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The Clinical Potential of DNA Content Parameters in Human Pediatric and Adult Solid Tumors

  • Chapter
Basic and Clinical Applications of Flow Cytometry

Part of the book series: Developments in Oncology ((DION,volume 77))

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Abstract

The ability to predict the natural history and treatment outcome of human cancers, particularly for an individual patient, has long been a goal of cancer researchers. Knowledge concerning the natural history of a particular cancer was acquired by careful clinical observation long before effective treatments were developed and eventually evolved into our current clinical staging systems. Over the last century, light microscopic and tissue staining technologies have evolved which have allowed the careful correlation of pathological features of tumors and the clinical outcome of the patients that harbor them. Until very recently, individual patient treatment decisions and the design of clinical trials were based primarily on these two types of parameters; clinical stage and histopathology.

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Authors
  1. Mark Zalupski
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  2. John F. Ensley
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Editors and Affiliations

  1. Division of Hematology and Oncology, School of Medicine, Wayne State University, 02188, Detroit, Michigan, 48201, USA

    Frederick A. Valeriote Ph.D. , Alexander Nakeff Ph.D.  & Manuel Valdivieso M.D. ,  & 

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© 1996 Kluwer Academic Publishers

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Zalupski, M., Ensley, J.F. (1996). The Clinical Potential of DNA Content Parameters in Human Pediatric and Adult Solid Tumors. In: Valeriote, F.A., Nakeff, A., Valdivieso, M. (eds) Basic and Clinical Applications of Flow Cytometry. Developments in Oncology, vol 77. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1253-6_11

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  • DOI: https://doi.org/10.1007/978-1-4613-1253-6_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8534-2

  • Online ISBN: 978-1-4613-1253-6

  • eBook Packages: Springer Book Archive

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