Abstract
The central role of cell adhesion in multicellular organisms is self-evident. In order to form functional tissues, cells must physically adhere to one another and to extracellular matrix (ECM) materials. Somewhat more subtle is the role that regulated and selective cell adhesion plays in the development, function, and regeneration of vertebrate organisms. Studies of a variety of biological phenomena by zoologists early in this century led to the formulation of quite specific models of selective cell and tissue affinities1–3 including their hypothetical molecular basis (Figure 2.1). As reflected in this early molecular diagram of the cell membrane, little was known about molecular details of cell adhesion. Nonetheless, as noted in the legend, several of the molecular principles envisioned by Weiss half a century ago have now been given molecular form. During the past 15–20 years, the application of immunologic and molecular genetic tools to these problems has begun to give more detailed form to the hypothetical black bar molecules in Figure 2.1. The list of identified cell adhesion molecules (CAMs) has grown from a handful in 1980 to nearly 100 today.
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© 1996 Plenum Press, New York
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Covault, J. (1996). Cell Adhesion. In: Schultz, S.G., Andreoli, T.E., Brown, A.M., Fambrough, D.M., Hoffman, J.F., Welsh, M.J. (eds) Molecular Biology of Membrane Transport Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1143-0_2
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