Vaccination Strategies to Induce T-Cell Immunity Against Tumours

  • M. E. Ressing
  • R. E. M. Toes
  • R. M. P. Brandt
  • E. I. H. van der Voort
  • J. H. de Jong
  • W. M. Kast
  • R. Offringa
  • C. J. M. Melief
Chapter
Part of the Developments in Hematology and Immunology book series (DIHI, volume 32)

Abstract

Effector T cells recognize immunogenic peptides that are presented on the cell membrane in the context of major histocompatibility complex (MHC) molecules. The vast majority of T cells consists of either CD8+ cytotoxic T lymphocytes (CTL) or CD4+ T helper cells. By and large, MHC class I molecules present antigenic peptides to CTL, whereas T helper cells recognize antigenic peptides in the context of MHC class II molecules. These proteins are mainly found on the cells of the immune system with a specialized antigen presenting function. In general, CD4+ lymphocytes secrete cytokines upon triggering that controles the activation of B cells, macrophages and CD8+ cells. MHC class I molecules are expressed on the cell surface of virtually all nucleated cells and present peptides derived from endogenously synthesized proteins to CTL. This enables the CTL to screen almost all cells of the body for antigenic peptides that may be presented as a consequence of viral infection or malignant transformation. Therefore, the CD8+ CTL represent a major effector subset of tumour-specific T cells responsible for rejection of tumours.

Keywords

Hepatitis Lymphoma Influenza Sarcoma Meningitis 

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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • M. E. Ressing
  • R. E. M. Toes
  • R. M. P. Brandt
  • E. I. H. van der Voort
  • J. H. de Jong
  • W. M. Kast
    • 1
  • R. Offringa
  • C. J. M. Melief
  1. 1.Cancer Immunology ProgramLoyola University Cancer CenterMaywoodUSA

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