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Molecular Biology of Membrane Transport Disorders pp 469–483Cite as

Gastric Acid Secretion The H,K-ATPase and Ulcer Disease

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Abstract

Acid secretion by the parietal cell of the gastric mucosa depends on activation of the acid pump, the gastric H,K-ATPase. This enzyme is expressed in high quantities by the parietal cell. The site of acid secretion in the parietal cell is the secretory canaliculus. This specialized structure is considered to be an infolding of the apical plasma membrane. The active H,K-ATPase is present in the microvilli lining the secretory canaliculus. When inactive the pump is found in cytoplasmic tubules.

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Authors and Affiliations

  1. Membrane Biology Laboratory, Department of Medicine, University of California, Los Angeles, USA

    George Sachs, Jai Moo Shin, Krister Bamberg & Christian Prinz

  2. Wadsworth VA Medical Center, Los Angeles, California, 90073, USA

    George Sachs, Jai Moo Shin, Krister Bamberg & Christian Prinz

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  4. Christian Prinz
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Editor information

Editors and Affiliations

  1. University of Texas Medical School at Houston, Houston, Texas, USA

    Stanley G. Schultz

  2. University of Arkansas College of Medicine, Little Rock, Arkansas, USA

    Thomas E. Andreoli

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Arthur M. Brown

  4. The Johns Hopkins University, Baltimore, Maryland, USA

    Douglas M. Fambrough

  5. Yale University School of Medicine, New Haven, Connecticut, USA

    Joseph F. Hoffman

  6. University of Iowa College of Medicine, Iowa City, Iowa, USA

    Michael J. Welsh

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© 1996 Plenum Press, New York

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Sachs, G., Shin, J.M., Bamberg, K., Prinz, C. (1996). Gastric Acid Secretion The H,K-ATPase and Ulcer Disease. In: Schultz, S.G., Andreoli, T.E., Brown, A.M., Fambrough, D.M., Hoffman, J.F., Welsh, M.J. (eds) Molecular Biology of Membrane Transport Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1143-0_23

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  • DOI: https://doi.org/10.1007/978-1-4613-1143-0_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8446-8

  • Online ISBN: 978-1-4613-1143-0

  • eBook Packages: Springer Book Archive

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