Cardiac Hypertrophy and the Renin-Angiotensin System
The heart responds to the increased afterload of systemic hypertension by developing left ventricular hypertrophy to increase its contractile force and maintain normal cardiac function. This scries of events is not precipitated solely by the mechanical stress imposed by hypertension, but also by activation of the endogenous renin-angiotensin system in cardiac tissue. The development of cardiac hypertrophy as an adaptation phenomenon is associated with disturbed diastolic function in the early stages and may lead to a significant increase in concurrent ischemic heart disease, and even to sudden death. Thus, cardiac hypertrophy has recently attracted attention as an important factor influencing the prognosis for patients with hypertension.
KeywordsIschemia Tyrosine Angiotensin Phenylalanine Threonine
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