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Regulation and control of glucose overutilization in erythrocytes by vanadate

  • Najma Zaheer Baquer
  • Amit Kumar Saxena
  • Poonam Srivastava
Chapter
Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 16)

Abstract

The insulin mimetic effect of vanadate in in vitro incubation of erythrocytes with high glucose concentrations showed an increase in sorbitol accumulation and glucose utilization using U-14C-glucose. Aldose reductase inhibitors and vanadate addition reversed the sorbitol accumulation, whereas insulin could not reverse it. Increased glucose utilization was also normalized with vanadium compounds. Increased activity of aldose reductase and sorbitol levels in diabetic animals were also normalized with vanadate treatment.

Key words

insulin mimetic vanadate RBC glucose utilization aldose reductase 

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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Najma Zaheer Baquer
    • 1
  • Amit Kumar Saxena
    • 1
  • Poonam Srivastava
    • 1
  1. 1.School of Life SciencesJawaharlal Nehru UniversityNew DelhiIndia

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