biochim Biophys Acta 1032:89–118.PubMedGoogle Scholar
  92. 91.
    Sholley MM, Ferguson GP, Seibel HR, Montour JL, Wilson JD (1984) Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells. Lab Invest 51:624–634.PubMedGoogle Scholar
  93. 92.
    Stokes CL, Lauffenburger DA (1991) Analysis of the roles of microvessel endothelial cell random motility and Chemotaxis in angiogenesis. J Theor Biol 152:377–403.PubMedGoogle Scholar
  94. 93.
    Harris AL, Fox S, Bicknell R, Leek R, Reif M, LeJeune S, Kaklamanis L (1994) Gene therapy through signal transduction pathways and angiogenic growth factors as therapeutic targets in breast cancer [review]. Cancer 74(Suppl):1021–1025.PubMedGoogle Scholar
  95. 94.
    Zhang H-T, Craft P, Scott PAE, Ziehe M, Weich HA, Harris AL, Bicknell R (1995) Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells. J Natl Cancer Inst 87:213–218.PubMedGoogle Scholar
  96. 95.
    Brown LF, Berse B, Jackman RW, Tognazzi K, Guidi AJ, Dvorak HF, Senger DR, Connolly JL, Schnitt SJ (1995) Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum Pathol 26:86–91.PubMedGoogle Scholar
  97. Watanabe H, Nguyen M, Schizer M, Li V, Hayes DF, Sallan S, Folkman J (1992) Basic fibroblast growth factor in human serum — A prognostic test for breast cancer. Mol Biol Cell 3(Suppl):234a.Google Scholar
  98. 97.
    Simorre-Pinatel V, Guerrin M, Chollet P, Penary M, Clamens S, Malecaze F, Plouet J (1994) Vasculotropin-VEGF stimulates retinal capillary endoethelial cells through an autocrine pathway. Invest Ophthalmol Vis Sci 35:3393–3400.PubMedGoogle Scholar
  99. 98.
    Terranova VP, DiFlorio R, Lyall RM, Hic S, Friesel R, Maciag T (1985) Human endothelial cells are chemotactic to endothelial cell growth factor and heparin. J Cell Biol 101:2330–2334.PubMedGoogle Scholar
  100. 99.
    Sato Y, Rifkin DB (1988) Autocrine activities of basic fibroblast growth factor: Regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J Cell Biol 107:1199–1205.PubMedGoogle Scholar
  101. 100.
    Yee C, Shiu PR (1986) Degradation of endothelial basement membrane by human breast cancer cell lines. Cancer Res 46:1835–1839.PubMedGoogle Scholar
  102. 101.
    Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz CM, Shafie S (1980) Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 284:67–68.PubMedGoogle Scholar
  103. 102.
    Nakajima M, Welch DR, Belloni PN, Nicolson GL (1987) Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones of differing metastatic potentials. Cancer Res 47:4869–4876.PubMedGoogle Scholar
  104. 103.
    Monteagudo C, Merino MJ, San-Juan J, Liotta LA, Stetler-Stevenson WG (1990) Immuno-histochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue. Am J Pathol 136:585–592.PubMedGoogle Scholar
  105. 104.
    Barsky SH, Togo S, Garbisa S, Liotta LA (1983) Type IV collagenase immunoreactivity in invasive breast carcinoma. Lancet 1:296–297.PubMedGoogle Scholar
  106. 105.
    D’Errico A, Garbisa S, Liotta LA, Castronovo V, Stetler-Stevenson WG, Grigiooni WF (1991) Augmentation of type IV collagenase, laminin receptor, and Ki67 proliferation antigen associated with human colon, gastric, and breast carcinoma progression. Mod Pathol 4:239–246.PubMedGoogle Scholar
  107. 106.
    Azzam HS, Arand G, Lippman ME, Thompson EW (1993) Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production. J Natl Cancer Inst 85:1758–1764.PubMedGoogle Scholar
  108. 107.
    Ponton A, Coulombe B, Skup D (1991) Decreased expression of tissue inhibitor of metalloproteinases in metastatic tumor cells leading to increased levels of collagenase activity. Cancer Res 51:2138–2143.PubMedGoogle Scholar
  109. 108.
    Mundy GR, DeMartino S, Rowe DW (1981) Collagen and collagen-derived fragments are chemotactic for tumor cells.J Clin Invest 68:1102–1105.PubMedGoogle Scholar
  110. 109.
    Johnson MD, Kim HR, Chesler L, Tsao-Wu G, Bouck N, Polverini PJ (1994) Inhibition of angiogenesis by tissue inhibitor of metalloproteinase. J Cell Physiol 160:194–202.PubMedGoogle Scholar
  111. 110.
    Murphy AN, Unsworth EJ, Stetler-Stevenson WG (1993) Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation. J Cell Physiol 157:351–358.PubMedGoogle Scholar
  112. 111.
    Pucci-Minafra I, Minafra S, Faccini AM, Alessandro R (1989) An ultrastructural evaluation of cell heterogeneity in invasive ductal carcinomas of the human breast. I. An in vivo study. J Submicrosc Cytol Pathol 21:475–488.PubMedGoogle Scholar
  113. 112.
    Pucci-Minafra I, Minafra S, Alessandro R, Faccini AM (1989) An ultrastructural evaluation of cell heterogeneity in invasive ductal carcinomas of the human breast. II. An in vitro study. J Submicrosc Cytol Pathol 21:489–499.PubMedGoogle Scholar
  114. 113.
    Pucci-Minafra I, Minafra S, Tomasino RM, Sciarrino S, Tinervia R (1986) Collagen changes in the ductal infiltrating (scirrhous) carcinoma of the human breast. A possible role played by type I trimer collagen on the invasive growth. J Submicrosc Cytol 18:795–805.PubMedGoogle Scholar
  115. 114.
    Luparello C, Sheterline P, Pucci-Minafra I, Minafra S (1991) A comparison of spreading and motility behaviour of 8701-BC breast carcinoma cells on type I, I-trimer and type V collages substrata. Evidence for a permissive effect of type I-trimer collagen on cell locomotion.J Cell Sci 100:179–185.PubMedGoogle Scholar
  116. 115.
    Atsushi Y, Anand-Apte B, Zetter B (1996) Differential endothelial migration and proliferation to basicfibroblast growth factor and vascular endothelial growth factor. Growth Factors 13:1–8.Google Scholar

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© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Jason D. Kantor
  • Bruce R. Zetter

There are no affiliations available

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