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Impaired Cellular Signaling of the Adenylyl Cyclase and the Phosphoinositide Pathway in Septic Cardiomyopathy

  • Chapter
Pathophysiology of Heart Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 168))

Abstract

The classification of secondary cardiomyopathies is based on “myocardial damage within the scope of a systemic disease.” In view of this definition, myocardial impairment in sepsis and the multiple organ dysfunction syndrome might be reckoned as a secondary form of cardiomyopathy, as septic cardiomyopathy [1]: various infectious disease entities and myocardial virulence factors may trigger common mediator pathways. Thereby, a complex pattern of myocardial depression with different grades of severity may result, characterized on the one hand by common principles (e.g., catecholamine desensitization and the effects of tumor necrosis factor α (TNFα); see below), and on the other hand by toxin-specific and therefore infectious agent-specific pathways (e.g., inhibition of protein synthesis by P. exotoxin A; see below). In a canine model of endotoxin shock, development of myocardial dysfunction indicates a bad prognosis [2]. In patients, heart failure can be documented to a similar degree in various forms of Gram-negative and Gram-positive sepsis and also in fungal sepsis (figure 1).

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Authors
  1. Karl Werdan
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  2. Christopher Reithmann
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Editors and Affiliations

  1. MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla (Distinguished Professor), Pawan K. Singal (Professor) & Robert E. Beamish (Professor Emeritus) (Distinguished Professor),  (Professor) &  (Professor Emeritus)

  2. Department of Internal Medicine Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda (Associate Professor) (Associate Professor)

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Werdan, K. et al. (1996). Impaired Cellular Signaling of the Adenylyl Cyclase and the Phosphoinositide Pathway in Septic Cardiomyopathy. In: Dhalla, N.S., Singal, P.K., Takeda, N., Beamish, R.E. (eds) Pathophysiology of Heart Failure. Developments in Cardiovascular Medicine, vol 168. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1235-2_18

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