The Molecular Basis for the Control of Mammalian Cell Growth

  • Gerard I. Evan
Part of the Developments in Oncology book series (DION, volume 77)


Multicellular organisms face a unique problem in regulating proliferation of their component cells. This is because, whereas failure of even a large proportion of cells to divide within a tissue will generally be of little consequence as there are always other cells present that can renew the affected tissue, the unrestrained proliferation of even one cell and its progeny will be lethal. Indeed, this is the disease we call cancer. Recently, there have been many spectacular advances in our understanding of the molecular processes that regulate cell proliferation. This review will outline our current understanding of the major features of cell growth regulation in mammalian cells.


Cell Cycle Human Papilloma Virus Early Growth Response Gene Avian Sarcoma Virus Retinoblastoma Gene Product 
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© Kluwer Academic Publishers 1996

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  • Gerard I. Evan

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