Abstract
Cytokines are potent regulating polypeptides or glycoproteins which mediate a variety of biological and physiological processes involved in cellular and humoral immunity, inflammatory reaction as well as hematopoiesis, and also play important roles in host-defense against infection and tumor growth. Abnormal levels of cytokines and growth factors have been shown to be associated with a variety of diseases. For instance, enhanced IL-1ß levels have been reported to be related with sepsis, burn, and rheumatoid arthritis [1–4]. Enhanced erythropoietin (EPO) levels have been found in a series of diseases like certain forms of anemia, and tumors of the kidney or liver [5–7]. Therefore, the information of plasma levels of cytokines as well as growth factors may improve diagnosis, patient follow-up and selection of therapeutic treatments.
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References
Cannon JG, Tompkins RG, Gelfand JA. et al. Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis 1990:161: 79–84.
Cannon JG, Friedberg JS, Gelfand JA, et al. Circulating interleukin-1ß and tumor necrosis factor-α after burn injury in humans. Crit Care Med 1992;20:1414–19.
Eastgate JA, Symons JA, Wood NC, et al. Correlation of plasma interleukin-1 levels with disease activity in rheumatoid arthritis. Lancet 1988:2:706–9.
Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996:87:2095–147.
Jelkmann W. Erythropoietin: structure, control of production, and function. Physiol Review 1992;72:449–89.
Hammond D, Winnick S. Paraneoplastic erythrocytosis and ectopic erythropoietins. Ann NY Acad Sci 1974;230:219–27.
Kew MC, Fisher JW. Serum erythropoietin concentrations in patients with hepatocellular carcinoma. Cancer 1986;58:2485–88.
Gillis S, Ferm MM, Ou W, Smith KA. T cell growth factor: Parameters of production and a quantitative microassay for activity. J Immunol 1978;120:2027–32.
Kitamura T, Tange T, Terasawa T, et al. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF,IL-3, or erythropoietin. J Cell Physiol 1989;140:323–34.
Nordan RP, Pumphrey JG, Rudikoff S. Purification and NH2-terminal sequence of a plasmacytoma growth factor derived from the murine macrophage cell line P388D1. J Immunol 1987;139:813–17.
Aarden LA, de Groot ER, Schaap OL, Lansdorf PM. Production of hybridoma growth factor by human monocytes. Eur J Immunol 1987;17:1411–16.
Avanzi GC, Listra P, Giovinazzo B, et at. Selective growth response to IL-3 of a human leukaemic cell line with megakaryoblastic features. Br J Haematol 1988;69:359–66.
Schroder J-M, Mrowietz U, Morita E, Christophers E. Purification and partial biochemical characterization of ahuman monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity. J Immunol 1987;139:3474–83.
Matsushima K, Larsen CG, duBois GC, Oppenheim JJ. Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J Exp Med 1989; 169:1485–90.
Schall TJ, Bacon K, Toy KJ, Goeddel DV. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 1990;347:669–71.
Aggarwal BB, Kohr WJ, Hass PE, et al. Human tumor necrosis factor. Production, purification, and characterization. J Biol Chem 1985;260:2345–54.
Rubinstein S, Familletti PC, Pestka S. Convenient assay for interferons. J Virol 1981; 37:755–58.
Thorpe R, Wadhwa M, Bird CR, Mire-Sluis AR. Detection and measurement of cytokines. Blood Review 1992;6:133–48.
Boscaro LM, Stuart MC. Incidence and specificity of interference in two-site immunoassays. Clin Chem 1986;32:1491–95.
Boscaro LM, Stuart MC. Heterophilic antibodies: a problem for all immunoassays. Clin Chem 1988;34:27–33.
Matsuda T, Hirano T, Nagasawa S, Kishimoto T. Identification of ß2-macroglobulin as a carrier protein for IL-6. J Immunol 1989;142:148–52.
Borth W, Urbanski A, Prohaska R, Susanj M, Luger TA. Binding of recombinant inter-leukin-1 beta to the third complement and alpha 2-macroglobulin after activation of serum by immune complexes. Blood 1990;75:2388–94.
Crookston KP, Webb DJ, Wolf BB, Gonias SL. Classification of α2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions. J Biol Chem 1994;269:1533–40.
Heaney M, Golde DW. Soluble cytokine receptors. Blood 1996;87:847–57.
Muylle L, Joos M, Wouters E, et al. Increased tumor necrosis factor α (TNF α), interleukin-1, and interleukin-6 (IL-6) levels in the plasma of stored platelet concentrates: relationship between TNFα and IL-6 levels and febrile transfusion reactions. Transfusion 1993;33:195–99.
Stack G, Snyder EL. Cytokine generation in stored platelet concentrates. Transfusion 1994;34:20–5.
Heddle NM, Klama L, Singer J, et al. The role of the plasma from platelet concentrates in transfusion reactions. N Engl J Med 1994:331:625–28.
Sekiguchi S. Donor apheresis: recent advances and future development. Vox Sang 1996;70(Suppl 3):126–34.
Takahashi TA, Fujihara M, Ogiso C, Hosoda M, Sekiguchi S. Cytokine level determination in stored apheresis platelet concentrates. Transfusion 1995;35(Suppl): 44S.
Yamamoto S, Nakase T, Sato N, Ikebuchi K, Sadayoshi S. Automatic pre-storage filtration system for platelet apheresis. Jpn J Med Instrument 1996;66:482–88.
Bubel S, Wilhelm D, Entelmann M, Kirchner H, Kluter H. Chemokines in stored platelet concentrates. Transfusion 1996;36:445–49.
Wadhwa M, Seghatchian MJ, Lubenko A, et al. Cytokine levels in platelet concentrates: quantitation by bioassays and immunoassays. Br J Haematol 1996;93:225–34.
Stack G, Cole S. Accumulation of the cytokines TGF-ß1 and RANTES in stored platelet concentrates. Transfusion 1995;35(Suppl):45S.
Zuker MB, Katz IR. Platelet factor 4: Production, structure, and physiologic and immunologic action. Proc Soc Exp Biol Med 1991;198:693–702.
Bischoff SC, Krieger M, Brunner T, et al. RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors. Eur J Immunol 1993;23:761–67.
Giraddin E, Grau GE, Dayer JM, et al. Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N Engl J Med 1988;619:397–400.
Hack CE, de Groot ER, Felt-Bersma RJF, et al. Increased plasma levels of interleukin-6 in sepsis. Blood 1989;74:1704–10.
Debets JMH, Kampmeijer R, van der Linden MPMH, Buurman WA, van der Linden CJ. Plasma tumor necrosis factor and mortality in critically ill septic patients. Crit Care Med 1989;17:489–94.
Damas P, Reuter A, Gysen P, et al. Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit Care Med 1989; 17:975–78.
Calandra T, Baumgartner J-D, Grau GE, et al. Prognostic value of tumor necrosis factor/cachectin, interleukin-1, interferon-α, and interferon-γ in the serum of patients with septic shock. J Infect Dis 1990;161:982–87.
Calandra T, Gerain J, Heumann D, et al. High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. Am J Med 1991;91:23–9.
Damas P, Ledoux D, Nys M, et al. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg 1991;215:356–62.
Pinsky MR, Vincent J-L, Deviere J, et al. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest 1993; 103:565–75.
Casey LC, Balk RA, Bone RC. Plasma cytokines and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993; 119:771–78.
Marty C, Misset B, Tamion F, et al. Circulating interleukin-8 concentrations in patients with multiple organ failure of septic and nonseptic origin. Crit Care Med 1994;22: 673–79.
Dinarello C, Cannon JG. Cytokine measurements in septic shock. Ann Intern Med 1993;119:853–54.
Remberger M, Ringden O, Markling L. TNFα levels are increased during bone marrow transplantation conditioning in patients who develop acute GvHD. Bone Marrow Transplant 1995;15:99–104.
Miyamoto T, Akashi k, Hayashi S, et al. Serum concentration of the soluble inter-leukin-2 receptor for monitoring acute graft-versus-host disease. Bone Marrow Transplant 1996;17:185–90.
Kutukculer N, Clark K, Rigg KM, et al. The value of posttransplant monitoring of interleukin (IL)-2, IL-3, IL-4, IL-6, IL-8, and soluble CD23 in the plasma of renal allograft recipients. Transplantation 1995;59:333–40.
Deng MC, Erren M, Kammerling L, et al. The relation of interleukin-6, tumor necrosis factor-α, IL-2, and IL-2 receptor levels to cellular rejection, allograft dysfunction, and clinical events early after cardiac transplantation. Tranplantation 1995;60:1118–24.
Kaminski ER, Kaminski A, Bending MR, et al. In vitro cytokine profiles and their relevance to rejection following renal transplantation. Transplantation 1995;60:703–6.
Umeshita K, Monden M, Tono T, et al. Determination of the presence of interleukin-6 in bile after orthotopic liver transplantation. Its role in the diagnosis of acute rejection. Ann Surg 1996;223:204–11.
Carre PC, Mortenson RL, King TE Jr, et al. Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis. J Clin Invest 1991;88: 1802–10.
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Fujihara, M., Ikebuchi, K., Yamamoto, S., Nakase, T., Sekiguchi, S. (1997). Use and Application of Cytokines and Growth Factors in Laboratory Diagnostic Procedures. In: Sibinga, C.T.S., Das, P.C., Löwenberg, B. (eds) Cytokines and Growth Factors in Blood Transfusion. Developments in Hematology and Immunology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1137-9_5
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DOI: https://doi.org/10.1007/978-1-4613-1137-9_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8435-2
Online ISBN: 978-1-4613-1137-9
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