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Vaccination Strategies to Induce T-Cell Immunity Against Tumours

  • Chapter
Book cover Cytokines and Growth Factors in Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 32))

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Abstract

Effector T cells recognize immunogenic peptides that are presented on the cell membrane in the context of major histocompatibility complex (MHC) molecules. The vast majority of T cells consists of either CD8+ cytotoxic T lymphocytes (CTL) or CD4+ T helper cells. By and large, MHC class I molecules present antigenic peptides to CTL, whereas T helper cells recognize antigenic peptides in the context of MHC class II molecules. These proteins are mainly found on the cells of the immune system with a specialized antigen presenting function. In general, CD4+ lymphocytes secrete cytokines upon triggering that controles the activation of B cells, macrophages and CD8+ cells. MHC class I molecules are expressed on the cell surface of virtually all nucleated cells and present peptides derived from endogenously synthesized proteins to CTL. This enables the CTL to screen almost all cells of the body for antigenic peptides that may be presented as a consequence of viral infection or malignant transformation. Therefore, the CD8+ CTL represent a major effector subset of tumour-specific T cells responsible for rejection of tumours.

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Authors and Affiliations

  1. Cancer Immunology Program, Loyola University Cancer Center, 2160 South First Ave., Maywood, IL, 60153, USA

    W. M. Kast

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  1. M. E. Ressing
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  2. R. E. M. Toes
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  3. R. M. P. Brandt
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  4. E. I. H. van der Voort
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  5. J. H. de Jong
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  6. W. M. Kast
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  7. R. Offringa
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  8. C. J. M. Melief
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Editors and Affiliations

  1. Red Cross Blood Bank Noord Nederland, The Netherlands

    Cees Th. Smit Sibinga (Initiator and Organiser) & P. C. Das (Initiator and Organiser) & 

  2. Erasmus University, Rotterdam, The Netherlands

    Bob Löwenberg (Chairman) (Chairman)

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© 1997 Kluwer Academic Publishers

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Ressing, M.E. et al. (1997). Vaccination Strategies to Induce T-Cell Immunity Against Tumours. In: Sibinga, C.T.S., Das, P.C., Löwenberg, B. (eds) Cytokines and Growth Factors in Blood Transfusion. Developments in Hematology and Immunology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1137-9_14

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