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Cell-Mediated Effects of Immunoglobulins pp 117–138Cite as

Internalization through Receptors for Immunoglobulins

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Abstract

All cells eat part of their environment by internalization. Mammalian cells have developed a number of different modes of internalization, which include pinocytosis (the internalization of liquid medium), endocytosis (receptor mediated internalization of soluble molecules) and phagocytosis (internalization of large particles).1 Although the primary function of internalization is nutrition, differentiated cell types have developed specific adaptations of the endocytic process which serve a variety of biological functions. Striking examples are synaptic vesicles in neuronal cells or transcytotic vesicles in epithelia, which represent specialized endocytic vesicles playing crucial roles in synaptic transmission or transport across epithelial barriers, respectively. Cells of the immune system have also developed specialization of their endocytic pathway corresponding to specialized functions related to internalization (like antigen presentation or cytotoxic defense against viral, bacterial and protozoan pathogens). Importantly, receptors for the Fc region of immunoglobulins (FcRs) are involved in most of internalization-related aspects of immune responses.

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  1. Sebastian Amigorena
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© 1997 R.G. Landes Company

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Amigorena, S. (1997). Internalization through Receptors for Immunoglobulins. In: Cell-Mediated Effects of Immunoglobulins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1181-2_5

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  • DOI: https://doi.org/10.1007/978-1-4613-1181-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8501-4

  • Online ISBN: 978-1-4613-1181-2

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