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Significance of Adrenergic Stimuli for Cardiac Remodeling under Chronic Overload: Relative Importance of Myocardial Factors versus Ventricular Geometry in Cardiac Failure

  • Chapter
Heart Hypertrophy and Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 169))

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Abstract

It is generally accepted that, in addition to mechanical factors, humoral actions play a role in the regulation of cardiac myocyte growth. The catecholamines were particularly regarded as “hypertrophy hormones” by some authors [1–12]. Furthermore, the sympathetic nervous system seems to play a role in the pathogenesis of congestive heart failure. Activation of this system with elevated plasma catecholamine level and corresponding consequences for peripheral resistance, cardiac energetics, and adrenergic receptor density is a universal response to impaired cardiac function [13–16]. A direct relation between plasma catecholamine level and mortality in patients with chronic congestive cardiac failure has been demonstrated [3,16]. There seems to be general agreement that the application of full β-agonists, while providing acute hemodynamic improvement, has serious adverse effects in long-term use. With regard to β-adrenergic receptor blockade, beneficial as well as detrimental effects have been reported [17–22].

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Authors
  1. Marian Brändle
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  2. Bernhard Dierberger
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  3. Gerhard Mall
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  4. Ruthard Jacob
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Editors and Affiliations

  1. MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, 351 Taché Avenue, Winnipeg, Manitoba, R2H 2A6, Canada

    Naranjan S. Dhalla (Distinguished Professor), Grant N. Pierce (Professor), Vincenzo Panagia (Professor) & Robert E. Beamish (Professor Emeritus) (Distinguished Professor),  (Professor),  (Professor) &  (Professor Emeritus)

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© 1995 Kluwer Academic Publishers

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Brändle, M., Dierberger, B., Mall, G., Jacob, R. (1995). Significance of Adrenergic Stimuli for Cardiac Remodeling under Chronic Overload: Relative Importance of Myocardial Factors versus Ventricular Geometry in Cardiac Failure. In: Dhalla, N.S., Pierce, G.N., Panagia, V., Beamish, R.E. (eds) Heart Hypertrophy and Failure. Developments in Cardiovascular Medicine, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1237-6_29

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  • DOI: https://doi.org/10.1007/978-1-4613-1237-6_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8526-7

  • Online ISBN: 978-1-4613-1237-6

  • eBook Packages: Springer Book Archive

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