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The Molecular Basis for the Control of Mammalian Cell Growth

  • Gerard I. Evan
Part of the Developments in Oncology book series (DION, volume 77)

Abstract

Multicellular organisms face a unique problem in regulating proliferation of their component cells. This is because, whereas failure of even a large proportion of cells to divide within a tissue will generally be of little consequence as there are always other cells present that can renew the affected tissue, the unrestrained proliferation of even one cell and its progeny will be lethal. Indeed, this is the disease we call cancer. Recently, there have been many spectacular advances in our understanding of the molecular processes that regulate cell proliferation. This review will outline our current understanding of the major features of cell growth regulation in mammalian cells.

Keywords

Cell Cycle Human Papilloma Virus Early Growth Response Gene Avian Sarcoma Virus Retinoblastoma Gene Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Gerard I. Evan

There are no affiliations available

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