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Myocardial 82 RB Kinetics Identify Cell Membrane Integrity and Tissue Viability

  • Chapter
Cardiac Positron Emission Tomography

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 165))

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Abstract

The clinical application of radionuclides in the assessment of residual tissue viability after myocardial infarction or prolonged ischemia is based on the ability of several radioisotopes to delineate cell function, particularly of cell membrane integrity or cellular substrate metabolism. The rationale for their use is based on the experimentally proven fact that only viable cells with intact sarcolemmal membranes can retain the tracers. In contrast, accelerated tracer leakage or inability to trap the radionuclides inside the cell suggests the presence of irreversible cell damage. It is now widely accepted that tracers of cell membrane integrity or cellular metabolism provide accurate noninvasive detection of preserved tissue viability of dysfunctional myocardium in patients with advanced coronary artery disease [1].

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Authors
  1. Jürgen Vom Dahl
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  2. Markus Schwaiger
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Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Technical University in Munich, Klinikum rechts der Isar Ismaninger Strasse 22, D-81675, Munich, Germany

    Markus Schwaiger M.D. (Director and Professor of Medicine, Professor of Internal Medicine) (Director and Professor of Medicine, Professor of Internal Medicine)

  2. Division of Nuclear Medicine Department of Internal Medicine UMH B1 G412 / 0028, University of Michigan Medical Center, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-0028, USA

    Markus Schwaiger M.D. (Director and Professor of Medicine, Professor of Internal Medicine) (Director and Professor of Medicine, Professor of Internal Medicine)

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© 1996 Kluwer Academic Publishers

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Vom Dahl, J., Schwaiger, M. (1996). Myocardial 82 RB Kinetics Identify Cell Membrane Integrity and Tissue Viability. In: Schwaiger, M. (eds) Cardiac Positron Emission Tomography. Developments in Cardiovascular Medicine, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1233-8_14

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  • DOI: https://doi.org/10.1007/978-1-4613-1233-8_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8524-3

  • Online ISBN: 978-1-4613-1233-8

  • eBook Packages: Springer Book Archive

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