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General Discussion: Crossregulations of Metalloenzymes Triggered by Nitric Oxide

  • Chapter
Nitric Oxide Research from Chemistry to Biology

Abstract

This final chapter is meant to be a discussion of current results. The divisions into chapters 6, 10, 11 and the present one are in many respects arbitrary. In chapter 6 we have presented EPR results obtained on pure metalloenzymes interacting anaerobically with authentic NO gas in the test tube. Chapter 10 dealt mostly with results obtained with cells either in culture or separated from organ, and activated in vitro. There were the notable exceptions of pure soluble guanylate cyclase and of the isolated proteins of iron metabolism, which could have been treated in chapter 6. In chapter 11, mostly pathological cases were explained, on animal models and on patients whenever possible. In the present chapter, we have gathered recent results, often contradictory at first sight, which hint at several regulation loops triggered by NO synthesis (Table 14.1). All the metalloproteins mentioned here form NO complexes, as proven by EPR spectroscopy (chapter 6), but no useful correlation has yet been made between EPR spectra and cellular functions. So these “left-over” results will be served with almost no EPR “sauce”, which shall be a relief to some nauseated readers reaching this last chapter!

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  1. Yann A. Henry
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Henry, Y.A. (1997). General Discussion: Crossregulations of Metalloenzymes Triggered by Nitric Oxide. In: Nitric Oxide Research from Chemistry to Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1185-0_15

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  • DOI: https://doi.org/10.1007/978-1-4613-1185-0_15

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