Effects of Nitric Oxide on Red Blood Cells

  • Yann A. Henry


The present chapter shall be divided in an apparently artificial way into three parts. In fact they represent three stages in the understanding of the effects of NO on animals and humans. We shall summarize the effects of NO on hemoglobin within red blood cells (RBC) circulating in the arteriovenous cycle, cells with high metabolic and redox capability. RBC contain hemoglobin at 5 mmol/1 concentration with its allosteric effector 2,3-DPG (also 5 mmol/1), a high reducing pool with GSH (2 mmol/1), methemoglobin (normal concentration being less than 0.1 mmol/1) and the enzymatic system cytochrome b 5 (0.2–0.8 mmol/1) plus methemoglobin reductase (70 nmol/1) (Scheme 5.1).1


Nitric Oxide Electron Paramagnetic Resonance Nitrogen Dioxide Adult Respiratory Distress Syndrome Isosorbide Dini Trate 
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© R.G. Landes Company 1997

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  • Yann A. Henry

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