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The Lactose Permease of Escherichia coli An Update

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Book cover Molecular Biology of Membrane Transport Disorders

Abstract

An unsolved basic biochemical phenomenon of critical importance is the general problem of energy transduction in biological membranes. Although the driving force for a variety of seemingly unrelated functions (e.g., secondary active transport, oxidative phosphorylation, rotation of the bacterial flagellar motor) is a bulk-phase, transmembrane electrochemical ion gradient, the molecular mechanism(s) by which free energy stored in such gradients is transduced into work or into chemical energy remains enigmatic. Nonetheless, gene sequencing and analyses of deduced amino acid sequences indicate that many biological machines involved in energy transduction, secondary transport proteins in particular,1,2 fall into families encompassing proteins from archaebacteria to the mammalian central nervous system, thereby suggesting that the members may have common basic structural features and mechanisms of action. Moreover, certain of these proteins have been implicated in human disease (e.g., glucose/galactose malabsorption, certain forms of drug abuse, depression).

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Department of Physiology, University of California, Los Angeles, California, 90024, USA

    H. Ronald Kaback

  2. Howard Hughes Medical Institute, Department of Microbiology, University of California, Los Angeles, California, 90024, USA

    H. Ronald Kaback

  3. Howard Hughes Medical Institute, Molecular Biology Institute, University of California, Los Angeles, California, 90024, USA

    H. Ronald Kaback

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  1. H. Ronald Kaback
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Editors and Affiliations

  1. University of Texas Medical School at Houston, Houston, Texas, USA

    Stanley G. Schultz

  2. University of Arkansas College of Medicine, Little Rock, Arkansas, USA

    Thomas E. Andreoli

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Arthur M. Brown

  4. The Johns Hopkins University, Baltimore, Maryland, USA

    Douglas M. Fambrough

  5. Yale University School of Medicine, New Haven, Connecticut, USA

    Joseph F. Hoffman

  6. University of Iowa College of Medicine, Iowa City, Iowa, USA

    Michael J. Welsh

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© 1996 Plenum Press, New York

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Kaback, H.R. (1996). The Lactose Permease of Escherichia coli An Update. In: Schultz, S.G., Andreoli, T.E., Brown, A.M., Fambrough, D.M., Hoffman, J.F., Welsh, M.J. (eds) Molecular Biology of Membrane Transport Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1143-0_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1143-0_6

  • Publisher Name: Springer, Boston, MA

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