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Lipid Biomarkers of Adherence to Low Fat Diets

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Dietary Fats, Lipids, Hormones, and Tumorigenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 399))

Abstract

The need to lower fat intake in the U.S. has been emphasized in at least fifteen major national dietary recommendations issued since the 1970’s. These include the first Senate Select Committees Dietary Goals in 1977, the Surgeon General’s reports in 1979 and 1988, which laid the groundwork for the concept that changes in food intake could make a significant impact on chronic diseases, the USDA updated guidelines in 1990, and the National Academy of Sciences recommendations, as well as guidelines from the American Cancer Society and the American Institute for Cancer Research1–6. Although the latest periodic study of the U. S. diet, HANES III (National Health and Nutrition Examination Study, 1988–91), shows a downward trend toward an average fat intake of 34%, this still falls short of the recommended 30% or less energy from fat7.

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References

  1. U.S. Congress, Senate 1977a. Dietary Goals for the United States. Report of the Select Committee on Nutrition and Human Needs, stock No. 052-070-03913-2. U.S. Government Printing Office, Washington, D.C.

    Google Scholar 

  2. U.S. Department of Health and Human Services. 1988. Surgeon General’s Report on Nutrition and Health. DHHS (PHS) Publication No. 88-50210. Washington, D.C.:U.S. Government Printing Office.

    Google Scholar 

  3. U.S. Department of Agriculture/Health and Human Services. 1990. Nutrition and Your Health: Dietary Guidelines for Americans, Bulletin No. 232. Washington, D.C: U.S. Government Printing Office.

    Google Scholar 

  4. National Research Council. 1989. Diet and Health: Implications for Reducing Chronic Disease Risk. Committee on Diet and Health, Food and Nutrition Board, Commission on Life Sciences. National Academy Press, Washington, D. C.

    Google Scholar 

  5. Committee on the Dietary Guidelines Implementation. Food and Nutrition Board, Institute of Medicine. 1991. Improving America’s Diet and Health. From Recommendations to Action. National Academy Press. Washington, D.C.

    Google Scholar 

  6. Wynder EL, Cohen LA. Nutritional opportunities find limitations in cancer prevention. Oncology (supplement), 1993; 7(11): 13–16.

    Google Scholar 

  7. Ashley JM. Dietary Guidelines for Cancer Prevention and Control. Oncology (supplement), 1993; 7(11):27–31.

    Google Scholar 

  8. Margetts BM. (1991) Basic issues in designing and interpreting epidemiological research. In: Design Concepts in Nutritional Epidemiology, Margetts BM and Nelson M (eds), Oxford Medical Publications: Oxford.

    Google Scholar 

  9. Sanders TAB, Roshanni F. The influence of different types of n-3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. Clin. Sci., 1983; 64:91–99.

    PubMed  CAS  Google Scholar 

  10. Bates CJ, Thurnham DI: (1991) Biochemical markers of nutrient intake. In: Design Concepts in Nutritional Epidemiology, Margetts BM and Nelson M (eds), Oxford Medical Publications: Oxford

    Google Scholar 

  11. Kris Etherton PM, Krummel D. Russell ME, Dreon D, Mackey S, Borchers J, Wood PD. The effect of diet on plasma lipids, lipoproteins, and coronary heart disease. Am. Diet. Assoc, 1988; 88:1373–1400.

    CAS  Google Scholar 

  12. Beynen AC. Katan MB. Why do polyunsaturated fatty acids lower serum cholesterol? Am. J. Clin. Nutr., 1985; 42,560–563.

    PubMed  CAS  Google Scholar 

  13. McNamara DJ: Dietary fatty acids, lipoproteins, and cardiovascular disease. Advances in Food and Nutrition Research, 1992; 36:253–351.

    Article  PubMed  CAS  Google Scholar 

  14. McNamara, D J, Kolb R, Parker TS, Batwin H, Samuel P, Brown CD, Ahrens EH. Heterogeneity of cholesterol homeostasis in man. Response to changes in dietary fat quality and cholesterol quantity. J. Clin. Invest. 1987; 79, 1729–1739.

    Article  PubMed  CAS  Google Scholar 

  15. Boyd NF, Cousins M, Beaton M, Kriukov V, Lockwood G, Tritchler D: Quantitative changes in dietary fat intake and serum cholesterol in women: results from a randomized, controlled trial. Am. J. Clin. Nutr., 1990; 52:470–476.

    PubMed  CAS  Google Scholar 

  16. Kasim SE, Martino S, Kim P-N, Khilnani S, Boomer A, Depper J, Reading BA, Heilbrun LK. Dietary and anthropometric determinants of plasma lipoproteins during a long-term low-fat diet in healthy women. Am. J. Clin. Nutr. 1993; 57(2): 146–53.

    CAS  Google Scholar 

  17. Katan MB, van Birgelen A, Deslypere JP, Penders M, van Staveren WA. Biological markers of dietary intake, with emphasis on fatty acids. Ann. Nutr. Metab. 1991; 35:249–252.

    Article  PubMed  CAS  Google Scholar 

  18. Weinberg RB, Dantzker C, Patton CS: Sensitivity of serum apolipoprotein A-IV levels to changes in dietary fat content. Gastroenterol., 1990; 98(1):17–24.

    CAS  Google Scholar 

  19. Davidson S, Passmore R, Brock JF, Trusswell AS: (1979) Human Nutrition and Dietetics. Churchill Livingstone, Edinburgh.

    Google Scholar 

  20. Dayton S, Hashimoto S, Dixon W, Pearce ML. Composition of lipids in human serum and adipose tissue during prolonged feeding of a diet high in unsaturated fat. J. Lipid. Res., 1966; 7, 103–111.

    PubMed  CAS  Google Scholar 

  21. Berry EJ, Hirsch J, Most J, McNamara DJ, Thornton J. The relationship of dietary fat to plasma lipid levels as studied by factor analysis of adipose tissue fatty acid composition in a free-living population of middle-aged American men. Am. J. Clin. Nutr. 1986; 44:220–231.

    PubMed  CAS  Google Scholar 

  22. Hirsch J, Farquhar JW, Ahrens EH, Peterson ML, Stoffel W. Studies of adipose tissue in man; A microtechnic for sampling and analysis. Am J. Clin Nutr., 1960; 8:499–511.

    PubMed  CAS  Google Scholar 

  23. Beynen, AC, Hermus RJ, Hautvast JG. A mathematical relationship between the fatty acid composition of the diet and that of the adipose tissue in man. Am. J. Clin. Nutr. 1980; 33: 81–85.

    PubMed  CAS  Google Scholar 

  24. Turpeinen O. (1973) Primary prevention of heart disease by diet. In: DWK Cotton (ed), Lipid Metabolism and Atherosclerosis, Exerpta Medica, Amsterdam, p. 49.

    Google Scholar 

  25. Van Staveren WJ, Durenberg P, Katan MB, Burema J, de Groot LC, Hoffmans MD. Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long-term average fatty acid composition of the diet of separate individuals. Am. J. Epidemiol., 1986; 123:455–463.

    PubMed  Google Scholar 

  26. Hunter DJ, Rimm ER, Sacks FM, Meir J, Stampfer MJ, Colditz GA, Litin B, Willett WC. Comparison of measures of fatty acid intake by subcutaneous fat aspirate, food frequency questionnaire, and diet records in a free-living population of US men. Am. J. Epidemiol. 1992; 135:418–427.

    PubMed  CAS  Google Scholar 

  27. Riboli E., Ronnholm H, Saracci R. Biologic markers of diet. Cancer Surveys, 1987; 6, 685–718.

    PubMed  CAS  Google Scholar 

  28. Stanford JL, King I, Kristal AR. Long-term storage of red blood cells and correlations between red cell and dietary fatty acids: results from a pilot study. Nutr. Cancer, 1991; 16:183–188.

    CAS  Google Scholar 

  29. Hunter DJ, Rimm EB, Sacks FM, Stampfer MJ, Colditz GA, Litin LB, Willett WC. Comparison of measures of fatty acid intake by subcutaneous fat aspirate, food freequency questionnare and diet records in free-living populations of US men. Am. J. Epidemiol., 1992; 135:418–427

    PubMed  CAS  Google Scholar 

  30. London SJ, Sacks FM, Caesar J, Stampfer MJ, Siguel E, and Willett WC. Fatty acid composition of subcutaneous adipose tissue and diet in postmenopausal U.S. women. Am J Clin Nutr 1991; 54:340–345.

    PubMed  CAS  Google Scholar 

  31. Field CJ, Clandinin MT. Modulation of adipose tissue fat compositon by diet: a review. Nutr. Res., 1984; 743–755.

    Google Scholar 

  32. Leaf DA, Connor WE, Barstad L, Sexton G: Incorporation of dietary n-3 fatty acids into the fatty acids of human adipose tissue and plasma lipid classes. Am. J. Clin. Nutr., 1995; 62:68–73.

    PubMed  CAS  Google Scholar 

  33. 29. Leaf DA, Connor WE, Barstad L, Sexton G: Incorporation of dietary n-3 fatty acids into the fatty acids of human adipose tissue and plasma lipid classes. Am. J. Clin. Nutr., 1995; 62:68–73.

    Google Scholar 

  34. Beynen AC and Katan MF. Rapid sampling and long-term storage of sub-cutaneous adipose-tissue biopsies for determination of fatty acid composition. Am. J. Clin. Nutr., 1985; 42, 317–322.

    PubMed  CAS  Google Scholar 

  35. Smith WCS, Tavendale R, Turnstall-Pedoe H. Simplified subcutaneous biopsy for nutritional surveys. Human Nutrition: Clinical Nutriiton, 1986; 400:323–325.

    Google Scholar 

  36. Handelman GJ, Epstein W1, Machlin LJ, van Kuijk F J, Dratz EA. Biopsy method for human adipose with vitamin E and lipid measurements. Lipids 1988; 23:598–604.

    CAS  Google Scholar 

  37. Kuo JG (ed). (1985) Phospholipids and Cellular Regulation. CRC Press, Boca Raton, Florida.

    Google Scholar 

  38. Field CJ, Angel A, Clendenin MT: Relationship of diet to the fatty acid composition of human adipose tissue structure and stored lipids. Am. J. Clin. Nutr., 1985; 42:1206–1220.

    PubMed  CAS  Google Scholar 

  39. Horwitt MK, Harvey CC, Century B. Effects of dietary fats on human erythrocyte fatty acid pattern. J. Clin. Invest., 1959; 42:675–686.

    Google Scholar 

  40. Farquhar JW, Ahrens EH. Effects of dietary fats on human erythrocytes fatty acid pattern. J Clin Invest. 1963:675–686.

    Google Scholar 

  41. Verma SP, Philippot JR, Bonnet B. Raman studies of structural rearrangements induced in human plasma lipoprotein carotenoids by malondialdehyde. Lipids, 1985; 20: 890–96.

    Article  PubMed  CAS  Google Scholar 

  42. Verma SP, Wallach DFH, Sakura JD. Raman analysis of the thermotropic behavior of lecithin-fatty acid systems and of their interaction with proteolipid apoprotein. Biochemistry, 1980; 19: 574–579.

    Article  PubMed  CAS  Google Scholar 

  43. Verma SP, Wallach DFH. Raman spectra of some saturated, unsaturated and deuterated C18 fatty acids in the HCH-deformation and CH-stretching regions. Biochim. Biophys. Acta., 1977; 486:217–227.

    PubMed  CAS  Google Scholar 

  44. Berlin E, Judd JT, Nair PB, Jones DY, Taylor PR. Dietary fat and hormonal influences on lipoprotein fluidity and composition in premenopausal women. Atherosclerosis, 1991: 86:95–110.

    Article  PubMed  CAS  Google Scholar 

  45. Dougherty, R. M., C. Galli, A. Ferro-Luzzi, and J. M. Iacono, Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the U.S.A. Am. J. Clin. Nutr., 1987; 45, 443–455.

    PubMed  CAS  Google Scholar 

  46. Lorenz R, Spengler U, Fischer S, Duhm J, Weber PC. Platelet function, thromboxane formation and blood pressure control during supplementation of the Western diet with cod liver oil. Circulation, 1983; 67:504–511.

    Article  PubMed  CAS  Google Scholar 

  47. Renaud S, Fodsey F, Dumon TF, Thevenon C, Ortchanian E, Martin JL. Influence of long-term diet modificatins on platelet functin and composition in Moselle farmers. Am. J. Clin. Nutr., 1986; 43:136–150.

    PubMed  CAS  Google Scholar 

  48. McMurchie, E. J., B. M. Margetts, L. J. Beilin, K. D. Croft, R. Vandongen, and B. K. Armstrong. Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: Correlation with changes in the dietary polyunsaturated/saturated fat ratio. Am. J. Cain. Nutr, 1984;. 39, 965–980

    Google Scholar 

  49. McMurchie, E. J., J. D. Potter, T. E. Rohan, B. S. Hetze.. Human cheek cells; a non-invasive method for determining tissue lipid profiles in dietary and nutritional studies. Nutr. Rep. Int., 1984; 29, 519–526.

    CAS  Google Scholar 

  50. Moore RA, Oppert S,. Eaton P, Mann JL. Triglyceride fatty acids confirm a change in dietary fat. Clin. Endocrin., 1977; 143–149.

    Google Scholar 

  51. Yamori Y, Nara Y, Iritani N, Workman RJ, Inagami T.. Comparison of serum phospholipid fatty acids among fishing and farming Japanese populations and American inlanders. J. Nutr. Sci. Vitaminol., 1995; 31,417–422.

    Google Scholar 

  52. Van Houwelingerf AC, Kester ADM, Hornstra F. Comparison between habitual intake of polyunsaturated fatty acids from fish and their concentrations in serum lipid fractions. Eur. J. Clin. Nutr., 1989; 43:11–20.

    Google Scholar 

  53. Lepage G, Roy CC. Direct transesterification of all lipids classes in a one step reaction. J. Lipid Res., 1986;27:114–20.

    PubMed  CAS  Google Scholar 

  54. Sarkkinen ES, Agren JJ, Ahola I, Ovaskainen M-L, Uusitupa MIJ. Fatty acid composition of serum cholesterol esters, and erthrocyte and platelet membranes as indicators of long-term adherence to fat-modified diets. Am. J. Clin. Nutr., 1994; 59:364–370.

    PubMed  CAS  Google Scholar 

  55. Lopes M, Trimbo SL, Mascioli EA, Blackburn GL. Human plasma fatty acids and how they are related to dietary intake. Am. J. Clin. Nutr. 1991; 53: 628–37.

    PubMed  CAS  Google Scholar 

  56. Chlebowski RT, Nixon DW, Blackburn GL, et al. Feasibility of using dietary fat intake reduction in adjuvant breast cancer management. Proc ASCO, 1991:10:86,.

    Google Scholar 

  57. Woods MN, Borbach S1, Longscope C, Goldin Br. Low fat, high fiber diet and serum estrone sulfate in premenopausal women. Am. J. Clin. Nutr., 1989; 49:1179–1183.

    PubMed  CAS  Google Scholar 

  58. Lissner L, Levitsky DA, Strupp BJ, Kalkwarf HJ, Roe DA. Dietary fat and the regulation of energy intake in human subjects. Am. J. Clin. Nutr., 1987;46:886–892.

    PubMed  CAS  Google Scholar 

  59. Bouchard C, Bray GA, Hubbard VS. Basic and clinical aspects of regional body fat distribution. Am. J. Clin. Nutr., 1990;52:946–950.

    PubMed  CAS  Google Scholar 

  60. Lee-Han H, Cousins M, Beaton M, McGuire V, Kriukov V, Chipman M, Boyd N. Compliance in a randomized clinical trial of dietary fat reduction in patients with breast dysplasia. Amer.J. Clin. Nut., 1988;48:575–586.

    CAS  Google Scholar 

  61. Heber D, McCarthy WJ, Ashley J. Weight reduction for breast cancer prevention by restriction of dietary fat and calories: rationale, mechanisms and interventions. Nutrition, 1989; 5:149–154, 1989.

    Google Scholar 

  62. Insull W, Henderson MM, Prentice RL. Results of a randomized feasibility study of a low fat diet. Arch. Intern. Med. 1990;150:421–427.

    Article  PubMed  Google Scholar 

  63. Kendall A, Levitsky DA, Strupp BJ, Lissner L. Weight loss on a low-fat diet: consequence of the imprecision of the control of food intake in humans. Am. J. Clin. Nutr., 1991; 53:1124–1129.

    PubMed  CAS  Google Scholar 

  64. Kritchevsky D, Weber MM, Klurfeld DM. Dietary fat vs. caloric content in initiation and promotion of 7,12 dimethyl-benzanthracene-induced mammary tumorigenesis in rats. Cancer Res., 1984; 44:3174–3177.

    PubMed  CAS  Google Scholar 

  65. Heber D.The role of nutrition in cancer prevention and control. Oncology, 1992;6: 9–14.

    PubMed  CAS  Google Scholar 

  66. Bagga D, Ashley JM, Geffrey S, Wang H-J, Barnard J, Elashoff R, and Heber D. Modulation of serum and breast ductal fluid lipids by a very low fat, high fiber diet in premenopausal women. JNCI 1994; submitted in revision.

    Google Scholar 

  67. Heber,D, Ashley JM, McCarthy, WJ, Solares, ME, Leaf,DA, Chang, L-J C, and Elashoff RM. Assessment of adherence to a low fat diet for breast cancer prevention. Prev. Med., 1992; 21: 218–227.

    PubMed  CAS  Google Scholar 

  68. Tangney CC, Shekelle RB, Raymor W, Gale M, Betz EP. Intra and interindividual variation in measurements of B-carotene, retinol and tocopherols in diet and plasma. Am. J. Clin. Nutr., 1987; 45:764–769.

    PubMed  CAS  Google Scholar 

  69. Cabre E, Periago JL, Mingorance MD, Fernandez-Banares F, Abad A, Esteve M, Gil A, Lachiaca M, Gonzalez-Huix F and MA Gassull: Factors related to the plasma fatty acid profile an healthy subjects, with special reference to antioxidant micronutrient status, a multivariate analysis. Am. J. Clin. Nutr., 1992; 55:831–837

    PubMed  CAS  Google Scholar 

  70. Olson, J. A. Serum levels of vitamin A and carotenoids as reflectors of nutritional status. J. Natl. Cancer Inst., 1984; 1439–1444.

    Google Scholar 

  71. Matthews-Roth M, Pathak MA, Fitzpatrick TB, Harbor LC, Kass EH. B-carotene as an oral photoprotec-tive agent in erythrocyte protophorphyrin. J. Am. Med. Assoc, 1974; 228:1004–1008.

    Article  Google Scholar 

  72. 72. Willett WC, Stampfer MJ, Underwood BA, Speizer FE, B. Rosner B, Hennekens CH., Validation of a dietary questionnaire with plasma carotenoid and a-tocopherol levels. Am. J. Clin. Nutr., 183; 38, 631–639.

    Google Scholar 

  73. DeLuca HF. The vitamin D system in the regulation of calcium and phosphorus metabolism. Nutr. Rev., 1979; 37, 161–193.

    Article  PubMed  CAS  Google Scholar 

  74. Parker RS. Carotenoid and tocopherol composition of human adipose tissue. Am. J. Clin. Nutr., 1988; 47, 33–36.

    PubMed  CAS  Google Scholar 

  75. Scott ML. Advances in understanding of vitamin E. Federation Proceedings, 1980; 39:2736–2739.

    PubMed  CAS  Google Scholar 

  76. Farrell PM, Bieri JG. Megavitamin E supplementation in man. Am J. Clin Nutr., 1975; 28:1381–1386.

    PubMed  CAS  Google Scholar 

  77. Garrett-Laster, Oaks M, Russell RM, Oaks RM. A lowering effect of a pharmacological dose of vitamin E on serum vitamin A in normal adults. Nutr. Res., 1981; 1:559–564.

    Article  CAS  Google Scholar 

  78. Willett WC, Stampfer MJ, Underwood BA, Taylor JO, Hennekens CH. Vitamins A, E, and carotene: effects of supplementation on their plasma levels. Am. J. Clin. Nutr., 1983; 38, 559–566.

    PubMed  CAS  Google Scholar 

  79. Behrens WA, Madre R. Alpha- and gamma-tocopherol concentrations in human serum. J. Am. Coll. Nutr.. 1986;5:91–96

    PubMed  CAS  Google Scholar 

  80. Ohlrogge JB, Emken EA, Gulley RM. Human tissue lipids: Occurrence of fatty acid isomers from dietary hydrogenated oils. J. Lipid Res., 1981; 22, 955–960.

    PubMed  CAS  Google Scholar 

  81. Hunter JE, Applewhite TH. Reassessment of trans fatty acid availability in the U.S. diet. Am. J. Clin. Nutr., 1991;54:363–369.

    PubMed  CAS  Google Scholar 

  82. Jonnalagadda SS, Mustad VA, Campagne C, Kris-Etherton PM: Margarine and plasma cholesterol-A perspective for dietitians on trans fatty acids in the diet. Perspectives in Applied Nutrition, 1995; 1(3): 9–16.

    Google Scholar 

  83. Nawar WW. (1985) Lipids. In: Fennema OR (ed). Food Chemistry (Second edition). New York: Marcel Dekker, pp. 139–244.

    Google Scholar 

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Authors and Affiliations

  1. Division of Clinical Nutition, UCLA School of Medicine, Philadelphia, California, 90024, USA

    Judith M. Ashley

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  1. Judith M. Ashley
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  1. University of California, Los Angeles, Philadelphia, California, USA

    David Heber

  2. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

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Ashley, J.M. (1996). Lipid Biomarkers of Adherence to Low Fat Diets. In: Heber, D., Kritchevsky, D. (eds) Dietary Fats, Lipids, Hormones, and Tumorigenesis. Advances in Experimental Medicine and Biology, vol 399. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1151-5_9

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