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Genetic engineering of immunotoxins

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Immunotoxins

Part of the book series: Cancer Treatment and Research ((CTAR,volume 37))

Abstract

Genetic engineering offers many advantages for the 1) production of immunotoxins (ITs) and 2) design of more effective reagents. In Chapter 9, J.R. Murphy discusses the use of genetic engineering to link genes together resulting in chimeric proteins. This review covers the first applications of genetic engineering technology to improve ITs by studying and altering toxin B chains and broadening the therapeutic index between target and nontarget cells.

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Authors
  1. R. J. Youle
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  2. L. Greenfield
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  3. V. G. Johnson
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Editor information

Editors and Affiliations

  1. Department of Medicine Division of Hematology/Oncology, Duke University Medical Center, Box 3898 DUMC, Durham, North Carolina, 27710, USA

    Arthur E. Frankel

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© 1988 Kluwer Academic Publishers

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Youle, R.J., Greenfield, L., Johnson, V.G. (1988). Genetic engineering of immunotoxins. In: Frankel, A.E. (eds) Immunotoxins. Cancer Treatment and Research, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1083-9_8

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  • DOI: https://doi.org/10.1007/978-1-4613-1083-9_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8419-2

  • Online ISBN: 978-1-4613-1083-9

  • eBook Packages: Springer Book Archive

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