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Programmed cell death and mammary neoplasia

  • Chapter
Mammary Tumor Cell Cycle, Differentiation, and Metastasis

Part of the book series: Cancer Treatment and Research ((CTAR,volume 83))

Abstract

Normal development and maintenance of tissue size is dependent on a balance between cell proliferation and cell death. Apoptosis, or programmed cell death, plays important roles in mammary gland development, from the embryonic development of sexual dimorphism to senescent involution of the mammary gland. The involution of secretory epithelium following pregnancy and lactation is the most dramatic example of the role of apoptosis in mammary gland development. This phase of mammary gland development provides an important physiological and pathological context in which to study the programmed death of epithelium, because a failure in cell death appears to contribute to neoplastic development [1–3]. Although considerable effort has been directed toward understanding the role of cell proliferation in neoplastic development, much less is known about the process of apoptotic cell death in either the control of normal tissue homeostasis or its potential influence on neoplastic development.

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Authors
  1. Pepper J. Schedin
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  2. Larissa B. Thackray
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  3. Patricia Malone
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  4. Susan C. Fontaine
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  5. Robert R. Friis
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  6. Robert Strange
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Editor information

Editors and Affiliations

  1. Departments of Cell Biology and Pharmacology, Lombardi Cancer Center, The Research Building, 3970 Reservoir Road, 20007, Washington, DC, USA

    Robert B. Dickson PHD

  2. Departments of Medicine and Pharmacology, Lombardi Cancer Center, The Research Building, 20007, 3970 Reservoir Road, Washington, CD, USA

    Marc E. Lippman MD

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© 1996 Kluwer Academic Publishers

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Schedin, P.J., Thackray, L.B., Malone, P., Fontaine, S.C., Friis, R.R., Strange, R. (1996). Programmed cell death and mammary neoplasia. In: Dickson, R.B., Lippman, M.E. (eds) Mammary Tumor Cell Cycle, Differentiation, and Metastasis. Cancer Treatment and Research, vol 83. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1259-8_1

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  • DOI: https://doi.org/10.1007/978-1-4613-1259-8_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8536-6

  • Online ISBN: 978-1-4613-1259-8

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