Advertisement

Pseudomyxoma peritonei

  • Paul H. Sugarbaker
Part of the Cancer Treatment and Research book series (CTAR, volume 81)

Abstract

Perhaps the major issue confounding our understanding of this disease entity concerns a failure to understand the natural history of pseudomyxoma peritonei. Can one clearly establish a clinical entity called pseudomyxoma peritonei? Is there a fundamental of tumor biology that this disease manifests that distinguishes it clearly from other malignant conditions [1–63]? This author thinks that there is. Pseudomyxoma peritonei is a disease process characterized by a redistribution phenomenon. Redistribution means that large volumes of tumor will be found at some predetermined anatomic sites with the peritoneal cavity but will be absent or in a greatly reduced volume at other sites.

Keywords

Peritoneal Carcinomatosis Cytoreductive Surgery Mucinous Tumor Intraperitoneal Chemotherapy Mucinous Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Woodruff R, McDonald JR. Benign and malignant cystic tumors of the appendix. Surg Gynecol Obstet 1950;71:750–755.Google Scholar
  2. 2.
    Hughes J. Mucocele of the appendix with pseudomyxoma peritonei: A benign or malignant disease? Ann Surg 1967;165:73–76.PubMedCrossRefGoogle Scholar
  3. 3.
    Long RL, Spratt JS, Dowling E. Pseudomyxoma peritonei: New concepts in management with a report of seventeen patients. Am J Surg 1969;117:162–169.PubMedCrossRefGoogle Scholar
  4. 4.
    Little JM, Halliday JP, Glenn DC. Pseudomyxoma peritonei. Lancet 1969;x:659–663.CrossRefGoogle Scholar
  5. 5.
    Aho AJ, Heinonen R, Lauren P. Benign and malignant mucocele of the appendix. Acta Chir Scand 1973;139:392–400.PubMedGoogle Scholar
  6. 6.
    Limber GK, King RE, Silverberg SG. Pseudomyxoma peritonei: A report of ten cases. Ann Surg 1973;178:587–593.PubMedCrossRefGoogle Scholar
  7. 7.
    Gibbs NM. Mucinous cystadenoma and cystadenocarcinoma of the vermiform appendix with particular reference to mucocele and pseudomyxoma peritonei. J Clin Pathol 1973;26:413–421.PubMedCrossRefGoogle Scholar
  8. 8.
    Higa E, Rosai J, Pizzimboni CA, Wise L. Mucosal hyperplasia, mucinous cystadenoma, and mucinous cystadenocarcinoma of the appendix: A re-evaluation of appendiceal ‘mucocele’: Cancer 1973;32:1525–1541.PubMedCrossRefGoogle Scholar
  9. 9.
    Campbell JS, Lou P, Ferguson JP, Krongold I, Kemeny T, Mitton DM, Allan N. Pseudomyxoma peritonei et ovarii with occult neoplasms of appendix. Obstet Gynecol 1973;42:897–902.PubMedGoogle Scholar
  10. 10.
    Qizilbash AH. Mucoceles of the appendix: Their relationship to hyperplastic polyps, mucinous cystadenoma, and cystadenocarcinoma. Arch Pathol 1975;99:548–555.PubMedGoogle Scholar
  11. 11.
    Green N, Gancedo H, Smith R, Bernett G. Pseudomyxoma peritonei—nonoperative management and biochemical findings. Cancer 1975;36:1834–1837.PubMedCrossRefGoogle Scholar
  12. 12.
    Mets T, Van Hove W, Louis H. Pseudomyxoma peritonei: Report of a case with extraperitoneal metastasis and invasion of the spleen. Chest 1977;72:792–794.PubMedCrossRefGoogle Scholar
  13. 13.
    Aranha GV, Reyes CV. Primary epithelial tumors of the appendix and a reappraisal of the appendiceal ‘mucocele’. Dis Colon Rect 1979;22:472–476.CrossRefGoogle Scholar
  14. 14.
    Kahn M, Friedman IR. Mucocele of the appendix: Diagnosis and surgical management. Dis Colon Rectum 1979;22:267–269.PubMedCrossRefGoogle Scholar
  15. 15.
    Fernandez RN, Daly JM. Pseudomyxoma peritonei. Arch Surg 1980;115:409–414.PubMedGoogle Scholar
  16. 16.
    Strutynsky N, Smulewicz JJ. Mucocele of the appendix: Characteristic CT findings. Mount Sinai J Med 1981;48:205–307.Google Scholar
  17. 17.
    Kashani M, Levy M. Primary adenocarcinoma of the appendix with bilateral Krukenberg ovarian tumors. J Surg Oncol 1983;22:101–105.PubMedCrossRefGoogle Scholar
  18. 18.
    Almagro UA. Primary signet-ring carcinoma of the colon. Cancer 1983;52:1453–1457.PubMedCrossRefGoogle Scholar
  19. 19.
    Wackym PH, Gray GF. Tumors of the appendix: I. Neoplastic and nonneoplastic mucoceles. Southern Med J 1984;77:283–287.PubMedCrossRefGoogle Scholar
  20. 20.
    Hanna W, Kahn HJ. The ultrastructure of metastatic adenocarcinoma in serous fluids: An aid in identification of the primary site of the neoplasm. Acta Cytolog 1985;29:202–210.Google Scholar
  21. 21.
    Jones CM III, Homesley HD. Successful treatment of pseudomyxoma peritonei of ovarian origin with cis-platinum, doxorubicin, and cyclophosphamide. Gynecol Oncol 1985;22:257–259.PubMedCrossRefGoogle Scholar
  22. 22.
    Thomas R, Barnhill D, Worsham F, Hoskins W. Krukenberg tumor of the ovary from an occult appendiceal primary: Case report and literature review. Obstet Gynecol 1985;65:95S–98S.PubMedGoogle Scholar
  23. 23.
    Dachman AH, Lichtenstein JE, Friedman AC. Mucocele of the appendix and pseudomyxoma peritonei. AJR 1985;144:923–929.PubMedGoogle Scholar
  24. 24.
    Hirschfield LS, Kahn LB, Winkler B, Bochner RZ, Gibstein AA. Adenocarcinoid of the appendix presenting as bilateral Krukenberg’s tumor of the ovaries. Arch Pathol Lab Med 1985;109:930–933.PubMedGoogle Scholar
  25. 25.
    Miller DL, Udelsman R, Sugarbaker PH. Calcification of pseudomyxoma peritonei following intraperitoneal chemotherapy: CT demonstration. J Comput Assist Tomogr 1985;9:1123–1124.PubMedCrossRefGoogle Scholar
  26. 26.
    Skaane P, Sauer T, Jerve F. Mucinous adenocarcinoma of the appendix presenting as an ovarian cystadenocarcinoma: Case report and review of appendiceal neoplasms with ovarian metastases. Eur J Surg Oncol 1986;12:379–384.PubMedGoogle Scholar
  27. 27.
    Jurgeleit HC. Pseudomyxoma peritonei: A localized, benign variant of appendiceal origin. Dis Colon Rectum 1986;29:469–470.PubMedCrossRefGoogle Scholar
  28. 28.
    Sugarbaker PH, Kern K, Lack E. Malignant pseudomyxoma of colonic origin. Natural history and presentation of a curative approach to treatment. Dis Colon Rectum 1987;30:772–779.PubMedCrossRefGoogle Scholar
  29. 29.
    Sugarbaker PH. Curative treatment of peritoneal carcinomatosis from grade I mucinous adenocarcinoma. Surg Rounds 1988;11:45–63.Google Scholar
  30. 30.
    Hughes KS, Miller DL, Neuman R, Sugarbaker PH. Extrahepatic tumor deposits misdiagnosed as intrahepatic metastases. Arch Surg 1988;123:1013–1015.PubMedGoogle Scholar
  31. 31.
    Sugarbaker PH. Management of peritoneal carcinomatosis. Prog Reg Cancer Ther, Acta Med Austriaca 1989;3/4:57–60.Google Scholar
  32. 32.
    Sugarbaker PH. Cancer of the appendix and pseudomyxoma peritonei. In Fazio VW, ed Current Therapy in Colon and Rectal Surgery. Philadelphia: BC Decker, 1989, pp 295–301.Google Scholar
  33. 33.
    Sugarbaker PH. Surgical treatment of peritoneal carcinomatosis. Cana J Surg 1989;32:164–170.Google Scholar
  34. 34.
    Cunliffe WJ, Sugarbaker PH. Gastrointestinal malignancy: Rationale for adjuvant therapy using early postoperative intraperitoneal chemotherapy (EPIC). Br J Surg 1989;76:1082–1090.PubMedCrossRefGoogle Scholar
  35. 35.
    Sugarbaker PH, Cunliffe W, Belliveau JF, deBruijn EA, Graves T, Mullins R, Schlag P, Gianola F. Rationale for perioperative intraperitoneal chemotherapy as a surgical adjuvant for gastrointestinal malignancy. Reg Cancer Treat 1988;1:66–79.Google Scholar
  36. 36.
    Sugarbaker PH. Surgical management of peritoneal carcinosis: Diagnosis, prevention, and treatment. Langenbecks Arch Chir 1988;373:189–196.PubMedCrossRefGoogle Scholar
  37. 37.
    Sugarbaker PH, Cunliffe WJ, Belliveau JF, deBruijn EA, Graves T, Mullins RE, Schlag P. Rationale for integrating early postoperative intraperitoneal chemotherapy (EPIC) into the surgical treatment of gastrointestinal cancer. Semin Oncol 1989;16:83–97.PubMedGoogle Scholar
  38. 38.
    Sugarbaker PH, Graves T, deBruijn EA, Cunliffe WJ, Mullins RE, Hull WE, Oliff L, Schlag P. Rationale for early postoperative intraperitoneal chemotherapy (EPIC) in patients with advanced gastrointestinal cancer. Cancer Res 1990;50:5790–5794.PubMedGoogle Scholar
  39. 39.
    Hallisey MJ, Vercillo AP, Daoud I, Becker DR. Pseudomyxoma peritonei of appendiceal origin. Contem Surg 1990;36:61–64.Google Scholar
  40. 40.
    Sugarbaker PH. Cytoreductive surgery and intraperitoneal chemotherapy with peritoneal spread of cystadenocarcinoma. Eur J Surg Suppl 1991;561:75–82.PubMedGoogle Scholar
  41. 41.
    Sugarbaker PH, Landy D, Pascal R. Intraperitoneal chemotherapy for peritoneal carcinomatosis from colonic or appendicial cystadenocarcinoma: Rationale and results of treatment. In Ragaz J, ed Effects of Therapy on Biology and Kinetics of Surviving Tumor. New York: Alan R. Liss, 1991, pp xxx–xxx.Google Scholar
  42. 42.
    Vidal-Jove J, Steves MA, Banec G, Litwin FP, Sugarbaker, PH. Curative approach to pseudomyxoma peritonei. Contemp Surg 1991;538:13–21.Google Scholar
  43. 43.
    Sugarbaker PH. Peritoneal carcinomatosis from large bowel and appendical cancer: A new approach to treatment. Postgrad Adv Colorect Surg 1991;11-X:1–14.Google Scholar
  44. 44.
    Sugarbaker PH. Surgical treatment of pseudomyxoma peritonei. In, eds, Proceedings of the III Congress on Neoadjuvant Therapy. Springer-Verlag, 1991, pp xxx–xxx, in press.Google Scholar
  45. 45.
    Sugarbaker PH. Surgical management of peritoneal carcinomatosis. In Najarían JS, Delaney JP, eds Progress in Cancer Surgery. St. Louis, MO, Mosby Year Book, 1991, pp xxx–xxx.Google Scholar
  46. 46.
    Young RH, Gilks CB, Scully RE. Mucinous tumors of the appendix associated with mucinous tumors of the ovary and pseudomyxoma peritonei. Am J Surg Pathol 1991;15:415–429.PubMedCrossRefGoogle Scholar
  47. 47.
    Smith JW, Kemeny N, Caldwell C, et al. Pseudomyxoma peritonei of appendiceal origin. Cancer 1992;70:386–401.CrossRefGoogle Scholar
  48. 48.
    Huff T, Brand E. Pseudomyxoma peritonei: Treatment with the argon beam coagulator. Obstet Gynecol 1992;80:569–571.PubMedGoogle Scholar
  49. 49.
    Landen S, Bertrand C, Maddern GJ, Herman D, Pourbaix A, Neve A, Schmitz A. Appendiceal mucoceles and pseudomyxoma peritonei. Surg Gynecol Obstet 1992;175:401–404.PubMedGoogle Scholar
  50. 50.
    Sugarbaker PH, Steves MA, Hafner GH. Treatment of peritoneal carcinomatosis from colon or appendiceal cancer with induction intraperitoneal chemotherapy. Reg Cancer Treat 1993;4:183–187.Google Scholar
  51. 51.
    Sugarbaker PH. Intraperitoneal chemotherapy in the management of colorectal & appendiceal malignancy. J Infusional Ther 1993;3:53–59.Google Scholar
  52. 52.
    Sugarbaker PH. Peritoneal carcinomatosis. In Wanebo H, ed Colorectal Cancer. St. Louis, MO: Mosby Year Book, 1993, pp 428–436.Google Scholar
  53. 53.
    Sugarbaker PH, Bowei Z, Banez Sese G, Shmookler B. Peritoneal carcinomatosis from appendiceal cancer: Results in 69 patients treated by cytoreductive surgery and intraperitoneal chemotherapy. Dis Colon Rectum 1993;36:323–329.PubMedCrossRefGoogle Scholar
  54. 54.
    Sugarbaker PH. Intraperitoneal Chemotherapy and Cytoreductive Surgery: A Manual for Physicians and Nurses. Grand Rapids, MI: Ludann, 1993.Google Scholar
  55. 55.
    Fann JI, Vierra M, Fisher D, Oberhelman HA, Cobb L. Pseudomyxoma peritonei. Surg Gynecol Obstet 1993;177:441–447.PubMedGoogle Scholar
  56. 56.
    Nitecki SS, Wolff BG, Schlinkert R, Sarr MG. The natural history of surgically treated primary adenocarcinoma of the appendix. Ann Surg 1994;29:51–57.CrossRefGoogle Scholar
  57. 57.
    Jacquet P, Vidal-Jove J, Zhu BW, Sugarbaker PH. Peritoneal carcinomatosis from intraabdominal malignancy: Natural history and new prospects for management. Acta Belg Chir 1994;94:191–197.Google Scholar
  58. 58.
    Sugarbaker PH. Pseudomyxoma peritonei: A cancer whose biology is characterized by a redistribution phenomenon (editorial). Ann Surg 1994;219:109–111.PubMedCrossRefGoogle Scholar
  59. 59.
    Fernandez-Trigo V, Sugarbaker PH, Fallah S. Treatment failures after cytoreductive surgery and intraperitoneal chemotherapy in patients with pseudomyxoma. Acta Chir Austriaca, in press.Google Scholar
  60. 60.
    Sugarbaker PH. Intraperitoneal chemotherapy for treatment and prevention of peritoneal carcinomatosis and Sarcomatosis. Dis Colon Rectum 1994;37:S115–S121.PubMedCrossRefGoogle Scholar
  61. 61.
    Gough DB, Donohue JH, Schutt AJ, Gonchoroff N, Goellner JR, Wilson TO, Naessens JM, O’Brien PC, van Hereden JA. Pseudomyxoma peritonei: Long-term patient survival with an aggressive regional approach. Ann Surg 1994;219:112–119.PubMedCrossRefGoogle Scholar
  62. 62.
    Sugarbaker PH, Jablonski KA. Prognostic features of 51 colorectal and 130 appendiceal cancer patients with peritoneal carcinomatosis treated by cytoreductive surgery and intraperitoneal chemotherapy. Ann Surg 1995;221:124–132.PubMedCrossRefGoogle Scholar
  63. 63.
    Jacquet P, Jelenich J, Sugarbaker PH. Evaluation of computed tomography in patients with peritoneal carcinomatosis. Cancer 1994;72:1631–1636.CrossRefGoogle Scholar
  64. 64.
    Albelda SM, Buck CA. Integrins and other cell adhesion molecules. FASEB J 1990;4:2868–2880.PubMedGoogle Scholar
  65. 65.
    Feldman GB, Knapp RI. Lymphatic drainage of the peritoneal cavity and significance in ovarian cancer. Am J Obstet Gynecol 1974;119:991–994.PubMedGoogle Scholar
  66. 66.
    Hagiwara A, Takahashi T, Sawai K, Taniguchi H, Shimotsuma M, Okano S, Sakakura C, Tsujimoto H, Osaki K, Sasaki S, Shirasu M. Milky spots as the implantation site for malignant cells in peritoneal dissemination in mice. Cancer Res 1993;53:687–692.PubMedGoogle Scholar
  67. 67.
    Ronnett BM, Kurman RJ, Zahn CM, Shmookler BM, Jablonski KA, Kass ME, Sugarbaker PH. Pseudomyxoma peritonei in women: A clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumors of low malignant potential. Human Path 1995;26:509–524.CrossRefGoogle Scholar
  68. 68.
    Spencer RF, Livingstone PD. Unusual combined pathology in a femoral hernia. Clin Notes 1984;29:225–256.Google Scholar
  69. 69.
    Miller RT, Sarikaya H, Jenison EL. Adenocarcinoid tumor of appendix presenting as unilateral Krukenberg tumor. J Surg Oncol 1988;37:65–71.PubMedCrossRefGoogle Scholar
  70. 70.
    Deture FA, Madorsky ML, Deardourff SL. Adenocarcinoma of the appendix—A rare cause of right ureteral obstruction. J Urol 1976;116:514–515.PubMedGoogle Scholar
  71. 71.
    Bartholomew LG, Farrow GM, DeWeerd JH. Adenocarcinoma of the appendix simulating primary bladder carcinoma. Dig Dis Sci 1984;29:371–375.PubMedCrossRefGoogle Scholar
  72. 72.
    Skaane P, Isachsen MM, Hoiseth A. Computed tomography of mucin-producing adenocarcinoma of the appendix presenting as a bladder tumor. J Comput Assist Tomogr 1985;9:566–567.PubMedCrossRefGoogle Scholar
  73. 73.
    Dalton DP, Dalkin BL, Sener SF, Pappas PS, Blum MD. Enterovesical fistula secondary to mucinous adenocarcinoma of appendix. J Urol 1987;138:617–618.PubMedGoogle Scholar
  74. 74.
    Sugarbaker PH. Dissection by electrocautery with a ball tip. J Surg Oncol 1994;56:246–248.PubMedCrossRefGoogle Scholar
  75. 75.
    Sugarbaker PH. Peritonectomy procedures. Ann Surg 1995;221:29–42.PubMedCrossRefGoogle Scholar
  76. 76.
    Makela J, Haukipuro K, Laitnen S, Kairaluoma MI. Palliative operations for colorectal cancer. Dis Colon Rectum 1990;33:846–850.PubMedCrossRefGoogle Scholar
  77. 77.
    Moreno E, Sugarbaker PH. Gastrointestinal fistula following cytoreductive procedures for peritoneal carcinomatosis: Incidence and outcome. J Exp Clin Cancer Res 1993;12:153–158.Google Scholar
  78. 78.
    Fernandez-Trigo V, Sugarbaker PH. Diagnosis and Management of postoperative gastrointestinal fistula: A kinetic analysis. J Exp Clin Cancer Res 1994;13:233–241.Google Scholar
  79. 79.
    Brodsky JT, Cohen AM. Peritoneal seeding following potentially curative resection of colonic carcinoma: Implications for adjuvant therapy. Dis Colon Rectum 1991;34:723–727.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1996

Authors and Affiliations

  • Paul H. Sugarbaker

There are no affiliations available

Personalised recommendations