Disorders of Renal Tubular Transport Processes

  • W. Brian Reeves
  • Thomas E. Andreoli


The glomeruli of individuals with normal renal function deliver, on an average, about 180 liters of plasma ultrafiltrate to the nephrons each day. Included in this vast volume of filtrate are 25,000 mEq of sodium, 4300 mEq of bicarbonate, 700 mEq of potassium, 180 g of glucose, and 10 g of calcium. Indeed, for many of the constituents of the glomerular ultrafiltrate, such as water and sodium, the daily filtered load greatly exceeds the total body content of these substances. One of the primary functions of the nephron, then, is to reabsorb the bulk of the water and solutes presented to it. This process, involving the regulated actions of a wide variety of both active and passive transport pathways proceeding in spatially discrete segments of the nephron, results in a final urine that contains only a small fraction of the original volume and of certain solutes, while other solutes may be present in higher content than in the original glomerular filtrate. That is, certain solutes are avidly absorbed by the nephron while others may undergo net secretion. It also must be emphasized that the resorptive and secretory processes in the kidney are under strict physiologic regulation.


Proximal Tubule Renal Tubular Acidosis Nephrogenic Diabetes Insipidus Fanconi Syndrome Distal Renal Tubular Acidosis 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • W. Brian Reeves
    • 1
  • Thomas E. Andreoli
    • 1
  1. 1.Division of Nephrology and Department of Internal MedicineUniversity of Arkansas College of MedicineLittle RockUSA

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