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Molecular Biology of Membrane Transport Disorders pp 321–366Cite as

Signal Transduction by G Protein-Coupled Receptors

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Abstract

The primary structure of most of the components involved in G protein-mediated signal transduction are now well known. They include a large family of transmembrane receptors, a large family of heterotrimeric (αβγ) G proteins activated by GTP under the influence of receptors, and a series of molecularly unrelated effectors that are regulated by G protein α, G protein βγ dimer, or both G protein α and βγ dimers (Table 17.1). The list of extracellular compounds depending on G proteins for their signaling includes hormones, neurotransmitters, auto- and paracrine factors. The abundance and diversity of the signaling molecules illustrate the central role of G protein-mediated signal transduzction in cell regulation and body homeostasis.

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Authors and Affiliations

  1. Departments of Anesthesiology and Biological Chemistry, School of Medicine, University of California at Los Angeles, Los Angeles, California, 90095, USA

    Mariel Birnbaumer & Lutz Birnbaumer

  2. Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, 90095, USA

    Mariel Birnbaumer & Lutz Birnbaumer

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  1. Mariel Birnbaumer
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Editors and Affiliations

  1. University of Texas Medical School at Houston, Houston, Texas, USA

    Stanley G. Schultz

  2. University of Arkansas College of Medicine, Little Rock, Arkansas, USA

    Thomas E. Andreoli

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Arthur M. Brown

  4. The Johns Hopkins University, Baltimore, Maryland, USA

    Douglas M. Fambrough

  5. Yale University School of Medicine, New Haven, Connecticut, USA

    Joseph F. Hoffman

  6. University of Iowa College of Medicine, Iowa City, Iowa, USA

    Michael J. Welsh

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© 1996 Plenum Press, New York

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Birnbaumer, M., Birnbaumer, L. (1996). Signal Transduction by G Protein-Coupled Receptors. In: Schultz, S.G., Andreoli, T.E., Brown, A.M., Fambrough, D.M., Hoffman, J.F., Welsh, M.J. (eds) Molecular Biology of Membrane Transport Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1143-0_17

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  • DOI: https://doi.org/10.1007/978-1-4613-1143-0_17

  • Publisher Name: Springer, Boston, MA

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