Abstract
It has been well established that mitogenic activation produces profound alterations in the migratory behavior of lymphocytes. Activated, blastic T and B cells down-regulate homing receptors which mediate adhesion to the high endothelium of peripheral lymph nodes (1–3). Concurrently, they up-regulate adhesion receptors for extracellular matrix components and for ligands typical of inflammatory endothelium (4–6). The result is a change in traffic patterns, from extravasation into lymph nodes to extravasation into nonlymphoid tissue, especially inflamed tissue (7,8). After the immune response terminates, memory cells, the long-lived residual progeny of the blasts, remain. Memory helper T cells, even when not proliferating, retain the non-homing, inflammation-seeking behavior of the parental blasts (9–11). There are indications that other memory lymphocyte subsets follow similar trends (12,13).
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Ratner, S., Lichlyter, D. (1996). Mitogenic and Non-Mitogenic Induction of Lymphocytic Invasion: Dual Parameter flow Cytometric Analysis. In: Valeriote, F.A., Nakeff, A., Valdivieso, M. (eds) Basic and Clinical Applications of Flow Cytometry. Developments in Oncology, vol 77. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1253-6_4
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DOI: https://doi.org/10.1007/978-1-4613-1253-6_4
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