Recipient Immune Responses Induced by Allogeneic Whole Blood or Platelet Transfusions: Implications for Immunomodulation
CD4+ T helper (Th) cell responses can be divided in Th0, Thl and Th2 [1-4]. These responses are categorized based on the identification of cytokines. Thl-like responses generally produce interleukin (IL)-2/interferon-γ (IFN-γ), primarily mediate cell mediated immunity and, in mice, induce the synthesis of IgG2a antibodies whereas Th2-like responses on the other hand generally produce IL-4, IL-5, IL-6 and IL-10 and are superior at inducing IgG1 and IgE humoral immunity [1-4]. Th0-like responses are thought to be less differentiated than those mediating Thl and Th2 responses because cytokines characteristic of both e.g. IL-4, IFN-γ and IL-10, etc. can be identified. What makes these patterns of cytokines so intriguing is that they appear to be associated with different immune functions. With respect to transplantation, for example, there is compelling evidence that Thl responses are associated with graft rejection [5-9], whereas Th2 responses may be correlated with immune tolerance towards the graft [10–13].
KeywordsPlatelet Transfusion Whole Blood Heart Allograft Renal Allograft Survival Liver Allograft Rejection
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