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Prioritization of possible carcinogenic hazards in food

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Abstract

Epidemiological studies have identified several factors that are likely to have a major effect on reducing rates of cancer: reduction of smoking, increased consumption of fruits and vegetables, and control of infections. Other factors include avoidance of intense sun exposure, increased physical activity, reduction of high occupational exposures, and reduced consumption of alcohol and possibly red meat. Risks of many forms of cancer can already be lowered, and the potential for further risk reduction is great. In the USA cancer death rates for all cancers combined are decreasing, if lung cancer — 90% of which is due to smoking — is excluded from the analysis (Ames et al., 1995). The focus of this chapter is prioritization of possible cancer hazards in the diet.

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References

  • Ahmet, S.S. and Miiller, K. (1978) Effect of wound-damages on the glyco-alkaloid content in potato tubers and chips. Lebensmittel-Wissenschaft Technologies 11, 144–146.

    Google Scholar 

  • American Water Works Association (1993) Disinfectant/Disinfection By-Products Database for the Negotiated Regulation. AWWA, Washington, DC.

    Google Scholar 

  • Ames, B.N. (1983) Dietary carcinogens and anti-carcinogens: oxygen radicals and degenerative diseases. Science, 221, 1256–1264.

    Article  CAS  Google Scholar 

  • Ames, B.N. (1984) Cancer and diet. Science, 224, 668–670, 757–760.

    CAS  Google Scholar 

  • Ames, B.N. and Gold, L.S. (1987) Science, 238, 1633–1634.

    Article  Google Scholar 

  • Ames, B.N. and Gold, L.S. (1988) Reply to letter to the editor: Carcinogenic risk estimation. Science 240, 1043–1047.

    Article  Google Scholar 

  • Ames, B.N. and Gold, L.S. (1989) Letter to the editor: Pesticides, risk and applesauce. Science 240, 1040–1047.

    Google Scholar 

  • Ames, B.N. and Gold, L.S. (1990) Chemical carcinogenesis: too many rodent carcinogens. Proceedings of the National Academy of Sciences of the USA 87 7772–7776.

    Article  CAS  Google Scholar 

  • Ames, B.N., Magaw, R. and Gold, L.S. (1987a) Ranking possible carcinogenic hazards. Science 236 271–280.

    Article  CAS  Google Scholar 

  • Ames, B.N., Magaw, R. and Gold, L.S. (1987b) Reply to letter to the editor: Risk assessment. Science, 237, 235.

    Google Scholar 

  • Ames, B.N., Magaw, R. and Gold, L.S. (1987c) Reply to letter to the editor: Carcinogenicity of aflatoxins. Science, 237, 1283–1284.

    Article  Google Scholar 

  • Ames, B.N., and Gold, L.S. (1987d) Reply to letter to the editor: Risk assessment. Science, 237, 1399–1400.

    Article  Google Scholar 

  • Ames, B.N., Profet, M. and Gold, L.S. (1990a) Dietary pesticides (99.99% all natural). Proceedings of the National Academy of Sciences of the USA, 87, 7777–7781.

    Article  CAS  Google Scholar 

  • Ames, B.N., Profet, M. and Gold, L.S. (1990b) Nature’s chemicals and synthetic chemicals: comparative toxicology. Proceedings of the National Academy of Sciences of the USA, 87, 7782–7786.

    Article  CAS  Google Scholar 

  • Ames, B.N., Shigenaga, M.K. and Hagen, T.M. (1993a) Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the National Academy of Sciences of the USA, 90, 7915–7922.

    Article  CAS  Google Scholar 

  • Ames, B.N., Shigenaga, M.K. and Gold, L.S. (1993b) DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. Environmental Health Perspectives, 101(Suppl. 5), 35–44.

    Article  CAS  Google Scholar 

  • Ames, B.N., Gold, L.S. and Willett, W.C. (1995) The causes and prevention of cancer. Proceedings of the National Academy of Sciences of the USA, 92, 5258–5265.

    Article  CAS  Google Scholar 

  • Ariza, R.R., Dorado, G., Barbanch, M. and Pueyo. C. (1988) Study of the causes of direct- acting mutagenicity in coffee and tea using the Ara test in Salmonella typhimurium. Mutation Research, 201, 89–96.

    CAS  Google Scholar 

  • Arkima, V. (1968) Die quantiative gaschromatographische Bestimmung der hoheren aliphatischen und aromatischen Alkohole im Bier. Monatschrift Brauerei, 21, 25–27.

    CAS  Google Scholar 

  • Armstrong, B. and Doll, R. (1975) Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. International Journal of Cancer 15, 617–631.

    Article  CAS  Google Scholar 

  • Baltes, W. (1977) Rösteffekte auf die Kaffeezusammensetzung. Colloque Scientifique International sur le Café. 8, 85–96.

    CAS  Google Scholar 

  • Bendich, A. and Butterworth C.E. Jr. (eds) (1991) Micronutrients in Health and in Disease Prevention. Marcel Dekker, New York.

    Google Scholar 

  • Bernstein, L., Gold, L.S., Ames, B.N. et al. (1985) Some tautologous aspects of the comparison of carcinogenic potency in rats and mice. Fundamental and Applied Toxicology, 5, 79–86.

    Article  CAS  Google Scholar 

  • Block, G., Patterson, B. and Subar, A. (1992) Fruit, vegetables and cancer prevention: a review of the epidologic evidence. Nutrition and Cancer 18, 1–29.

    Article  CAS  Google Scholar 

  • Blount, B.C., Mack M.M., Wehr C. et al. (1997) Folate deficiency causes uracil misincor- poration into human DNA and chromosome breakage: Implications for cancer and neuronal damage. Proceedings of the National Academy of Sciences of the USA, 94, 3290–3295.

    Article  CAS  Google Scholar 

  • Bokanga, E., Essers, A J. A., Poulter, N. et al. (eds) (1994) International Workshop on Cassava Safety. Acta Horticulturae, 375. International Society for Horticultural Science. Wageningen, Netherlands.

    Google Scholar 

  • Bradfield, C.A. and Bjeldanes, L.F. (1987) Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism. Journal of Toxicology and Environmental Health 21, 311–323.

    Article  CAS  Google Scholar 

  • Bushway, R.J. and Ponnampalam, R. (1981) α-Chaconine and a-solanine content of potato products and their stability during several modes of cooking. Journal of Agriculture and Food Chemistry 29, 814–817.

    Article  CAS  Google Scholar 

  • California Environmental Protection Agency, Standards and Criteria Work Group (1994) California Cancer Potency Factors: Update. CaPA, Sacramento.

    Google Scholar 

  • Clarke, R.J. and Macrae, R. (eds) (1988) Coffee. Vols 1–3. Elsevier, New York.

    Google Scholar 

  • Clayson, D.B., Iverson, F., Ñera, E.A. and Lok, E. (1990) The significance of induced forestomach tumors. Annual Review of Pharmacology and Toxicology, 30, 441–463.

    Article  CAS  Google Scholar 

  • Clinton, W.P. (1986) The chemistry of coffee. Colloque Scientifique International sur le Café, 11, 87–92.

    Google Scholar 

  • Cohen, S.M. (1995) Human relevance of animal carcinogenicity studies. Regulatory Toxicology and Pharmacology 21, 75–80.

    Article  CAS  Google Scholar 

  • Cohen, S.M. and Ellwein, L.B. (1991) Genetic errors, cell proliferation, and carcinogenesis. Cancer Research, 51, 6493–6505.

    CAS  Google Scholar 

  • Cohen, S.M. and Lawson, T.A. (1995) Rodent bladder tumors do not always predict for humans. Cancer Letters, 93, 9–16.

    Article  CAS  Google Scholar 

  • Counts, J.L. and Goodman, J.I. (1995) Principles underlying dose selection for, and extrapolation from, the carcinogen bioassay: dose influences mechanism. Regulatory Toxicology and Pharmacology, 21, 418–421.

    Article  CAS  Google Scholar 

  • Coxon, D.T., Curtis, R.F. and Howard, B. (1975) Ipomeamarone, a toxic furanoterpenoid in sweet potatoes (Ipomea batatas) in the United Kingdom. Food and Cosmetic Toxicology, 13, 87–90.

    Article  CAS  Google Scholar 

  • Cunningham, M.L., Pippin, L.L., Anderson, N.L. and Wenk, M.L. (1995) The hepatocar- cinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study. Toxicology and Applied Pharmacology, 131, 216–223.

    Article  CAS  Google Scholar 

  • Davies, T.S. and Monro, A. (1995) Marketed human pharmaceuticals reported to be tumorigenic in rodents. J. Am. Coll. Toxicol, 14, 90–107.

    CAS  Google Scholar 

  • Dietrich, D.R. and Swenberg, J.A. (1991) The presence of α2u-globulinis necessary for d- limonene promotion of male rat kidney tumors. Cancer Research, 51, 3512–3521.

    CAS  Google Scholar 

  • Doll, R. and Peto, R. (1981) The Causes of Cancer. Oxford University Press, New York.

    Google Scholar 

  • Duggan, R.E. and Corneliussen, P.E. (1972) Dietary intake of pesticide chemicals in the United States (III), June 1968-April 1970. Pesticide Monitoring Journal, 5, 331–341.

    CAS  Google Scholar 

  • Economic Research Service (1994) Vegetables and Specialties Situation and Outlook Yearbook. US Department of Agriculture, Washington, DC.

    Google Scholar 

  • Economic Research Service (1995) Fruit and Tree Nuts Situation and Outlook Yearbook. US Department of Agriculture, Washington, DC.

    Google Scholar 

  • Everson, R.B., Wehr, C.M., Erexson, G.L. and Maregor, J.T. (1988) Association of marginal folate depletion with increased human chromasomal damage in vivo: demonstration by analysis of micronucleated erythrocytes. Journal of the National Cancer Institute, 80, 525–529.

    Article  CAS  Google Scholar 

  • Fraga, C.G., Motchik, P.A., Shigenaga, M.K. et al. (1991) Ascorbic acid protects against endogenous oxidative damage in human sperm. Proceedings of the National Academy of Sciences of the USA, 88, 11003–11006.

    Article  CAS  Google Scholar 

  • Freedman, D.A., Gold, L.S. and Slone, T.H. (1993) How tautological are inter-species correlations of carcinogenic potency? Risk Analysis, 13, 265–272.

    Article  CAS  Google Scholar 

  • Freudenheim, J.L., Graham, S., Marshall, J.R. et al. (1991) Folate intake and carcinogenesis of the colon and rectum. International Journal of Epidemiology 20, 368–374.

    Article  CAS  Google Scholar 

  • Fujita, Y., Wakabayashi, K., Nagao, M. and Sugimura, T. (1985) Implication of hydrogen peroxide in the mutagenicity of coffee. Mutation Research, 144, 227–230.

    Article  CAS  Google Scholar 

  • Fung, V.A., Cameron, T.P., Hughes, T.J. et al. (1988) Mutagenic activity of some coffee flavor ingredients. Mutation Research, 204, 219–228.

    Article  CAS  Google Scholar 

  • Gartrell, M.J., Craun, J.C., Podrebarac, D.S. and Gunderson, E.L. (1986) Pesticides, selected elements, and other chemicals in adult total diet samples October 1980-March 1982. Journal of the Association of Official Analytical Chemists, 69, 146–161.

    CAS  Google Scholar 

  • Gaylor, D.W. and Gold, L.S. (1995) Quick estimate of the regulatory virtually safe dose based on the maximum tolerated dose for rodent bioassays. Regulatory Toxicology and Pharmacology, 22, 57–63.

    Article  CAS  Google Scholar 

  • Gerhardsson, M., Floderus, B. and Norell, S.E. (1988) Physical activity and colon cancer risk. International Journal of Epidemiology, 17, 743–746.

    Article  CAS  Google Scholar 

  • Giovannucci, E., Rimm, E.B., Stampfer, M.J. et al. (1994) Intake of fat, meat, and fiber in relation to risk of colon cancer in men. Cancer Research, 54, 2390–2397.

    CAS  Google Scholar 

  • Giovannucci, E., Rimm, E.B., Ascherio, A. et al. (1995) Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. Journal of the National Cancer Institute, 87, 265–273.

    Article  CAS  Google Scholar 

  • Gold, L.S., Sawyer, C.B., Magaw, R. et al. (1984) A Carcinogenic Potency Database of the standardized results of animal bioassays. Environmental Health Perspectives, 58, 9–319.

    Article  CAS  Google Scholar 

  • Gold, L.S., de Veciana, M., Backman, G.M. et al. (1986) Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982. Environmental Health Perspectives, 67, 161–200.

    Article  CAS  Google Scholar 

  • Gold, L.S., Slone, T.H., Backman, G.M. et al. (1987) Second chronological supplement to the Carcingenic Potency Database: standardized results of animal bioassays published through December 1984 and by the National Toxicology Program through May 1986. Environmental Health Perspectives, 74, 237–329.

    Article  CAS  Google Scholar 

  • Gold, L.S., Slone, T.H., Backman, G.M. et al. (1990) Third chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987. Environmental Health Perspectives, 84, 215–286.

    Article  CAS  Google Scholar 

  • Gold, L.S., Slone, T.H., Stern, B.R. (1992a) Rodent carcinogens: setting priorities. Science, 258, 261–265.

    Article  CAS  Google Scholar 

  • Gold, L.S., Manley, N.B. and Ames, B.M. (1992b) Extrapolation of carcinogenesis between species: qualitative and quantitative factors. Risk Analysis, 12, 579–588.

    Article  CAS  Google Scholar 

  • Gold, L.S., Manley, N.B., Slone, T.H. et al. (1993) The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989. Environmental Health Perspectives, 100, 65–135.

    Article  CAS  Google Scholar 

  • Gold, L.S., Slone, T.H., Manley, N.B. and Ames, B.N. (1994a) Heterocyclic amines formed by cooking food: comparison of bioassay results with other chemicals in the Carcinogenic Potency Database. Cancer Letters, 83, 21–29.

    Article  CAS  Google Scholar 

  • Gold, L.S., Garfinkel, G.B. and Slone, T.H. (1994b) Setting priorities among possible carcinogenic hazards in the workplace. In: Smith, C.M., Christiani, D.C. and Kelsey, K.T. (eds) Chemical Risk Assessment and Occupational Health: Current Applications, Limitations, and Future Prospects. Auburn House Westport, CT, pp. 91–103.

    Google Scholar 

  • Gold, L.S., Manley, N.B., Slone, T.H. et al. (1995) Sixth Plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature 1989–1990 and by the National Toxicology Program 1990–1993. Environmental Health Perspectives, 103(Suppl. 8), 3–122.

    Article  CAS  Google Scholar 

  • Gold, L.S., Slone, T.H.. Manley. N.B. et al. (1997a) Carcinogenic Potency Database. In: Gold, L.S. and Zeiger. E. (eds) Handbook of Carcinogenic Potency and Genotoxicity Databases. CRC Press. Boca Raton. FL, 1–605.

    Google Scholar 

  • Gold, L.S., Slone, T.H. and Ames, B.N. (1997b) Overview of analyses of the Carcinogenic Potency Database. In: Gold, L.S. and Zeiger, E. (eds) Handbook of Carcinogenic Potency and Genotoxicity Databases. CRC Press, Boca Raton, FL, 651–685.

    Google Scholar 

  • Goldbohm, R.A., van den Brandt, P.A., van’t Veer, P. et al. (1994) A prospective cohort study on the relation between meat consumption and the risk of colon cancer. Cancer Research, 54, 718–723.

    Google Scholar 

  • Groopman, J.D., Zhu, J.Q., Donahue. P.R. et al. (1992) Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People’s Republic of China. Cancer Research, 52, 45–52.

    CAS  Google Scholar 

  • Gunderson, E.L. (1995) Dietary intakes of pesticides, selected elements, and other chemicals: FDA Total Diety Study, June 1984-April 1986. Journal of the Association of Official Analytical Chemists, 78, 910–921.

    CAS  Google Scholar 

  • Hall, R.L., Henry, S.H., Scheuplein. R.J. et al. (1989) Comparison of the carcinogenic risks of naturally occurring and adventitious substances in food. In: Taylor, S.L. and Scanlon, R.A. (eds) Food Toxicology: A Perspective on the Relative Risks. Marcel Dekker Inc.. New York, pp. 205–224.

    Google Scholar 

  • Hanham, A.F., Dunn, B.P. and Stich, H.F. (1983) Clastogenic activity of caffeic acid and its relationship to hvdrogen peroxide generated during autooxidation. Mutation Research, 116, 333–339.

    Article  CAS  Google Scholar 

  • Hard, G.C. and Whysner. J. (1994) Risk assessment of d-limonene: an example of male rat– specific renal tumorigens. Critical Reviews in Toxicology, 24. 231–254.

    Article  CAS  Google Scholar 

  • Hart, R., Neumann, D. and Robertson, R. (1995) Dietary Restriction: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies. ILSI Press, Washington, DC.

    Google Scholar 

  • Harvey, M.H., Morris, B.A.. Millan, M. and Marks, V. (1985) Measurement of potato steroidal alkaloids in human serum and saliva by radioimmunoassay. Human Toxicology, 4, 503–512.

    Article  CAS  Google Scholar 

  • Hayward, J.J., Shane, B.S., Tindall, K.R. and Cunningham, M.L. (1995) Differential in vivo mutagenicity of the carcinogen/non-carcinogen pair 2.4- and 2,6-diaminotoluene. Carcinogenesis, 16, 2429–2433.

    Article  CAS  Google Scholar 

  • Heinrich, L. and Baltes, W. (1987) Über die Bestimmung von Phenolen im Kaffeegetränk. Zeitschrift für Lebensmittel-Untersuchung und -Forschung. 185. 362–365.

    Article  CAS  Google Scholar 

  • Henderson, B.E., Ross, R.K. and Pike, M.C. (1991) Towards the primary prevention of cancer. Science, 254, 1131–1138.

    Article  CAS  Google Scholar 

  • Hill, M.J., Giacosa, A. and Caygill, C.P.J, (eds) (1994) Epidemiology of Diet and Cancer. Ellis Horwood. New York.

    Book  Google Scholar 

  • Hultin, H.O. and Proctor, B.E. (1961) Changes in some volatile constituents of the banana during ripening, storage, and processing. Food Technology, 15, 440–444.

    CAS  Google Scholar 

  • Hunter, D.J. and Willett, W.C. (1993) Diet, bodv size, and breast cancer. Epidemiological Reviews, 15, 110–132.

    CAS  Google Scholar 

  • Innes, J.R.M., Ulland, B.M., Valerio, M.G. et al. (1969) Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: a preliminary note. Journal of the National Cancer Institute . 42, 1101–1114.

    CAS  Google Scholar 

  • International Agency for Research on Cancer (1988) Alcohol Drinking. I ARC. Lyon, France.

    Google Scholar 

  • International Agency for Research on Cancer (1991) Coffee, Tea, Mate, Methylxanthines and Methylglyoxal. IARC. Lyon. France.

    Google Scholar 

  • Ishidate, M. Jr, Harnois, M.C. and Sofuni, T. (1988) A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutation Research, 201, 89–96.

    Article  Google Scholar 

  • Kasidas, G.P. and Rose. G.A. (1980) Oxalate content of some common foods: determination by an enzymatic method. Journal of Human Nutrition. 34. 255–266.

    CAS  Google Scholar 

  • Key, T. and Reeves, G. (1994) Organochlorines in the environment and breast cancer. British Medical Journal, 308, 1520–1521.

    CAS  Google Scholar 

  • Kikugawa, K., Kato, T. and Takahashi, S. (1989) Possible presence of 2-amino-3,4-dimethyl- imidazo[4,5-/lquinoline and other heterocyclic amine-like mutagens in roasted coffee beans. Journal of Agriculture and Food Chemistry, 37, 881–886.

    Article  CAS  Google Scholar 

  • Krewski, D., Szyszkowicz, M. and Rosenkranz, H. (1990) Quantitative factors in chemical carcinogenesis: variation in carcinogenic potency. Regulatory Toxicology and Pharmacology, 12, 13–29.

    Article  CAS  Google Scholar 

  • Krewski, D., Gaylor, D.W., Soms, A.P. and Syszkowicz, M. (1993) An overview of the report — Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment. Risk Analysis, 13, 383–398.

    Article  CAS  Google Scholar 

  • Larson, J.L., Wolf, D.C. and Butterworth, B.E. (1994) Induced cytoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3F1 mice: comparison of administration by gavage in corn oil vs. ad libitum in drinking water. Fundamental and Applied Toxicology, 22, 90–102.

    Article  CAS  Google Scholar 

  • Le Marchand, L., Kolonel, L.N., Wilkens, L.R. et al. (1994) Animal fat consumption and prostate cancer: a prospective study in Hawaii. Epidemiology, 5, 275–282.

    Article  Google Scholar 

  • Luckner, M. (1990) Secondary Metabolism in Microorganisms, Plants, and Animals, 3rd edn. Springer-Verlag, New York.

    Google Scholar 

  • Maarse, H., Visscher, C.A., Willemsens, L.C. et al. (eds) (1994) Volatile Compounds in Foods, Qualitative and Quantitative Data. Supplement 5 and Cumulative Index. TNO-CIVO Food Analysis Institute, Zeist, The Netherlands.

    Google Scholar 

  • Macaulay, T., Gallant, C.J., Hooper, S.N. and Chandler, R.F. (1984) Caffeine content of herbal and fast-food beverages. Journal of the Canadian Dietetic Association, 45, 150–156.

    Google Scholar 

  • MacGregor, J.T., Schlegel, R., Wehr, C.M. et al. (1990) Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine. Proceedings of the National Academy of Sciences of the USA, 87, 9962–9965.

    Article  CAS  Google Scholar 

  • Mirsalis, J.C., Provost, G.S., Matthews, C.D. et al. (1993) Induction of hepatic mutations in lacl transgenic mice. Mutagenesis, 8, 265–271.

    Article  CAS  Google Scholar 

  • National Research Council (1979) The 1977 Survey of Industry on the Use of Food Additives. National Academy Press, Washington, DC.

    Google Scholar 

  • National Research Council (1987) Regulating Pesticides in Food: The Delaney Paradox. National Academy Press, Washington, DC.

    Google Scholar 

  • National Research Council (1994) Science and Judgement in Risk Assessment. National Academy Press, Washington, DC.

    Google Scholar 

  • National Toxicology Program (1993) Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91–64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP Technical Report Series No. 422. DHHS, Public Health Service, National Institutes of Health, Research Triangle Park, NC.

    Google Scholar 

  • Neurath, G.B., Diinger, M., Pein, F.G. et al. (1977) Primary and secondary amines in the human environment. Food and Cosmetics Toxicology, 15, 275–282.

    Article  CAS  Google Scholar 

  • Ochiai, M., Masatoshi, W., Hiromi, K. et al. (1996) DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PP in male and female rat colon with relevance to carcinogenesis. Carcinogenesis, 17. 95–98.

    Article  CAS  Google Scholar 

  • Omenn, G.S., Stuebbe, S. and Lave, L.B. (1995) Predictions of rodent carcinogenicity testing results: interpretation in the light of the Lave-Omenn value-of-information model. Molecular Carcinogenicity, 14, 37–45.

    Article  CAS  Google Scholar 

  • Pariza, M.W. and Boutwell, R.K. (1987) Historical perspective: calories and energy expenditure in carcinogenesis. American Journal of Clinical Nutrition, 45(Suppl. 1), 151–156.

    CAS  Google Scholar 

  • Peto, R., Pike, M.C., Bernstein, L. et al. (1984) The TD50: a proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments. Environmental Health Perspectives. 58, 1–8.

    CAS  Google Scholar 

  • Pons, W.A. Jr, (1979) High pressure liquid chromatographic determination of aflatoxins in corn. Journal of the Official Association of Analytical Chemists, 62, 586–594.

    CAS  Google Scholar 

  • Poole, S.K. and Poole, C.F. (1994) Thin-layer chromatographic method for the determination of the principal polar aromatic flavour compounds of the cinnamons of commerce. Analyst, 119, 113–120.

    Article  CAS  Google Scholar 

  • Poulton, J.E. (1983) Cyanogenic compounds in plants and their toxic effects. In: Keeler, R.F. and Tu, A.T. (eds) Handbook of Natural Toxins: Plant and Fungal Toxins, Vol. 1. Marcel Dekker, New York, 117–157.

    Google Scholar 

  • Preston-Martin, S., Pike, M.C., Ross, R.K. and Jones, P.A. (1990) Increased cell division as a cause of human cancer. Cancer Epidemiology Biomarkers and Prevention, 50, 7415–7421.

    CAS  Google Scholar 

  • Preston-Martin, S., Monroe, K., Lee, P.J. et al. (1995) Spinal meningiomas in women in Los Angeles County: investigation of an etiological hypothesis. Cancer Epidemiology Biomarkers and Prevention, 4. 333–339.

    CAS  Google Scholar 

  • Qian, G., Ross, R.K., Yu, M.C. et al. (1994) A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer Epidemiology Biomarkers and Prevention, 3, 3–10.

    CAS  Google Scholar 

  • Rahn, W. and König, W.A. (1978) GC/MS investigations of the constituents in a diethyl ether extract of an acidified roast coffee infusion. Journal of High Resolution Chromatography and Chromatography Communications, 1002, 69–71.

    Article  Google Scholar 

  • Risch, B. and Herrmann, K. (1988) Die Gehalte an Hydroxyzintsäre-Verbindungen und Catechinen in Kern- und Steinobst. Zeitschrift für Lebensmittel-Untersuchung und -Forschung, 186, 225–230.

    Article  CAS  Google Scholar 

  • Roe, F.J.C. (1989) Non-genotoxic carcinogenesis: implications for testing and extrapolation to man. Mutagenesis, 4, 407–411.

    Article  CAS  Google Scholar 

  • Roe, F.J., Lee, P.N., Conybeare, G. et al. (1991) Risks of premature death and cancer predicted by body weight in early adult life. Human Experimental Toxicology, 10, 285–288.

    Article  CAS  Google Scholar 

  • Rosculet, G. and Rickard, M. (1968) Isolation and characterization of flavor components in beer. American Society of Brewing Chemists Proceedings, 203–213.

    Google Scholar 

  • Schmidtlein, H. and Herrmann, K. (1975) Über die Phenolsäuren des Gemüses. II. Hydroxyzimtsäuren und Hydroxybenzoesäuren der Frucht- und Samengemüsearten Zeitschrift für Lebensmittel-Untersuchung und -Forschung, 159, 213–218.

    Article  CAS  Google Scholar 

  • Slattery, M.L., Schumacher, M.C., West, D.W. and Robison, L.M. (1988) Smoking and bladder cancer. The modifying effect of cigarettes on other factors. Cancer, 61, 402–408.

    Article  CAS  Google Scholar 

  • Steinmetz, K.A. and Potter, J.D. (1991) Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes and Control, 2, 325–357.

    Article  CAS  Google Scholar 

  • Stich, H.F., Rosin, M.P., Wu, C.H. and Powrie, W.D. (1981) A comparative genotoxicity study of chlorogenic acid (3-O-caffeoylquinic acid). Mutation Research, 90, 201–212.

    Article  CAS  Google Scholar 

  • Stofberg, J. and Grundschober, F. (1987) Consumption ratio and food predominance of flavoring materials. Second cumulative series. Perfumer and Flavorist, 12, 27–56.

    Google Scholar 

  • Swanson, C.A., Jones, D.Y., Schatzkin, A. et al. (1988) Breast cancer risk assessed by anthropometry in the NHANES I epidemiological follow-up study. Cancer Research, 48, 5363–5367.

    CAS  Google Scholar 

  • Takagi, K., Toyoda, M., Fujiyama, Y. and Saito, Y. (1990) Effect of cooking on the contents of α-chaconine and α-solanine in potatoes. Journal of the Food Hygienic Society of Japan, 31, 67–73.

    CAS  Google Scholar 

  • Technical Assessment Systems (1989) Exposure 1 Software Package. TAS, Washington, DC.

    Google Scholar 

  • Thun, M.J., Calle, E.E., Namboodiri, M.M. et al. (1992) Risk factors for fatal colon cancer in a large prospective study. Journal of the National Cancer Institute, 84, 1491–1500.

    Article  CAS  Google Scholar 

  • Tressl, R., Bahri, D., Köppler, H. and Jensen, A. (1978) Diphenole und Caramelkomponenten in Röstkaffees verschiedener Sorten. II. Zeitschrift für Lebensmittel-Untersuchung und -Forschung, 167, 111–114.

    Article  CAS  Google Scholar 

  • Tucker, J.D., Taylor, R.T., Christensen, M.L. et al. (1989) Cytogenetic response to coffee in Chinese hamster ovary AUXB1 cells and human peripheral lymphocytes. Mutagenesis, 4, 343–348.

    Article  CAS  Google Scholar 

  • United Fresh Fruit and Vegetable Association (1989) Supply Guide: Monthly Availability of Fresh Fruit and Vegetables. UFFVA, Alexandria, VA.

    Google Scholar 

  • US Environmental Protection Agency (1984) Ethylene Dibromide (EDB) Scientific Support and Decision Document for Grain and Grain Milling Fumigation Uses. USEPA, Washington, DC.

    Google Scholar 

  • US Environmental Protection Agency (1989a) Daminozide Special Review. Technical Support Document — Preliminary Determination to Cancel the Food Uses of Daminozide. USEPA, Washington, DC.

    Google Scholar 

  • US Environmental Protection Agency (1989b) Daminozide Special Review. Crop Field Trials. Supplemental Daminozide and UDMH Residue Data for Apples, Cherries, Peanuts, Pears, and Tomatoes. USEPA, Washington, DC.

    Google Scholar 

  • US Environmental Protection Agency (1991a) EBDC/ETU Special Review. DRES Dietary Exposure/Risk Estimates. USEPA, Washington, DC.

    Google Scholar 

  • US Environmental Protection Agency (1991b) Report of the EPA Peer Review Workshop on Alpha2u-globulin: Association with Renal Toxicity and Neoplasia in the Male Rat. USEPA, Washington, DC.

    Google Scholar 

  • US Environmental Protection (1992) Ethylene bisdithiocarbamates (EBDCs); notice of intent to cancel; conclusion of special review. Federal Register, 57, 7484–7530.

    Google Scholar 

  • US Environmental Protection Agency (1994a) Estimating Exposure to Dioxin-Like Compounds (Review Draft). USEPA, Washington, DC.

    Google Scholar 

  • US Environmental Protection Agency (1994b) Health Assessment Document for 2,3,7,8– Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds. USEPA, Washington, DC.

    Google Scholar 

  • US Environmental Protection Agency (1995) Re-evaluating Dioxin: Science Advisory Board’s Review of EPA’s Reassessment of Dioxin and Dioxin-like Compounds. USEPA, Washington, DC.

    Google Scholar 

  • US Environmental Protection Agency. Office of Research and Development (1996) Proposed Guidelines for Carcinogen Risk Assessment. Federal Register, 61, 17960–18011.

    Google Scholar 

  • US Food and Drug Administration (1991a) FDA Pesticide Program: Residues in foods 1990. Journal of the Association of Official Analytical Chemists, 74, 121A-141A.

    Google Scholar 

  • US Food and Drug Administration (1991b) Butylated hydroxyanisole (BHA) intake: Memo from Food and Color Additives Section to L. Lin. USFDA, Washington, DC.

    Google Scholar 

  • US Food and Drug Administration (1992) Exposure to Aflatoxins. USFDA, Washington, DC.

    Google Scholar 

  • US Food and Drug Administration (1993) Food and Drug Administration Pesticide Program: Residue monitoring 1992. Journal of the Association of Official Analytical Chemists, 76, 127A-148A.

    Google Scholar 

  • US Food and Drug Agency (1993) Assessment of carcinogenic upper bound lifetime risk resulting from aflatoxins in consumer peanut and corn products. Report of the Quantitative Risk Assessment Committee. USFDA, Washington, DC.

    Google Scholar 

  • US National Cancer Insitute (1984) NIH Publication No. 84–2039. Everything doesn’t cause cancer: But how can we tell which things cause cancer and which ones don’t? USNCI, Bethesda, MD.

    Google Scholar 

  • Willett, W.C. and Stampfer, M.J. (1990) Dietary fat and cancer — another view. Cancer Causes and Control, 1, 103–109.

    Article  Google Scholar 

  • World Health Organization (1993) Polychlorinated Biphenyls and Terphenyls. Environmental Health Criteria 140. WHO, Geneva.

    Google Scholar 

  • Wu-Williams, A.H., Zeise, L. and Thomas, D. (1992) Risk assessment for aflatoxin B1 a modeling approach. Risk Analysis, 12, 559–567.

    Article  CAS  Google Scholar 

  • Yamagami, T., Handa, H., Juji, T. et al. (1983) Rat pituitary adenoma and hyperplasia induced by caffeine administration. Surgical Neurology, 20, 323–331.

    Article  CAS  Google Scholar 

  • Youngman, L.D., Park, J.Y. and Ames, B.N. (1992) Protein oxidation associated with aging is reduced by dietary restriction of protein or calories. Proceedings of the National Academy of Sciences of the USA, 89, 9112–9116.

    Article  CAS  Google Scholar 

  • Yu, M.C., Tong, M.J., Govindarajan, S. and Henderson, B.E. (1991) Nonviral risk factors for hepatocellular carcinoma in a low-risk population, the non-Asians of Los Angeles County, California. Journal of the National Cancer Institute, 83, 1820–1826.

    Article  CAS  Google Scholar 

  • Zeise, L., Wilson, R. and Crouch, E. (1984) Use of acute toxicity to estimate carcinogenic risk. Risk Analysis, 4, 187–199.

    Article  Google Scholar 

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Gold, L.S., Slone, T.H., Ames, B.N. (1997). Prioritization of possible carcinogenic hazards in food. In: Tennant, D.R. (eds) Food Chemical Risk Analysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1111-9_11

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