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11C-Acetate in the Study of Ischemic Heart Disease

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Cardiac Positron Emission Tomography

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 165))

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Abstract

Nearly 60 years ago, Tennant and Wiggers made the seminal observation that myocardial contraction ceased almost simultaneously with the interruption of coronary blood flow (1). Subsequently, the concept was formulated that myocardial ischemia reflected an imbalance in myocardial oxygen supply (blood flow) and demand [myocardial oxygen consumption (MVO2)], the magnitude of which determined whether an ischemic episode was reversible or myocardial necrosis ensued. Indeed, it was the timely restoration of oxygen supply to reverse this imbalance before myocardial necrosis occurred that formed the basis for the development of thrombolytic therapy in the treatment of patients with acute myocardial infarction.

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Authors
  1. Robert J. Gropler
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Editors and Affiliations

  1. Department of Nuclear Medicine, Technical University in Munich, Klinikum rechts der Isar Ismaninger Strasse 22, D-81675, Munich, Germany

    Markus Schwaiger M.D. (Director and Professor of Medicine, Professor of Internal Medicine) (Director and Professor of Medicine, Professor of Internal Medicine)

  2. Division of Nuclear Medicine Department of Internal Medicine UMH B1 G412 / 0028, University of Michigan Medical Center, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-0028, USA

    Markus Schwaiger M.D. (Director and Professor of Medicine, Professor of Internal Medicine) (Director and Professor of Medicine, Professor of Internal Medicine)

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© 1996 Kluwer Academic Publishers

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Gropler, R.J. (1996). 11C-Acetate in the Study of Ischemic Heart Disease. In: Schwaiger, M. (eds) Cardiac Positron Emission Tomography. Developments in Cardiovascular Medicine, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1233-8_12

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  • DOI: https://doi.org/10.1007/978-1-4613-1233-8_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8524-3

  • Online ISBN: 978-1-4613-1233-8

  • eBook Packages: Springer Book Archive

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