Abstract
The major function of the esophagus is to transport food from the mouth to the stomach while preventing retrograde movement of gastric contents. It is in essence a hollow muscular tube that is closed at the proximal portion by the upper esophageal sphincter (UES) and by the lower esophageal sphincter (LES) at the bottom. The pharynx and the proximal esophagus contain striated muscle controlled by the swallowing center in the brain stem through the vagus nerves. The lower two thirds of the esophagus contains smooth muscle with peristalsis controlled primarily by an intrinsic neural network located between the longitudinal and circular muscle layers, and is modulated by central mechanisms in the swallowing center. Proximal esophageal function is complex because the oral cavity and pharynx must necessarily serve multiple functions, not only as a food conduit, but also as a respiratory conduit, thereby requiring precise control and efficient coordination of swallowing and respiration.
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References
Dodds WJ, Stewart ET, Logemann JA: Physiology and radiology of the normal oral and pharyngeal phases of swallowing. AJR Am J Roentgenol 1990, 154:953–963.
Christ J, Gidda JS, Goyal RK: Intramural mechanism of esophageal peristalsis: Roles of cholinergic and noncholinergic nerves. Proc Natl Acad Sci U S A 1984, 81:3595.
Gilbert RJ, Dodds WJ: Effect of selective muscarinic antagonists on peristaltic contractions in opossum smooth muscle. Am J Physiol 1986, 250:G50.
Murray J, Du C, Ledlow A, et al.: Nitric oxide: Mediator of nonadrenergic noncholinergic responses of opossum esophageal muscle. Am J Physiol 1991, 261:G401–G406.
Tottrup A, Svane D, Forman A: Nitric oxide mediating NANC inhibition in opossum lower esophageal sphincter. Am J Physiol 1991, 260:G385–G389.
Kahrilas PJ: The anatomy and physiology of dysphagia. In Dysphagia, Diagnosis, and Treatment. Edited by Gelfand DW, Richter JE. New York: Igaku-Shoin; 1989:11–28.
Kahrilas PJ, Lin S, Logemann JA, et al.: Deglutitive tongue action: Volume accommodation and bolus propulsion. Gastroenterology 1993, 104:152–162.
Kahrilas PJ, Logemann JA, Lin S, et al.: Pharyngeal clearance during swallowing: A combined manometric and videofluoroscopic study. Gastroenterology 1992, 103:128–136.
Kahrilas PJ, Logemann JA, Gibbons P: Food intake by maneuver: An extreme compensation for impaired swallowing. Dysphagia 1992, 7:155–159.
Castell DO: The Esophagus. Edited by Castell DO. Boston: Little, Brown, and Co; 1995: 1–29.
Jacob P, Kahrilas PJ, Logemann JA, et al.: Upper esophageal sphincter opening and modulation during swallowing. Gastroenterology 1989, 97: 1469–1478.
Kahrilas PJ: Volume accommodation during swallowing. Dysphagia 1993, 8:259–265.
Ergun GA, Kahrilas PJ, Lin S, et al.: Shape, volume, and content of the deglutitive pharyngeal chamber imaged by ultrafast CT. Gastroenterology 1993, 105:1396–1403.
Jacob P, Kahrilas PJ, Herzon G, et al.: Determinants of upper esophageal sphincter pressure in dogs. Am J Physiol 1990, 259:G245–G251.
Kahrilas PJ, Lin S, Chen J, et al.: Three dimensional modeling of the oropharynx during swallowing. Radiology 1995, 194:575–579.
Liebermann-Meffert D, Luscher V, Neff V, et al.: Esophagectomy without thoracotomy: Is there a risk of intramediastinal bleeding? A study on blood supply of the esophagus. Ann Surg 1987, 206:184–192.
Kitano S, Terblanche J, Kahn D, et al.: Venous anatomy of the lower oesophagus in portal hypertension: Practical implications. Br J Surg 1986, 73:525–531.
Kahrilas PJ: The effect of peristaltic dysfunction on esophageal volume clearance. Gastroenterology 1988, 94:73–80.
McBride MA, Ergun GA: Role of upper endoscopy in the management of esophageal strictures. Gastrointest Endosc Clin North Am 1994, 4:595–621.
Kahrilas PJ: Functional anatomy and physiology of the esophagus. In The Esophagus. Edited by Castell DO. Boston: Little, Brown, and Co; 1995:1–29.
Sifrim D: Inhibition in the human esophageal body: Its role in normal and disordered motility [thesis]. Katholieke Universiteit Leuven, Leuven, Belgium, 1994.
Goyal RK, Rattan S: Neurohumoral, hormonal, and drug receptors for the lower esophageal sphincter. Gastroenterology 1978, 74:598.
Mittal RK, Rochester DF, McCallum RW: Sphincteric action of the diaphragm during a relaxed lower esophageal sphincter. Am J Physiol 1989, 256:G139–G144.
Boyle JT, Altschuler SM, Nixon TE, et al.: Role of the diaphragm in the genesis of lower esophageal sphincter pressure in the cat. Gastroenterology 1985, 88:723–730.
Mittal RK, Rochester DF, McCallum RW: Electrical and mechanical activity in the human lower esophageal sphincter during diaphragmatic contraction. J Clin Invest 1988, 81:1182–1189.
Mittal RK, Rochester DF, McCallum RW: Sphincteric action of the diaphragm during a relaxed lower esophageal sphincter in humans. Am J Physiol 1989, 256:G139–G144.
Miolan JP, Roman C: Activit des fibres vagales efferentes destines la musculature lessé du cardia du chien. J Physiol Paris 1978, 74:709–723.
Dent J, Dodds WJ, Friedman RH, et al.: Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest 1980, 65:256–257.
Patrikios J, Martin CJ, Dent J: Relationship of transient lower esophageal sphincter relaxation to postprandial gastroesophageal reflux and belching in dogs. Gastroenterology 1986, 90:545.
Martin CJ, Patrikios J, Dent J: Abolition of gas reflux and transient lower esophageal relaxation by vagal blockade in the dog. Gastroenterology 1986, 91:890.
Kahrilas PJ, Gupta RR: Mechanisms of acid reflux associated with cigarette smoking. Gut 1990, 31:4.
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Ergun, G.A., Kahrilas, P.J. (2002). Esophageal Muscular Anatomy and Physiology. In: Orlando, R.C. (eds) Atlas of Esophageal Diseases. Current Medicine Group, London. https://doi.org/10.1007/978-1-4613-1093-8_1
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DOI: https://doi.org/10.1007/978-1-4613-1093-8_1
Publisher Name: Current Medicine Group, London
Print ISBN: 978-1-4757-0809-7
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