Abstract
Mitochondrial DNA mutations in the myocardium have been reported in patients with idiopathic cardiomyopathy [1–3], and such mutations are thought to be one of several possible causes of cardiomyopathy. It has also been reported that these mutations can be acquired under the influence of free radicals and other factors with increasing age [4–6]. In the present study, myocardial mitochondrial DNA mutations were investigated using autopsy materials from diabetic patients as well as patients with other diseases, since diabetes mellitus is one of a number of diseases in which free radicals cause damage to various organs. The data presented in this article include some published previously [7] and additional new data.
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Takeda, N., Tanamura, A., Iwai, T., Hayashi, Y., Nomura, S. (1995). Mutations of Myocardial Mitochondrial DNA in Diabetic Patients. In: Dhalla, N.S., Pierce, G.N., Panagia, V., Beamish, R.E. (eds) Heart Hypertrophy and Failure. Developments in Cardiovascular Medicine, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1237-6_5
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DOI: https://doi.org/10.1007/978-1-4613-1237-6_5
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