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Recipient Immune Responses Induced by Allogeneic Whole Blood or Platelet Transfusions: Implications for Immunomodulation

  • Chapter
Cytokines and Growth Factors in Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 32))

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Abstract

CD4+ T helper (Th) cell responses can be divided in Th0, Thl and Th2 [1-4]. These responses are categorized based on the identification of cytokines. Thl-like responses generally produce interleukin (IL)-2/interferon-γ (IFN-γ), primarily mediate cell mediated immunity and, in mice, induce the synthesis of IgG2a antibodies whereas Th2-like responses on the other hand generally produce IL-4, IL-5, IL-6 and IL-10 and are superior at inducing IgG1 and IgE humoral immunity [1-4]. Th0-like responses are thought to be less differentiated than those mediating Thl and Th2 responses because cytokines characteristic of both e.g. IL-4, IFN-γ and IL-10, etc. can be identified. What makes these patterns of cytokines so intriguing is that they appear to be associated with different immune functions. With respect to transplantation, for example, there is compelling evidence that Thl responses are associated with graft rejection [5-9], whereas Th2 responses may be correlated with immune tolerance towards the graft [10–13].

This work was supported by a grant (TO.02.95) form the Canadian Red Cross Blood Services

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Authors
  1. J. W. Semple
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  2. D. Cosgrave
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  3. E. R. Speck
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  4. A. Bang
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  5. V. S. Blanchette
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  6. J. Freedman
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Editor information

Editors and Affiliations

  1. Red Cross Blood Bank Noord Nederland, The Netherlands

    Cees Th. Smit Sibinga (Initiator and Organiser) & P. C. Das (Initiator and Organiser) & 

  2. Erasmus University, Rotterdam, The Netherlands

    Bob Löwenberg (Chairman) (Chairman)

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© 1997 Kluwer Academic Publishers

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Semple, J.W., Cosgrave, D., Speck, E.R., Bang, A., Blanchette, V.S., Freedman, J. (1997). Recipient Immune Responses Induced by Allogeneic Whole Blood or Platelet Transfusions: Implications for Immunomodulation. In: Sibinga, C.T.S., Das, P.C., Löwenberg, B. (eds) Cytokines and Growth Factors in Blood Transfusion. Developments in Hematology and Immunology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1137-9_4

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  • DOI: https://doi.org/10.1007/978-1-4613-1137-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8435-2

  • Online ISBN: 978-1-4613-1137-9

  • eBook Packages: Springer Book Archive

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