The Clinical Potential of DNA Content Parameters in Human Pediatric and Adult Solid Tumors

  • Mark Zalupski
  • John F. Ensley
Part of the Developments in Oncology book series (DION, volume 77)


The ability to predict the natural history and treatment outcome of human cancers, particularly for an individual patient, has long been a goal of cancer researchers. Knowledge concerning the natural history of a particular cancer was acquired by careful clinical observation long before effective treatments were developed and eventually evolved into our current clinical staging systems. Over the last century, light microscopic and tissue staining technologies have evolved which have allowed the careful correlation of pathological features of tumors and the clinical outcome of the patients that harbor them. Until very recently, individual patient treatment decisions and the design of clinical trials were based primarily on these two types of parameters; clinical stage and histopathology.


Homogeneously Staining Region Adult Solid Tumor 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Mark Zalupski
  • John F. Ensley

There are no affiliations available

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