Recipient Immune Responses Induced by Allogeneic Whole Blood or Platelet Transfusions: Implications for Immunomodulation

  • J. W. Semple
  • D. Cosgrave
  • E. R. Speck
  • A. Bang
  • V. S. Blanchette
  • J. Freedman
Part of the Developments in Hematology and Immunology book series (DIHI, volume 32)


CD4+ T helper (Th) cell responses can be divided in Th0, Thl and Th2 [1-4]. These responses are categorized based on the identification of cytokines. Thl-like responses generally produce interleukin (IL)-2/interferon-γ (IFN-γ), primarily mediate cell mediated immunity and, in mice, induce the synthesis of IgG2a antibodies whereas Th2-like responses on the other hand generally produce IL-4, IL-5, IL-6 and IL-10 and are superior at inducing IgG1 and IgE humoral immunity [1-4]. Th0-like responses are thought to be less differentiated than those mediating Thl and Th2 responses because cytokines characteristic of both e.g. IL-4, IFN-γ and IL-10, etc. can be identified. What makes these patterns of cytokines so intriguing is that they appear to be associated with different immune functions. With respect to transplantation, for example, there is compelling evidence that Thl responses are associated with graft rejection [5-9], whereas Th2 responses may be correlated with immune tolerance towards the graft [10–13].


Platelet Transfusion Whole Blood Heart Allograft Renal Allograft Survival Liver Allograft Rejection 
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© Kluwer Academic Publishers 1997

Authors and Affiliations

  • J. W. Semple
  • D. Cosgrave
  • E. R. Speck
  • A. Bang
  • V. S. Blanchette
  • J. Freedman

There are no affiliations available

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