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Vanadium salts stimulate mitogen-activated protein (MAP) kinases and ribosomal S6 kinases

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Vanadium Compounds: Biochemical and Therapeutic Applications

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 16))

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Abstract

Effect of several vanadium salts, sodium ortho vanadate, vanadyl sulfate and sodium meta vanadate on protein tyrosine phosphorylation and serine/threonine kinases in Chinese hamster ovary (CHO) cells overexpressing a normal human insulin receptor was examined. All the compounds stimulated protein tyrosine phosphorylation of two major proteins with molecular masses of 42 kDa (p42) and 44 kDa (p44). The phosphorylation of p42 and p44 was associated with an activation of mitogen activated protein (MAP) kinase as well as increased protein tyrosine phosphorylation of p42mapk and p44mapk. Vanadium salts also activated the 90 kDa ribosomal s6 kinase (p90rsk) and 70 kDa ribosomal s6 kinase (p70s6k). Among the three vanadium salts tested, vanadyl sulfate appeared to be slightly more potent than others in stimulating MAP kinases and p70s6k activity. It is suggested that vanadium-induced activation of MAP kinases and ribosomal s6 kinases may be one of the mechanisms by which insulin like effects of this trace element are mediated.

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Abbreviations

eIF-4:

eukaryotic protein synthesis initiation factor-4

GRB-2:

growth factor receptor bound protein-2

GSK-3:

Glycogen Synthase Kinase-3

1RS-1:

insulin receptor substrate-1

ISPK:

insulin stimulated protein kinase

MAPK:

mitogen activated protein kinase, also known as: ERK — extracellular signal regulated kinase

MAPKK:

mitogen activated protein kinase kinase, also known as —MEK, MAPK or ERK kinase

PHAS-1:

phosphorylated heat and acid stable protein regulated by insulin

PI3K:

phosphatidyl inositol 3-kinase

PP1-G:

protein phosphatase-glycogen bound form

PTK:

protein tyrosine kinase

PTPase:

protein tyrosine phosphatase

rsk:

ribosomal s6 kinases

shc:

src homology domain containing protein

SOS:

son of sevenless

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Authors and Affiliations

  1. Research Group On Diabetes and Metabolic Regulation, Centre de Recherche/Hotel-Dieu de Montreal Hospital, 3850 Saint-Urbain Street, Montreal, Quebec, H2WIT8, Canada

    Sanjay K. Pandey, Jean-Louis Chiasson & Ashok K. Srivastava

  2. Department of Medicine, University of Montreal, Montreal, Quebec, H2WIT8, Canada

    Sanjay K. Pandey, Jean-Louis Chiasson & Ashok K. Srivastava

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  2. Jean-Louis Chiasson
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  1. Centre de Recherche, Hotel-Dieu de Montreal, 3850, rue Saint Urbain, Pavillion Marie de la Ferre, Montreal, Quebec, H2W 1T8, Canada

    Ashok K. Srivastava  & Jean-Louis Chiasson  & 

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Pandey, S.K., Chiasson, JL., Srivastava, A.K. (1995). Vanadium salts stimulate mitogen-activated protein (MAP) kinases and ribosomal S6 kinases. In: Srivastava, A.K., Chiasson, JL. (eds) Vanadium Compounds: Biochemical and Therapeutic Applications. Developments in Molecular and Cellular Biochemistry, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1251-2_8

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