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Structure—activity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A

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Immunotoxins

Part of the book series: Cancer Treatment and Research ((CTAR,volume 37))

Abstract

Although there is no reason in principle why any of several cytocidal bacterial toxins might be used for immuntoxin construction, only two such toxins have been employed extensively to date for this purpose, namely, diphtheria toxin (DT) and Pseudomonas aeruginosa exotoxin A (PE). Diphtheria toxin was an early focus of workers in this area because of the detailed information available at that time on the structure and activity of this particular toxin. Recently PE has been favored over DT by some because of the fact that there has been no vaccine against it. Here the structure and activity of these two toxins is reviewed.

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Authors
  1. R. John Collier
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Editors and Affiliations

  1. Department of Medicine Division of Hematology/Oncology, Duke University Medical Center, Box 3898 DUMC, Durham, North Carolina, 27710, USA

    Arthur E. Frankel

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© 1988 Kluwer Academic Publishers

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Collier, R.J. (1988). Structure—activity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A. In: Frankel, A.E. (eds) Immunotoxins. Cancer Treatment and Research, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1083-9_3

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  • DOI: https://doi.org/10.1007/978-1-4613-1083-9_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8419-2

  • Online ISBN: 978-1-4613-1083-9

  • eBook Packages: Springer Book Archive

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