Analysis of food contaminants by combined liquid chromatography—mass spectrometry (LC—MS)

  • John Gilbert

Summary

Over the past ten years there have been significant advances in LC—MS both in terms of the development of new interfaces and in the availability of more reliable, robust and lower cost instrumentation. Thermospray, particle beam, electrospray and atmospheric pressure chemical ionisation interfaces are briefly described and compared, and advances in coupling of MS with supercritical fluid chromatography and capillary electrophoresis are outlined. The two major areas where LC—MS applications have increased in recent years have been for pesticide and veterinary drug residues, and these are reviewed, citing in particular examples where LC—MS now offers the capability of analysing polar and higher molecular weight residues which have previously proved less amenable to other techniques. More isolated examples of applications of LC—MS are found in the areas of mycotoxins, natural toxicants, food additives and packaging migration, which go some way to demonstrating the potential for further new applications.

Keywords

Triazine Paraquat Chlorpyrifos Carbaryl Oxytetracycline 

Abbreviations

APCI

atmospheric pressure chemical ionisation

API

atmospheric pressure ionisation

CE

capillary electrophoresis

CE—MS

combined capillary electrophoresis mass spectrometry

CI

chemical ionisation

CID

collision-induced decomposition

CV

coefficient of variation

DON

4-deoxynivalenol mycotoxin

DLI

direct liquid introduction LC-MS

DSP

diarrhetic shellfish poisoning

EI

electron ionisation

ETU

ethylene thiourea

FAB

fast atom bombardment

GC

gas chromatography

GC—MS

combined gas chromatography—mass spectrometry

HPLC

high performance liquid chromatography

ITP

isotachophoresis

LC—MS

combined liquid chromatography—mass spectrometry

MRL

maximum residue limit

MS

mass spectrometry

MS—MS

tandem mass spectrometry—mass spectrometry

MWt

molecular weight

NI

negative ionisation (or ion)

NICI

negative ion chemical ionisation

NIV

nivalenol mycotoxin

OCs

organochlorine pesticides

OPs

organophosphorus pesticides

PET

poly(ethylene terephthalate)

PI

positive ionisation (or ion)

PSP

paralytic shellfish poisoning

SFC

supercritical fluid chromatography

SIM

selected ion monitoring

SMC

sterimatocystin

TLC

thin-layer chromatography

UV

ultraviolet

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© Chapman & Hall 1996

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  • John Gilbert

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