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Heart Hypertrophy and Failure pp 447–462Cite as

Role of Protein Kinase C in the Development of Non-Insulin-Dependent Diabetic Cardiomyopathy

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 169))

Abstract

Diabetes is an important risk factor in the development of congestive heart failure [1]. While the link between diabetes and heart failure originally was attributed solely to accelerated coronary artery disease and hypertension, it is now apparent that diabetes-mediated impairment of heart function also is a significant causative factor. Epidemiological studies have shown that diabetic patients without evidence of atherosclerotic, valvular, congenital, hypertensive, or alcoholic heart disease suffer a higher incidence of congestive heart failure [1]. Moreover, it is widely recognized that clinically apparent diastolic and systolic dysfunction are common complications of diabetes [2–7]. These findings have revealed the clinical relevance of cardiac muscle disease in diabetics and have stimulated interest in the further study of these abnormalities.

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Authors
  1. Stephen Schaffer
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  2. Cherry Ballard
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  3. Arin Bhattacharjee
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Editor information

Editors and Affiliations

  1. MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, 351 Taché Avenue, Winnipeg, Manitoba, R2H 2A6, Canada

    Naranjan S. Dhalla (Distinguished Professor), Grant N. Pierce (Professor), Vincenzo Panagia (Professor) & Robert E. Beamish (Professor Emeritus) (Distinguished Professor),  (Professor),  (Professor) &  (Professor Emeritus)

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© 1995 Kluwer Academic Publishers

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Schaffer, S., Ballard, C., Bhattacharjee, A. (1995). Role of Protein Kinase C in the Development of Non-Insulin-Dependent Diabetic Cardiomyopathy. In: Dhalla, N.S., Pierce, G.N., Panagia, V., Beamish, R.E. (eds) Heart Hypertrophy and Failure. Developments in Cardiovascular Medicine, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1237-6_32

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  • DOI: https://doi.org/10.1007/978-1-4613-1237-6_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8526-7

  • Online ISBN: 978-1-4613-1237-6

  • eBook Packages: Springer Book Archive

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