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Cardiac Remodeling by Alterations in Phospholamban Protein Levels

  • Chapter
Heart Hypertrophy and Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 169))

Abstract

Heart failure is a low cardiac output syndrome characterized by both systolic and diastolic dysfunction. Hallmarks of cardiac failure include marked ventricular hypertrophy or dilation, decreased velocity of contraction, decreased rate of relaxation, and abnormal cytosolic calcium handling. Alterations in these parameters can be explained by alterations in cardiac sarcoplasmic reticulum (SR) function. The cardiac SR plays a critical role in cardiac excitation-contraction coupling by regulating the rate of myocardial relaxation, which is the rate-limiting step in the cardiac contraction/relaxation cycle [1,2]. The rate and extent of myocardial relaxation is determined by the rate and extent of Ca2+ uptake from the myoplasm into the SR. Thus, the SR functions as the primary regulator of myocardial intracellular Ca2+ levels.

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Authors
  1. Wusheng Luo
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  2. Eva Kiss
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  3. Kimberly L. Koss
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  4. Ingrid L. Grupp
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  5. Judy M. Harrer
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  6. W. Keith Jones
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  7. Istvan Edes
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  8. Evangelia G. Kranias
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Editors and Affiliations

  1. MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, 351 Taché Avenue, Winnipeg, Manitoba, R2H 2A6, Canada

    Naranjan S. Dhalla (Distinguished Professor), Grant N. Pierce (Professor), Vincenzo Panagia (Professor) & Robert E. Beamish (Professor Emeritus) (Distinguished Professor),  (Professor),  (Professor) &  (Professor Emeritus)

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© 1995 Kluwer Academic Publishers

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Luo, W. et al. (1995). Cardiac Remodeling by Alterations in Phospholamban Protein Levels. In: Dhalla, N.S., Pierce, G.N., Panagia, V., Beamish, R.E. (eds) Heart Hypertrophy and Failure. Developments in Cardiovascular Medicine, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1237-6_10

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  • DOI: https://doi.org/10.1007/978-1-4613-1237-6_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8526-7

  • Online ISBN: 978-1-4613-1237-6

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