Skip to main content
SpringerLink
Log in

Interventions in Experimentally Induced Diabetic Cardiomyopathy

  • Chapter
Book cover Pathophysiology of Heart Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 168))

  • 163 Accesses

Abstract

Numerous clinical and epidemiological reports have confirmed that human diabetics appear particularly susceptible to heart disease, which is a leading cause of death in these patients [1,2]. The cardiac problems include a lower stroke volume, cardiac index, and ejection fraction and a higher left ventricular end-diastolic pressure [3–5]. Factors that appear to largely account for this increased incidence of cardiovascular dysfunction during diabetes include large (macroangiopathy) and small (microangiopathy) vessel disease and autonomic neuropathy [6]. However, it has also become apparent that these factors are not always responsible for the cardiac problems associated with diabetes. For example, a significant number of diabetic patients who do not develop atherosclerosis and autonomic neuropathy still suffer from cardiomegaly, left ventricular dysfunction, and clinically overt congestive heart failure [7]. These results suggest that a specific cardiac muscle disease may also occur during diabetes [8,9] (diabetic cardiomyopathy) and that this disease is probably a consequence of a direct effect of insulin deficiency on myocardial cell function.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kannel WB, McGee DL. 1979. Diabetes and cardiovascular disease: the Framingham Study. JAMA 241:2035–2038.

    Article  PubMed  CAS  Google Scholar 

  2. Palumbo PJ, Elveback CR, Conolly DC. 1981. Coronary artery disease and congestive heart failure in the diabetic: epidemiological aspects. The Rochester Diabetes Project. In Scott RC (ed.), Clinical Cardiology and Diabetes. Futura: New York, p. 13.

    Google Scholar 

  3. Hamby RI, Zoneraich S, Sherman L. 1974. Diabetic cardiomyopathy. JAMA 229:1749–1754.

    Article  PubMed  CAS  Google Scholar 

  4. Regan TJ, Lyons MM, Ahmed SS. 1977. Evidence for cardiomyopathy in familial diabetes mellitus. J Clin Invest 60:885–889.

    Article  Google Scholar 

  5. D’Elia JA, Weinrauch LA, Healy RW, Libertino RW, Bradley RF, Leland OS. 1979. Myocardial dysfunction without coronary artery disease in diabetic renal failure. Am J Cardiol 43:193–199.

    Article  PubMed  Google Scholar 

  6. Ledet B, Neubauer B, Christensen NJ, Lundback K. 1979. Diabetic cardiopathy. Diabetologia 16:207–209.

    Article  PubMed  CAS  Google Scholar 

  7. Ahmed SS, Jaferi G A, Narang RM, Regan TJ. 1975. Preclinical abnormality of left ventricular function in diabetes mellitus. Am Heart J 90:153–158.

    Article  Google Scholar 

  8. Fein FS, Sonnenblick EH. 1985. Diabetic cardiomyopathy. Prog Cardiovasc Res 27:255–270.

    Article  CAS  Google Scholar 

  9. Galderisi M, Anderson KM, Wilson PWF, Levy D. 1991. Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (The Framingham Heart Study). Am J Cardiol 68:85–89.

    Article  PubMed  CAS  Google Scholar 

  10. Regan TJ, Ettinger PO, Khan MI, Jesran MU, Lyons MM, Oldewurtel HA, Weber M. 1974. Altered myocardial function and metabolism in chronic diabetes mellitus without ischemia in dogs. Circ Res 35:222–237.

    CAS  Google Scholar 

  11. Miller TB Jr. 1979. Cardiac performance of isolated perfused hearts from alloxan diabetic rats. Am J Physiol 236:808–812.

    Google Scholar 

  12. Vadllamudi RVSV, Rodgers RL, McNeill JH. 1982. The effect of chronic alloxan- and streptozotocin-induced diabetes on isolated rat heart performance. Can J Physiol Pharmacol 60:902–911.

    Article  Google Scholar 

  13. Fein FS, Kornstein LB, Strobeck JE, Capasso JM, Sonnenblick EH. 1980. Altered myocardial mechanics in diabetic rats. Circ Res 47:922–933.

    PubMed  CAS  Google Scholar 

  14. Rodrigues B, McNeill JH. 1986. Cardiac function in spontaneously hypertensive diabetic rats. Am J Physiol 251:571–580.

    Google Scholar 

  15. National Diabetes Data Group. 1979. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039–1057.

    Google Scholar 

  16. Marliss EB, Nakhooda AF, Poussier P, Sima AAF. 1982. The diabetic syndrome of the “BB” Wistar rat: possible relevance to Type 1 (insulin-dependent) diabetes in man. Diabetologia 22:225–232.

    Article  PubMed  CAS  Google Scholar 

  17. Rodrigues B, McNeill JH. 1990. Cardiac dysfunction in isolated perfused hearts from spontaneously diabetic BB rats. Can J Physiol Pharmacol 68:514–518.

    Article  PubMed  CAS  Google Scholar 

  18. Rodrigues B, McNeill JH. 1992. The diabetic heart: metabolic causes for the development of a cardiomyopathy. Cardiovas Res 26:913–922.

    Article  CAS  Google Scholar 

  19. Jackson CV, McGarth GM, Tahiliani AG, Vadlamudi RVSV, McNeill JH. 1985. A functional and ultrastructural analysis of experimental diabetic rat myocardium: manifestation of cardiomyopathy. Diabetes 34:876–883.

    Article  PubMed  CAS  Google Scholar 

  20. Rodrigues B, Cam MC, McNeill JH. In press. Myocardial substrate metabolism: Implications for diabetic cardiomyopathy. J Mol Cell Cardiol.

    Google Scholar 

  21. Chattopadhyay J, Thompson EW, Schmid HHO. 1990. Elevated levels of non-esterified fatty acids in the myocardium of alloxan diabetic rats. Lipids 25:307–310.

    Article  PubMed  CAS  Google Scholar 

  22. Opie LH. 1970. Effect of fatty acid on contractility and rhythm of the heart. Nature 227:1055–1056.

    Article  PubMed  CAS  Google Scholar 

  23. Garvey WG, Hardin G, Juhaszova M, Dominguez JH. 1993. Effects of diabetes on myocardial glucose transport system in rats: implication for diabetic cardiomyopathy. Am J Physiol 264:837–844.

    Google Scholar 

  24. Randle PJ, Hales CN, Garland PB, Newsholme EA. 1963. The glucose fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785–789.

    Article  PubMed  CAS  Google Scholar 

  25. Kerby AK, Vary TC, Randle PJ. 1985. Molecular mechanisms regulating myocardial glucose oxidation. Basic Res Cardiol 80(Suppl 2):93–96.

    Google Scholar 

  26. Wall SR, Lopaschuk GD. 1989. Glucose oxidation rates in fatty acid perfused isolated working hearts from diabetic rats. Biochim Biophys Acta 1006:97–103.

    PubMed  CAS  Google Scholar 

  27. Chen V, lanuzzo CD, Fong BC, Spitzer JJ. 1984. The effects of acute and chronic diabetes on myocardial metabolism in rats. Diabetes 33:1078–1084.

    Article  PubMed  CAS  Google Scholar 

  28. Vadlamudi RVSV, Rodgers RL, McNeill JH. 1982. The effect of chronic alloxan- and streptozotocin-induced diabetes on isolated rat heart performance. Can J Physiol Pharmacol 60:902–911.

    Article  PubMed  CAS  Google Scholar 

  29. McGarth GM, McNeill JH. 1986. Cardiac ultrastructural changes in streptozotocin-induced diabetic rats: effects of insulin treatment. Can J Cardiol 2:164–169.

    Google Scholar 

  30. Heyliger CE, Rodrigues B, McNeill JH. 1989. Alterations of cardiac muscle membranes in hypertension and diabetes mellitus. In Kwan CY (ed.), Membrane Abnormalities in Hypertension and Diabetes Mellitus. CRC Press: Boca Raton, FL, pp. 91–116.

    Google Scholar 

  31. Lopaschuk GD, Eibschutz B, Katz S, McNeill JH. 1984. Depression of calcium transport in sarcoplasmic reticulum from diabetic rats: lack of involvement by specific regulatory mediators. Gen Pharmacol 15:1–5.

    Article  PubMed  CAS  Google Scholar 

  32. Lopaschuk GD, Katz S, McNeill JH. 1983. The effect of alloxan- and streptozotocin-induced diabetes on calcium transport in rat cardiac sarcoplasmic reticulum. The possible involvement of long chain acylcarnitines. Can J Physiol Pharmacol 61:439–448.

    Article  PubMed  CAS  Google Scholar 

  33. Yu Z, Tibbits GF, McNeill JH. 1994. Cellular function of diabetic cardiomyocytes: contractility, rapid cooling contracture, and ryanodine binding. Am J Physiol 266:2082–2089.

    Google Scholar 

  34. McNeill JH, Tahiliani AG. 1986. Diabetes-induced cardiac changes. Trends Pharmacol Sci 7:364–367.

    Article  CAS  Google Scholar 

  35. Tolman EL, Barris E, Burns M, Prasini A, Partridge R. 1979. Effects of vanadium on glucose metabolism in vitro. Life Sci 25:1159–1164.

    Article  PubMed  CAS  Google Scholar 

  36. Tamura S, Brown TA, Dubler RE, Larner J. 1983. Insulin-like effect of vanadate on adipocyte glycogen synthase and on phosphorylation of 95,000 dalton subunit of insulin receptor. Biochem Biophys Res Commun 113:80–86.

    Article  PubMed  CAS  Google Scholar 

  37. Heyliger CE, Tahiliani AG, McNeill JH. 1985. Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Science 227:1474–1477.

    Article  PubMed  CAS  Google Scholar 

  38. Takada K, Temma K, Akera T. 1982. Inotropic effects of vanadate in isolated rat and guinea-pig heart under conditions which modify calcium pools involved in contractile activation. J Pharmacol Exp Ther 222:132–139.

    Google Scholar 

  39. Ramanadham S, Mongold JJ, Brownsey RW, Cros GH, McNeill JH. 1989. Oral vanadyl sulfate in treatment of diabetes mellitus in rats. Am J Physiol 257:904–911.

    Google Scholar 

  40. Ramanadham S, Brownsey RW, Cros GH, Mongold JJ, McNeill JH. 1989. Sustained prevention of myocardial and metabolic abnormalities in diabetic rats following withdrawal from oral vanadyl treatment. Metabolism 38:1022–1028.

    Article  PubMed  CAS  Google Scholar 

  41. Pederson RA, Ramanadham S, Buchan AMJ, McNeill JH. 1989. Long-term effects of vanadyl treatment on streptozocin-induced diabetes in rats. Diabetes 38:1390–1393.

    Article  PubMed  CAS  Google Scholar 

  42. Battell ML, Yuen VG, McNeill JH. 1992. Treatment of BB rats with vanadyl sulphate. Pharmacol Commun 1:291–301.

    CAS  Google Scholar 

  43. Underwood EJ. 1977. Vanadium. In Trace Elements in Human and Animal Nutrition. Academic Press: New York, pp. 388–397.

    Google Scholar 

  44. Cam MC, Cros GH, Serrano JJ, Lazaro R, McNeill JH. 1993. In vivo antidiabetic actions of naglivan, an organic compound in streptozotocin-induced diabetes. Diabetes Res Clin Pract 20:11–121.

    Article  Google Scholar 

  45. McNeill JH, Yuen VG, Hoveyda HR, Orvig C. 1992. Bis(maltolato)oxovanadium(IV) is a potent insulin mimic. J Med Chem 35:1489–1491.

    Article  PubMed  CAS  Google Scholar 

  46. Ramanadham S, Cros GH, Mongold JJ, Serrano JJ, McNeill JH. 1990. Enhanced in vivo sensitivity of vanadyl-treated diabetic rats to insulin. Can J Physiol Pharmacol 68:486–491.

    Article  PubMed  CAS  Google Scholar 

  47. Yuen VG, Orvig C, Thompson KH, McNeill JH. 1992. Improvement in cardiac dysfunction in streptozotocin-induced diabetic rats following chronic oral administration of bis(maltolato)oxovanadium(IV). Can J Physiol Pharmacol 71:270–276.

    Article  Google Scholar 

  48. Yuen VG, Orvig C, McNeill JH. Submitted. Comparison of the glucose lowering properties vanadyl sulfate and bis(maltolato)oxovanadium(IV) following acute and chronic administration.

    Google Scholar 

  49. Ezaki O. 1990. The insulin-like effects of selenate in rat adipocytes. J Biol Chem 265: 1124–1128.

    PubMed  CAS  Google Scholar 

  50. McNeill JH, Delgatty HLM, Battell ML. 1991. Insulinlike effects of sodium selenate in streptozotocin-induced diabetic rats. Diabetes 40:1675–1678.

    Article  PubMed  CAS  Google Scholar 

  51. Rodrigues B, Xiang H, McNeill JH. 1988. Effect of L-carnitine treatment on lipid metabolism and cardiac performancein chronically diabetic rats. Diabetes 37:1358–1364.

    Article  PubMed  CAS  Google Scholar 

  52. Heyliger CE, Rodrigues B, McNeill JH. 1986. Effect of choline and methionine treatment on cardiac dysfunction of diabetic rats. Diabetes 35:1152–1157.

    Article  PubMed  CAS  Google Scholar 

  53. Rodrigues B, Goyal RK, McNeill JH. 1986. Effects of hydralazine on streptozotocin-induced diabetic rats: prevention of hyperlipidemia and improvement in cardiac function. J Pharmacol Exp Ther 237:292–299.

    PubMed  CAS  Google Scholar 

  54. Tahiliani AG, McNeill JH. 1984. Lack of effect of thyroid homone on diabetic rat heart function and biochemistry. Can J Physiol Pharmacol 62:617–621.

    Article  PubMed  CAS  Google Scholar 

  55. Dillman WH. 1982. Influence of thyroid hormone on myosin ATPase activity and myosin isoenzyme distribution in the heart of diabetic rats. Metabolism 31:199–204.

    Article  Google Scholar 

  56. Xiang H, Heyliger CE, McNeill JH. 1988. Effect of myo-Inositol and T3 on myocardial lipids and cardiac function in streptozotocin-induced diabetic rats. Diabetes 37:1542–1548.

    Article  PubMed  CAS  Google Scholar 

  57. Rodrigues B, Grassby PF, Battell ML, Lee SYN, McNeill JH. 1994. Hypertriglyceridemia in experimental diabetes: relationship to cardiac dysfunction. Can J Physiol Pharmacol 72:447–455.

    Article  PubMed  CAS  Google Scholar 

  58. Nicholl TA, Lopaschuk GD, McNeill JH. 1991. Effects of free fatty acids and dichloroacetate on isolated working diabetic rat heart. Am J Physiol 261:1053–1059.

    Google Scholar 

  59. Verma S, McNeill JH. 1994. Metformin improves cardiac function in isolated streptozotocin-diabetic rat hearts. Am J Physiol 266:714–719.

    Google Scholar 

Download references

Authors
  1. John H. McNeill
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Margaret C. Cam
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nandakumar Sambandam
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Brian Rodrigues
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla (Distinguished Professor), Pawan K. Singal (Professor) & Robert E. Beamish (Professor Emeritus) (Distinguished Professor),  (Professor) &  (Professor Emeritus)

  2. Department of Internal Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda (Associate Professor) (Associate Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

McNeill, J.H., Cam, M.C., Sambandam, N., Rodrigues, B. (1996). Interventions in Experimentally Induced Diabetic Cardiomyopathy. In: Dhalla, N.S., Singal, P.K., Takeda, N., Beamish, R.E. (eds) Pathophysiology of Heart Failure. Developments in Cardiovascular Medicine, vol 168. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1235-2_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1235-2_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8525-0

  • Online ISBN: 978-1-4613-1235-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation