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The Alteration of Signal Transduction System in Heart Failure: Renin-Angiotensin System in Diseased Human Heart

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Heart Hypertrophy and Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 169))

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Abstract

Recently, it has been reported that the signal through the (β-adrenergic signal transduction system in failing heart is reduced. This includes the reduction of (β-adrenergic receptors and Gs-protein, decreased adenylyl activity, and increased Gl-protein (Figure 1). But it is still not clear whether the signal through α-adrenergic receptor changes in failing hearts. From this point of view, we attempted to determine the signal transduction systems in cardiomyopathy using cardiomyopathic hamster hearts. Syrian cardiomyo-pathic hamsters (BIO 14.6 and BIO 53.58) display hereditary abnormalities of the cardiac and skeletal muscles that are inherited as an autosomal recessive trait [1] BIO 14.6 cardiac involvement results in initial myocardial hypertrophy that is followed by cardiac dilatation and death due to congestive heart failure [2]. It is thought that the cardiomyopathic hamster provides a useful model for studying human cardiac diseases, such as hypertrophic cardiomyopathy [3,4].

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Authors
  1. Hideaki Kawaguchi
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  2. Akira Kitabatake
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Editors and Affiliations

  1. MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, 351 Taché Avenue, Winnipeg, Manitoba, R2H 2A6, Canada

    Naranjan S. Dhalla (Distinguished Professor), Grant N. Pierce (Professor), Vincenzo Panagia (Professor) & Robert E. Beamish (Professor Emeritus) (Distinguished Professor),  (Professor),  (Professor) &  (Professor Emeritus)

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© 1995 Kluwer Academic Publishers

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Kawaguchi, H., Kitabatake, A. (1995). The Alteration of Signal Transduction System in Heart Failure: Renin-Angiotensin System in Diseased Human Heart. In: Dhalla, N.S., Pierce, G.N., Panagia, V., Beamish, R.E. (eds) Heart Hypertrophy and Failure. Developments in Cardiovascular Medicine, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1237-6_33

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  • DOI: https://doi.org/10.1007/978-1-4613-1237-6_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8526-7

  • Online ISBN: 978-1-4613-1237-6

  • eBook Packages: Springer Book Archive

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