Gastric Acid Secretion The H,K-ATPase and Ulcer Disease

  • George Sachs
  • Jai Moo Shin
  • Krister Bamberg
  • Christian Prinz


Acid secretion by the parietal cell of the gastric mucosa depends on activation of the acid pump, the gastric H,K-ATPase. This enzyme is expressed in high quantities by the parietal cell. The site of acid secretion in the parietal cell is the secretory canaliculus. This specialized structure is considered to be an infolding of the apical plasma membrane. The active H,K-ATPase is present in the microvilli lining the secretory canaliculus. When inactive the pump is found in cytoplasmic tubules.


Tight Junction Acid Secretion Parietal Cell Gastric Acid Secretion Gastric Parietal Cell 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • George Sachs
    • 1
    • 2
  • Jai Moo Shin
    • 1
    • 2
  • Krister Bamberg
    • 1
    • 2
  • Christian Prinz
    • 1
    • 2
  1. 1.Membrane Biology Laboratory, Department of MedicineUniversity of CaliforniaLos AngelesUSA
  2. 2.Wadsworth VA Medical CenterLos AngelesUSA

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