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Multidrug Resistance Transporter

  • Chapter
Molecular Biology of Membrane Transport Disorders

Abstract

The mechanisms by which cells evade the lethal effects of cytotoxic drugs have been the subject of intense investigation by cell and molecular biologists for more than 20 years. Much of this work was stimulated by the initial success of cancer chemotherapy in disseminated childhood cancers such as leukemias, neuroblastoma, and sarcomas, in germ-cell tumors such as choriocarcinoma and testicular cancer, and in the responsiveness of other cancers such as lymphomas, breast, and ovarian cancers. These clinical successes suggested that metastatic cancer could be cured with chemotherapy, yet in many cases promising remissions were followed by regrowth of drug-resistant cancers. The possibility of cure, coupled with the hope that a defined set of reversible resistance mechanism could be delineated, led to the intense interest in studies of drug resistance.

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Authors and Affiliations

  1. Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Michael M. Gottesman

  2. Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21218, USA

    Suresh V. Ambudkar

  3. Fred Hutchinson Cancer Research Center, Seattle, Washington, 98195, USA

    Marilyn M. Cornwell

  4. Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Ira Pastan

  5. Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, 02139, USA

    Ursula A. Germann

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  1. Michael M. Gottesman
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  2. Suresh V. Ambudkar
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  3. Marilyn M. Cornwell
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  4. Ira Pastan
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  5. Ursula A. Germann
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Editor information

Editors and Affiliations

  1. University of Texas Medical School at Houston, Houston, Texas, USA

    Stanley G. Schultz

  2. University of Arkansas College of Medicine, Little Rock, Arkansas, USA

    Thomas E. Andreoli

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Arthur M. Brown

  4. The Johns Hopkins University, Baltimore, Maryland, USA

    Douglas M. Fambrough

  5. Yale University School of Medicine, New Haven, Connecticut, USA

    Joseph F. Hoffman

  6. University of Iowa College of Medicine, Iowa City, Iowa, USA

    Michael J. Welsh

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© 1996 Plenum Press, New York

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Gottesman, M.M., Ambudkar, S.V., Cornwell, M.M., Pastan, I., Germann, U.A. (1996). Multidrug Resistance Transporter. In: Schultz, S.G., Andreoli, T.E., Brown, A.M., Fambrough, D.M., Hoffman, J.F., Welsh, M.J. (eds) Molecular Biology of Membrane Transport Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1143-0_13

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  • DOI: https://doi.org/10.1007/978-1-4613-1143-0_13

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